Patents Assigned to Nantomics
-
Publication number: 20240170149Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.Type: ApplicationFiled: February 2, 2024Publication date: May 23, 2024Applicant: NantOmics, LLCInventors: Mustafa I. JABER, Bing SONG, Christopher W. SZETO, Stephen Charles BENZ, Shahrooz RABIZADEH, Liudmila A. BEZIAEVA
-
Patent number: 11981893Abstract: RNA from a biological fluid is stabilized during isolation and/or storage using DNA. In especially preferred aspects, the RNA is cfRNA and/or ctRNA, and the biological fluid is blood.Type: GrantFiled: October 4, 2021Date of Patent: May 14, 2024Assignee: Nantomics LLCInventors: Patrick Soon-Shiong, Shahrooz Rabizadeh, Kathleen Danenberg
-
Publication number: 20240153650Abstract: Contemplated systems and methods use identification and classification of somatic single nucleotide variants found in a primary tumor and metastases to determine phylogeny of the metastases.Type: ApplicationFiled: November 28, 2023Publication date: May 9, 2024Applicant: Nantomics LLCInventor: John Zachary Sanborn
-
Patent number: 11954856Abstract: Techniques are provided for determining a cell count within a whole slide pathology image. The image is segmented using a global threshold value to define a tissue area. A plurality of patches comprising the tissue area are selected. Stain intensity vectors are determined within the plurality of patches to generate a stain intensity image. The stain intensity image is iteratively segmented to generate a cell mask using a local threshold value that is and gradually reduced after each iteration. A chamfer distance transform is applied to the cell mask to generate a distance map. Cell seeds are determined on the distance map. Cell segments are determined using a watershed transformation, and a whole cell count is calculated for the plurality of patches based on the cell segments. A client device may be configured for real-time cell counting based on the whole cell count.Type: GrantFiled: August 4, 2022Date of Patent: April 9, 2024Assignee: NantOmics, LLCInventors: Bing Song, Liudmila A Beziaeva, Shahrooz Rabizadeh
-
Patent number: 11954596Abstract: Techniques are provided for determining classifications based on WSIs. A varied-size feature map is generated for each training WSI by generating a grid of patches for the training WSI, segmenting the training WSI into tissue and non-tissue areas, and converting patches comprising the tissue areas into tensors. Bounding boxes are generated based on the patches comprising tissue areas and segmented into feature map patches. A fixed-size feature map is generated based on a subset of the feature map patches. A classifier model is trained to process fixed-size feature maps corresponding to the training WSIs such that, for each fixed-size feature map, the classifier model is operable to assign a WSI-level tissue or cell morphology classification or regression based on the tensors. A classification engine is configured to use the trained classifier model to determine a WSI-level tissue or cell morphology classification or regression for a test WSI.Type: GrantFiled: March 10, 2020Date of Patent: April 9, 2024Assignees: NantOmics, LLC, NantHealth, Inc.Inventors: Bing Song, Mustafa Jaber, Liudmila Beziaeva, Shahrooz Rabizadeh
-
Patent number: 11948687Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.Type: GrantFiled: July 21, 2021Date of Patent: April 2, 2024Assignees: NantCell, Inc., NantHealth, Inc., NantOmics, LLCInventors: Mustafa I. Jaber, Liudmila A. Beziaeva, Bing Song, Christopher W. Szeto, Stephen Charles Benz, Shahrooz Rabizadeh
-
Patent number: 11908588Abstract: Contemplated systems and methods use identification and classification of somatic single nucleotide variants found in a primary tumor and metastases to determine phylogeny of the metastases.Type: GrantFiled: August 25, 2016Date of Patent: February 20, 2024Assignee: NantOmics LLCInventor: John Zachary Sanborn
-
Publication number: 20240021314Abstract: Methods for analyzing omics data and using the omics data to determine prognosis of a cancer, to predict an outcome of a treatment, and/or to determine an effectiveness of a treatment are presented. In preferred methods, blood from a patient having a cancer or suspected to have a cancer is obtained and blood omics data for a plurality of cancer-related, inflammation-related, or DNA repair-related genes are obtained. A cancer score can be calculated based on the omics data, which then can be used to provide a cancer prognosis, a therapeutic recommendation, an effectiveness of a treatment.Type: ApplicationFiled: September 26, 2023Publication date: January 18, 2024Applicant: Nantomics LLCInventors: Shahrooz Rabizadeh, Patrick Soon-Shiong
