Patents Assigned to NantCell, Inc.
  • Patent number: 12224064
    Abstract: A method of determining a clinical value for an individual based on a tumor in an image by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to determine a lymphocyte distribution of lymphocytes in the tumor based on the image; apply a classifier to the lymphocyte distribution to classify the tumor, the classifier having been trained to classify tumors into a class selected from at least two classes respectively associated with lymphocyte distributions; and determine the clinical value for the individual based on prognoses of individuals with tumors in the class into which the classifier classified the tumor.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: February 11, 2025
    Assignees: NantCell, Inc., NantOmics, LLC, NantHealth, Inc.
    Inventors: Mustafa I. Jaber, Christopher W. Szeto, Liudmila A. Beziaeva, Stephen Charles Benz
  • Patent number: 12224066
    Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.
    Type: Grant
    Filed: February 2, 2024
    Date of Patent: February 11, 2025
    Assignees: NantOmics, LLC, NantHealth, Inc., NantCell, Inc.
    Inventors: Mustafa I. Jaber, Bing Song, Christopher W. Szeto, Stephen Charles Benz, Shahrooz Rabizadeh, Liudmila A. Beziaeva
  • Patent number: 12168048
    Abstract: Combination therapeutics for the treatment of cancer include the use of immune effector cells, IL-15 based superagonists and one or more immunotherapeutic agents such as Bacillus Calmette-Guerin (BCG).
    Type: Grant
    Filed: May 16, 2024
    Date of Patent: December 17, 2024
    Assignee: NantCell, Inc.
    Inventor: Patrick Soon-Shiong
  • Publication number: 20240398900
    Abstract: An IL-15 super agonist (IL-15N72D: IL-15R?SU/IgGIFc; N-803) increases circulating NK cells, effector memory and effector memory RA cells in post-allogeneic hematopoietic stem cell transplant patients (HCT). Methods of treatment include administration of N-803 to subjects in need of such treatment.
    Type: Application
    Filed: August 19, 2024
    Publication date: December 5, 2024
    Applicant: NantCell, Inc.
    Inventor: Patrick Soon-Shiong
  • Patent number: 12156901
    Abstract: An IL-15 super agonist (IL-15N72D:IL-15R?SU/IgG1Fc; N-803) increases circulating NK cells, effector memory and effector memory RA cells in post-allogeneic hematopoietic stem cell transplant patients (HCT). Methods of treatment include administration of N-803 to subjects in need of such treatment.
    Type: Grant
    Filed: May 31, 2023
    Date of Patent: December 3, 2024
    Assignee: NantCell, Inc.
    Inventor: Patrick Soon-Shiong
  • Patent number: 12112838
    Abstract: Systems and methods for tracking biological samples are presented. Intrinsic and extrinsic biological sample data and/or intrinsic and extrinsic patient data may be used to label a biological sample obtained at a point-of-care facility, which may be sent to a processing facility, wherein the labeled biological sample undergoes analysis and/or processing into a labeled therapeutic. The labeled therapeutic is delivered back to the point-of-care facility, wherein the labeled therapeutic is tested for the presence of the additives prior to administration to a patient. Multi-factor validation is performed, including validating the identity of the patient to a container, validating the identity of the labeled biological sample/therapeutic to the container, and thus, validating the identity of the labeled therapeutic to the patient. The entire life cycle of a biological sample used to generate a personalized therapeutic is validated, and ensures that mix-ups or errors in administration are reduced or eliminated.
    Type: Grant
    Filed: November 29, 2023
    Date of Patent: October 8, 2024
    Assignee: NantCell, Inc.
    Inventors: Kayvan Niazi, Nicholas James Witchey
  • Patent number: 12050802
    Abstract: A geographically distributed erasure coding system includes multiple computer readable, non-transitory storage memories capable of storing a digital dataset including multiple object blocks, where each storage memory is configured to store one or more of the object blocks of the dataset according to an erasure coding policy. The system includes one or more processors configured to implement the erasure coding policy by distributing the multiple object blocks of the dataset to the multiple storage memories according to distribution criteria of the erasure coding policy, and the distribution criteria include at least one status parameter associated with each storage memory. The multiple storage memories are geographically distributed at different locations from one another.
