Patents Assigned to Nantong University
  • Publication number: 20250144272
    Abstract: A cell matrix nerve graft for repairing peripheral nerve injury and a preparation method thereof are provided. The cell matrix nerve graft comprises acellular matrix and a scaffold, wherein the acellular matrix is obtained by decellularization after secretion and formation of stem cells, and the acellular matrix is wrapped around the scaffold. The defects of autologous nerve transplantation repair can be overcome and the immunogenicity of allogeneic cell transplantation repair is avoided. The cell matrix nerve graft beneficial to nerve cell proliferation and migration is provided, a microenvironment beneficial to axon growth is established, the purposes of nerve regeneration and function repair are achieved, and a feasible solution is provided for clinical treatment of nerve defects.
    Type: Application
    Filed: July 25, 2023
    Publication date: May 8, 2025
    Applicant: NANTONG UNIVERSITY
    Inventors: Meiyuan LI, Xiaosong GU, Lingchi XU, Leilei GONG, Hualin SUN, Shanshan WANG, Hongkui WANG, Tianmei QIAN, Lai XU
  • Publication number: 20250127817
    Abstract: An application of Bone Marrow Mesenchyml Stem Cell Exosomes (BMSC-Exos) in treating Parkinson's disease (PD) is provided, wherein the BMSC-Exos are generated by stimulating BMSCs with a culture solution and extracted from the culture solution after passage; and the culture solution of the BMSCs is an ?-MEM culture solution containing FBS and PS. The BMSC-Exos can greatly improve a motor function of a model mouse with PD, protect dopaminergic neurons of the model mouse with PD, improve an olfactory function of the model mouse with PD, and also inhibit the activation of olfactory astrocytes of the model mouse with PD.
    Type: Application
    Filed: October 19, 2022
    Publication date: April 24, 2025
    Applicant: NANTONG UNIVERSITY
    Inventors: Xiaosong GU, Cheng SUN, Fei DING, Leilei GONG, Meng CONG, Xiaomin WANG, Hualin SUN, Yu ZHANG, Lili ZHAO, Tianmei QIAN
  • Patent number: 12266853
    Abstract: Disclosed is an integrated structure of a differential dielectric resonator antenna and a separately controllable dual-band filter. The integrated structure includes a dielectric substrate, a rectangular dielectric resonator and a feed structure. Two functions, i.e., an antenna function and a filter function, which do not interfere with each other, are realized at the same time. Differential excitation is performed on a main mode of the rectangular dielectric resonator, so as to design a differential dielectric resonator antenna. A separately controllable first passband of the filter is integrated and realized on a virtual ground of the differential dielectric resonator antenna, and then a separately controllable second passband of the filter is realized by using a reflection ground. The antenna and the filter share the same module, but maintain good isolation, such that the number and volume of microwave devices in a radio frequency system can be reduced.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: April 1, 2025
    Assignee: NANTONG UNIVERSITY
    Inventors: Hui Tang, Cheng Shao, Jie Ge, Qingyuan Lu, Jianxin Chen
  • Patent number: 12204070
    Abstract: A method for analyzing signal irregularity of radiation in a lightning leader is provided, which relates to a field of lightning signal processing and includes: S1: acquiring electric field signals; S2: dividing the electric field signals into multiple segments according to time, and calculating an average sample entropy value of each segment of the electric field signals; S3: dividing the multiple segments of electric field signals into three regions according to the time, quantifying irregularity of radiation of the three regions in the leader according to sample entropies and performing classification based on numerical variation characteristics of the irregularity; S4: comparing the classified data with lightning positioning data to form an analysis database; and S5: acquiring real-time electric field signals, calculating average sample entropy values of the electric field signals, and predicting development characteristics of irregular radiation in the lightning leader.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: January 21, 2025
    Assignees: Nantong University, Institute of Atmospheric Physics, Chinese Academy of Sciences
    Inventors: Zilong Ma, Rubin Jiang, Xiushu Qie, Hongyan Xing, Hongbo Zhang
  • Publication number: 20250003006
    Abstract: The present disclosure provides use of a transmembrane emp24 domain 8 (TMED8) gene in preparation of a drug and a diagnostic kit for pancreatic cancer, and belongs to the technical field of precision tumor medicine. In the present disclosure, it is found that up-regulating an expression level of the TMED8 gene has significantly inhibited migration and proliferation of pancreatic cancer cells, and then promoted apoptosis of the pancreatic cancer cells; the TMED8 gene is further found to be related to a mitogen-activated protein kinase (MAPK) signaling pathway. Therefore, the TMED8 gene may be used as an effective target for gene diagnosis and treatment of the pancreatic cancer.