-
Patent number: 11875877Abstract: Systems and methods for prediction of the treatment outcome for immune therapy are presented in which omics data of a patient tumor sample are used. Most typically, the omics data are processed to identify mutational signatures (especially APOBEC/POLE signatures), immune checkpoint expression, and MSI status as leading indicators to predict the treatment outcome for immune therapy. Such prediction advantageously integrates various parameters that would otherwise, when individually considered, skew prediction outcome.Type: GrantFiled: August 25, 2017Date of Patent: January 16, 2024Assignee: NantOmics, LLCInventors: Andrew Nguyen, John Zachary Sanborn, Shahrooz Rabizadeh
-
Publication number: 20230420137Abstract: Methods for analyzing omics data and using the omics data to determine prognosis of a cancer, to predict an outcome of a treatment, and/or to determine an effectiveness of a treatment are presented. In preferred methods, blood from a patient having a cancer or suspected to have a cancer is obtained and blood omics data for a plurality of cancer-related, inflammation-related, or DNA repair-related genes are obtained. A cancer score can be calculated based on the omics data, which then can be used to provide a cancer prognosis, a therapeutic recommendation, an effectiveness of a treatment.Type: ApplicationFiled: September 12, 2023Publication date: December 28, 2023Applicant: Nantomics, LLCInventors: Shahrooz Rabizadeh, Patrick Soon-Shiong
-
Publication number: 20230383366Abstract: Circulating free RNA (cfRNA) is used for monitoring status and/or treatment response for neural tumors, and especially glioma, glioblastoma, and neuroblastoma. Particularly preferred cfRNAs include those that encode a marker that is specific to a neural tumor, but also markers that are specific to DNA repair status and/or immune status.Type: ApplicationFiled: August 9, 2023Publication date: November 30, 2023Applicant: Nantomics LLCInventor: Shahrooz Rabizadeh
-
Patent number: 11821043Abstract: Circulating free RNA (cfRNA) is used for monitoring status and/or treatment response for neural tumors, and especially glioma, glioblastoma, and neuroblastoma. Particularly preferred cfRNAs include those that encode a marker that is specific to a neural tumor, but also markers that are specific to DNA repair status and/or immune status.Type: GrantFiled: August 17, 2018Date of Patent: November 21, 2023Assignee: NantOmics LLCInventor: Shahrooz Rabizadeh
-
Patent number: 11810672Abstract: Methods for analyzing omics data and using the omics data to determine prognosis of a cancer, to predict an outcome of a treatment, and/or to determine an effectiveness of a treatment are presented. In preferred methods, blood from a patient having a cancer or suspected to have a cancer is obtained and blood omics data for a plurality of cancer-related, inflammation-related, or DNA repair-related genes are obtained. A cancer score can be calculated based on the omics data, which then can be used to provide a cancer prognosis, a therapeutic recommendation, an effectiveness of a treatment.Type: GrantFiled: October 11, 2018Date of Patent: November 7, 2023Assignee: NantOmics, LLCInventors: Shahrooz Rabizadeh, Patrick Soon-Shiong
-
Patent number: 11785004Abstract: Various devices, systems, structures and methods are disclosed related to securely authorizing a transaction by synchronizing digital genomic data with associated synthetic genomic variants. An embodiment of the present invention utilizes digital genomic data associated with an entity, such as a person, who may utilize a genome-based security device to complete a transaction. In one embodiment, a person may use a genome-based security device to communicate with an external device over a wireless or other communication interface, synchronize digital genomic data and an associated synthetic variant received from the external device with digital genomic data and associated synthetic variant stored on the genome-based security device.Type: GrantFiled: March 29, 2022Date of Patent: October 10, 2023Assignees: NantHealth, Inc., NantOmics, LLC, Nant Holdings IP, LLCInventors: Patrick Soon-Shiong, Stephen Benz, Rahul Chaturvedi
-