    Type: Grant
    Filed: March 24, 2023
    Date of Patent: July 30, 2024
    Assignee: NantCell, Inc.
    Inventor: Aaron Randolph Bassett
  • Patent number: 12016911
    Abstract: Combination therapeutics for the treatment of cancer include the use of immune effector cells, IL-15 based superagonists and one or more immunotherapeutic agents such as Bacillus Calmette-Guerin (BCG).
    Type: Grant
    Filed: November 15, 2023
    Date of Patent: June 25, 2024
    Assignee: NantCell, Inc.
    Inventor: Patrick Soon-Shiong
  • Patent number: 12006507
    Abstract: An apparatus for electroporating cells with a cargo includes electrodes defining a path for a fluid including the cells and the cargo to flow, a power source coupled across the electrodes, and a control circuit. In some examples, the control circuit is configured to detect a decrease in an induced current due to an increase in a resistance between the electrodes, and control the power source to increase the induced current to maintain an electric field between the electrodes. A future value of the resistance between the electrodes may be predicted based on previous values of the resistance. In other examples, the control circuit is configured to detect parameters of the fluid flowing between the electrodes, and control the power source to generate or stop generating electrical pulses in response to detecting the parameters. Other example apparatuses, and methods of electroporating cells with a cargo is also disclosed.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: June 11, 2024
    Assignee: NantCell, Inc.
    Inventors: Chih-Wei Chang, Jon Thomas Van Lew, Artin Mehrabi
  • Patent number: 11948687
    Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: April 2, 2024
    Assignees: NantCell, Inc., NantHealth, Inc., NantOmics, LLC
    Inventors: Mustafa I. Jaber, Liudmila A. Beziaeva, Bing Song, Christopher W. Szeto, Stephen Charles Benz, Shahrooz Rabizadeh
  • Patent number: 11941813
    Abstract: An example system for performing segmentation of data based on tensor inputs includes memory storing computer-executable instructions defining a learning network, where the learning network includes a plurality of sequential encoder down-sampling blocks. A processor is configured to execute the computer-executable instructions to receive a multi-dimensional input tensor including at least a first dimension, a second dimension and a plurality of channels. The processor is also configured to process the received multi-dimensional input tensor by passing the received multi-dimensional input tensor through the plurality of sequential encoder down-sampling blocks of the learning network, and to generate an output tensor in response to processing the received multi-dimensional input tensor. The output tensor includes at least one segmentation classification.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: March 26, 2024
    Assignee: NantCell, Inc.
    Inventors: Bing Song, Nicholas James Witchey, Albert Wu, Krsto Sbutega, Patrick Soon-Shiong
  • Patent number: 11894109
    Abstract: Systems and methods for tracking biological samples are presented. In some embodiments, intrinsic and extrinsic biological sample data and/or intrinsic and extrinsic patient data are used to label a biological sample obtained at a point-of-care facility. The labeled biological sample may be sent to a processing facility, wherein the labeled biological sample undergoes analysis and/or processing into a labeled therapeutic. The labeled therapeutic is delivered back to the point-of-care facility, wherein the labeled therapeutic is tested for the presence of the additives prior to administration to a patient. Multi-factor validation is performed, including validating the identity of the patient to a container, validating the identity of the labeled biological sample/therapeutic to the container, and thus, validating the identity of the labeled therapeutic to the patient.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: February 6, 2024
    Assignee: NantCell, Inc.
    Inventors: Kayvan Niazi, Nicholas Witchey
  • Publication number: 20240016914
    Abstract: Systems and methods are presented that allow for selection of tumor neoepitopes that are then used to generate recombinant nucleic acids that encode one or more polytopes that are optimized for proper trafficking and processing. In preferred methods, the polytopes are encoded in a plasmid and/or a viral expression system for use as a therapeutic agent.