    Type: Application
    Filed: March 12, 2024
    Publication date: January 2, 2025
    Applicant: AFFILIATED HOSPITAL OF NANTONG UNIVERSITY
    Inventors: Mingbing XIAO, Tong WU, Xingjuan FAN, Jiahai SHI, Wenjie ZHENG, Wenkai NI, Chengqi GUAN, Ziwei CHEN
  • Publication number: 20240374101
    Abstract: A stair cleaning robot based on retractable rotational arms, including a cleaning robot body, wherein the cleaning robot body includes a machine body, a control system disposed at the top of the machine body, and a cleaning mechanism disposed at the bottom of the machine body; a first retractable rotational arm mechanism is disposed on the left side of the machine body, a second retractable rotational arm mechanism is disposed on the right side of the machine body, and the first retractable rotational arm mechanism and the second retractable rotational arm mechanism are disposed in a bilateral symmetry manner; the control system includes a control plate, a battery and a radar which are disposed on a control seat; a first reset sensor is disposed near the radar, and a second reset sensor is disposed near the control plate.
    Type: Application
    Filed: May 18, 2023
    Publication date: November 14, 2024
    Applicant: NANTONG UNIVERSITY
    Inventors: Lei ZHANG, Jiangen SHAO, Lei SU, Haitao LIU, Yu LIU, Xingtian YAO, Lijuan DAI
  • Patent number: 12131474
    Abstract: The present disclosure is a three-way U-Net method for accurately segmenting an uncertain boundary of a retinal blood vessel, includes: describing an uncertainty of a blood vessel boundary label, constructing an upper bound and a lower bound of the uncertain boundary based on the dilation operator and the erosion operator respectively to obtain a maximum value and a minimum value for the blood vessel boundary, and mapping the boundary with uncertain information into one range; combining an uncertainty representation of the boundary with a loss function, and designing a three-way loss function; training network parameters by adopting a stochastic gradient descent algorithm and utilizing a total loss of the three-way loss function; and designing and implements an auxiliary diagnosis application system for intelligently segmenting the retinal blood vessel with functions of the fundus data acquisition, the intelligent accurate segmentation and the auxiliary diagnosis for the retinal blood vessel.
    Type: Grant
    Filed: May 24, 2023
    Date of Patent: October 29, 2024
    Assignee: NANTONG UNIVERSITY
    Inventors: Weiping Ding, Ying Sun, Tao Hou, Xinjie Shen, Hengrong Ju, Jiashuang Huang, Haipeng Wang, Tingzhen Qin, Yu Geng, Ming Li, Haowen Xue, Zhongyi Wang
  • Patent number: 12115204
    Abstract: Disclosed are a compound preparation for neuranagenesis, and a preparation method therefor and the use thereof. The compound preparation for neuranagenesis comprises the raw medicinal materials in parts by weight: 10-20 parts of raw Astragali radix, 10-20 parts of Rehmaimiae Radix praeparata, 10-20 parts of Actyranthes bidentata, 6-15 parts of Jujubae fructus, 6-15 parts of Lycii fructus, 6-15 parts of parched Ziziphi spinosae semen, 6-12 parts of Angelicae smensis radix, 3-9 parts of Carthami flos, 6-15 parts of Poria, 6-15 parts of parched Atractylodis macrocephalae rhizoma and 10-20 parts of Zaocys. The compound preparation can be used for preparing drugs to treat nerve damage diseases, and can be prepared into oral liquids, granules, dissolved granules and tablets.
    Type: Grant
    Filed: January 5, 2021
    Date of Patent: October 15, 2024
    Assignee: NANTONG UNIVERSITY
    Inventors: Xiaosong Gu, Chunkang Tang, Fei Ding, Xiaoming Yang, Qiong Cheng, Hualin Sun, Lai Xu
  • Patent number: 12104882
    Abstract: Skin-core structure fibers with both infrared and radar stealth, a preparation method therefor, and the use thereof are provided. The fibers are as follows: a core material of the skin-core structure fibers comprises the following raw materials in parts by weight: 10 parts of paraffin; 0.7-1.5 parts of an electromagnetic wave absorbent; and 1 part of a high-molecular polymer, wherein the electromagnetic wave absorbent is one or more of ferroferric oxide-intercalated graphene oxide, nano ferroferric oxide and carbon black, and wherein the skin-core structure fiber is obtained by spinning the core material with a skin-layer material.