Patent number: 11785002Abstract: Various devices, systems, structures and methods are disclosed related to securely authorizing a transaction by synchronizing digital genomic data with associated synthetic genomic variants. An embodiment of the present invention utilizes digital genomic data associated with an entity, such as a person, who may utilize a genome-based security device to complete a transaction. In one embodiment, a person may use a genome-based security device to communicate with an external device over a wireless or other communication interface, synchronize digital genomic data and an associated synthetic variant received from the external device with digital genomic data and associated synthetic variant stored on the genome-based security device.Type: GrantFiled: July 12, 2018Date of Patent: October 10, 2023Assignees: NantHealth, Inc., NantOmics, LLC, Nant Holdings IP, LLCInventors: Patrick Soon-Shiong, Stephen Benz, Rahul Chaturvedi
-
Publication number: 20230307090Abstract: Systems and methods are presented that allow for predicting treatment response of a tumor to a checkpoint inhibitor. In one exemplary aspect, the treatment response is directly associated with a relatively high number of patient- and tumor-specific immunologically visible neoepitopes. Specific mutational patterns in the nucleic acid encoding the neoepitope may be further indicative of treatment response.Type: ApplicationFiled: February 2, 2023Publication date: September 28, 2023Applicant: Nantomics LLCInventors: Andrew Nguyen, Kayvan Niazi, Patrick Soon-Shiong, Stephen Charles Benz, Shahrooz Rabizadeh
-
Patent number: 11756651Abstract: An immune gene expression signature is associated with favorable clinical features in Treg-enriched tumor samples and can be used to predict immunogenicity of a tumor, overall survival, and/or chemosensitivity.Type: GrantFiled: December 21, 2018Date of Patent: September 12, 2023Assignees: Nantomics LLC, NantBio, Inc., Nant Holdings IP, LLCInventors: Kevin B. Givechian, Kamil A. Wnuk, Chad Garner, Stephen Charles Benz, Hermes J. Garban, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
-
Publication number: 20230274796Abstract: Techniques are provided for predicting MHC-peptide binding affinity. A plurality of training peptide sequences is obtained, and a neural network model is trained to predict MHC-peptide binding affinity using the training peptide sequences. An encoder of the neural network model comprising an RNN is configured to process an input training peptide sequence to generate a fixed-dimension encoding output by applying a final hidden state of the RNN at intermediate state outputs of the RNN to generate attention weighted outputs, and linearly combining the attention weighted outputs. A fully connected layer following the encoder is configured to process the fixed-dimension encoding output to generate an MHC-peptide binding affinity prediction output. A computing device is configured to use the trained neural network to predict MHC-peptide binding affinity for a test peptide sequence.Type: ApplicationFiled: January 12, 2023Publication date: August 31, 2023Applicant: NantOmics, LLCInventors: Jeremi Sudol, Kamil Wnuk
-
Publication number: 20230260628Abstract: A method at a computing device for classifying elements within an input, the method including breaking the input into a plurality of patches; for each patch: creating a vector output; applying a characterization map to select a classification bin from a plurality of classification bins; and utilizing the selected classification bin to classify the vector output to create a classified output; and compiling the classified output from each patch.Type: ApplicationFiled: April 26, 2023Publication date: August 17, 2023Applicants: NantOmics, LLC, NantHealth, Inc.Inventors: Mustafa Jaber, Liudmila A Beziaeva, Christopher W Szeto, Bing Song
-
Publication number: 20230262055Abstract: Various devices, systems, structures and methods are disclosed related to securely authorizing a transaction by synchronizing digital genomic data with associated synthetic genomic variants. An embodiment of the present invention utilizes digital genomic data associated with an entity, such as a person, who may utilize a genome-based security device to complete a transaction. In one embodiment, a person may use a genome-based security device to communicate with an external device over a wireless or other communication interface, synchronize digital genomic data and an associated synthetic variant received from the external device with digital genomic data and associated synthetic variant stored on the genome-based security device.Type: ApplicationFiled: December 19, 2022Publication date: August 17, 2023Applicants: NantHealth, Inc., NantOmics, LLC, Nant Holdings IP, LLCInventors: Patrick Soon-Shiong, Stephen Benz, Rahul Chaturvedi