    Type: Application
    Filed: August 22, 2023
    Publication date: January 18, 2024
    Applicant: NantCell, Inc.
    Inventor: Kayvan Niazi
  • Patent number: 11857612
    Abstract: Combination therapeutics for the treatment of cancer include the use of immune effector cells, IL-15 based superagonists and one or more immunotherapeutic agents such as Bacillus Calmette-Guerin (BCG).
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: January 2, 2024
    Assignee: NantCell, Inc.
    Inventor: Patrick Soon-Shiong
  • Publication number: 20230398186
    Abstract: HIV treatment, and especially treatment of latent infected CD4 cells, can be significantly improved using a kick-and-kill approach that employs an immune stimulation component and/or HDAC inhibition as one treatment component, and that may also include a second component in which a vaccine composition, various NK cells, CAR-T cells, and/or broadly neutralizing antibodies are administered.
    Type: Application
    Filed: August 18, 2023
    Publication date: December 14, 2023
    Applicant: NantCell, Inc.
    Inventors: Kayvan Niazi, Jeffrey Safrit, John H. Lee
  • Patent number: 11786577
    Abstract: HIV treatment, and especially treatment of latent infected CD4 cells, can be significantly improved using a kick-and-kill approach that employs an immune stimulation component and/or HDAC inhibition as one treatment component, and that may also include a second component in which a vaccine composition, various NK cells, CAR-T cells, and/or broadly neutralizing antibodies are administered.
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: October 17, 2023
    Assignee: NantCell, Inc.
    Inventors: Kayvan Niazi, Jeffrey Safrit, John H. Lee
  • Patent number: 11779637
    Abstract: Systems and methods are presented that allow for selection of tumor neoepitopes that are then used to generate recombinant nucleic acids that encode one or more polytopes that are optimized for proper trafficking and processing. In preferred methods, the polytopes are encoded in a plasmid and/or a viral expression system for use as a therapeutic agent.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: October 10, 2023
    Assignee: NantCell, Inc.
    Inventor: Kayvan Niazi
  • Publication number: 20230302121
    Abstract: Compositions and methods are presented for prevention and/or treatment of a coronavirus disease wherein the composition comprises comprises a recombinant entity. The recombinant entity comprises a nucleic acid that encodes a nucleocapsid protein of coronavirus 2 (CoV2); and/or wherein the recombinant entity encodes a spike protein of CoV2.
    Type: Application
    Filed: May 4, 2023
    Publication date: September 28, 2023
    Applicant: NantCell, Inc.
    Inventors: Kayvan Niazi, Thomas H. King
  • Publication number: 20230236172
    Abstract: Compositions and methods are presented that allow for detection and prediction of an immune response in a subject that is selected to receive or that has received a vaccine. In selected embodiments, whole blood is used as starting material to obtain both dendritic cells and T cells, and synthetic or recombinant polypeptide(s) are used that include an antigen of the vaccine. The dendritic cells are then exposed to the synthetic or recombinant polypeptide(s), and thusly exposed dendritic cells are combined with the T cells to generate antigen reactive T cells. For detection or quantification, the antigen reactive T cells are expanded in vitro prior to ELISPOT or FACS analysis. Advantageously, such systems and methods are especially suitable for ascertaining an immune response against cancer antigens following vaccination with an anti-cancer vaccine.
    Type: Application
    Filed: March 4, 2021
    Publication date: July 27, 2023
    Applicant: NantCell, Inc.
    Inventor: Peter Sieling
  • Patent number: 11701408
    Abstract: An EL-15 super agonist (IL-15N72D:IL-15R?SU/IgG1Fc; N-803) increases circulating NK cells, effector memory and effector memory RA cells in post-allogeneic hematopoietic stem cell transplant patients (HCT). Methods of treatment include administration of N-803 to subjects in need of such treatment.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: July 18, 2023
    Assignee: NantCell, Inc.
    Inventor: Patrick Soon-Shiong