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: October 1, 2024
    Assignee: NANTONG UNIVERSITY
    Inventors: Wei Ye, Xing Zhang, Qilong Sun, Xiaoyun Long, Qiang Gao, Tao Ji
  • Patent number: 12091552
    Abstract: Disclosed are reactive dyes and preparation methods thereof. The reactive dye may be prepared using heterocyclic primary amine as a diazo component, 4,4?-diamino-2,2?-stilbenedisulfonic acid, s-triazine, or ethylenediamine as a bridging group, and a dimonochlortriazine group as an active group. The color-changing compound is covalently bonded into the fiber chemical structure by nucleophilic substitution reaction between monochlorotriazine and the hydroxyl group in a textile structure, and the size of the conjugated system and the range of electron delocalization of the dye are changed by a reversible isomerization reaction of the hydroxyl group adjacent to the diazo group and the diazo group under different pH regulations. Moreover, the dye has a double color changing structure, which improves the capability of the dye combined with —H/—OH. The pH value range that can cause color changes in the dye is effectively expanded to include weak alkali, weak acid or even neutral conditions.
    Type: Grant
    Filed: August 7, 2023
    Date of Patent: September 17, 2024
    Assignee: NANTONG UNIVERSITY
    Inventors: Min Li, Wujun Ma, Jialiang Zhou, Wenlin Qu, Ting Ding, Lifen Mao, Shiyu Li
  • Publication number: 20240289952
    Abstract: The present disclosure is a three-way U-Net method for accurately segmenting an uncertain boundary of a retinal blood vessel, includes: describing an uncertainty of a blood vessel boundary label, constructing an upper bound and a lower bound of the uncertain boundary based on the dilation operator and the erosion operator respectively to obtain a maximum value and a minimum value for the blood vessel boundary, and mapping the boundary with uncertain information into one range; combining an uncertainty representation of the boundary with a loss function, and designing a three-way loss function; training network parameters by adopting a stochastic gradient descent algorithm and utilizing a total loss of the three-way loss function; and designing and implements an auxiliary diagnosis application system for intelligently segmenting the retinal blood vessel with functions of the fundus data acquisition, the intelligent accurate segmentation and the auxiliary diagnosis for the retinal blood vessel.
    Type: Application
    Filed: May 24, 2023
    Publication date: August 29, 2024
    Applicant: NANTONG UNIVERSITY
    Inventors: Weiping DING, Ying SUN, Tao HOU, Xinjie SHEN, Hengrong JU, Jiashuang HUANG, Haipeng WANG, Tingzhen QIN, Yu GENG, Ming LI, Haowen XUE, Zhongyi WANG
  • Publication number: 20240210144
    Abstract: Provided is a bullet-proof and stab-proof material. The bullet-proof and stab-proof material includes an impact-resistant layer and a cutting-resistant, bullet-proof and energy-absorbing layer, where the impact-resistant layer is one or more Kevlar fiber-based unidirectional (UD) sheets; and the cutting-resistant, bullet-proof and energy-absorbing layer is formed by stacking a plurality of the Kevlar fiber-based UD sheets and/or a plurality of ultra-high-molecular-weight polyethylene (UHMWPE) fiber-based UD sheets, or by stacking a plurality of Kevlar/UHMWPE hybrid fiber-based UD sheets.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 27, 2024
    Applicant: NANTONG UNIVERSITY
    Inventors: Hongxia CHEN, Haijian CAO, Xuefeng YAN, Yan MA, Xiaomei HUANG
  • Publication number: 20240212844
    Abstract: A chronic pain Internet plus management platform is provided to perform file management for patients with chronic diseases by taking multi-dimension and multi-level information about patients as a starting point for chronic disease diagnosis, taking respective hospitals and home personal mobile devices as an information collecting media and integrating with an Internet chronic disease cloud database, thereby realizing AI-assisted screening, and intelligent analysis and prediction of health risks. Anew mode for chronic pain management is established by the new generation of information technology, such as mobile Internet, cloud computing and big data; meanwhile, self-management of the patient is assisted by the mode for chronic pain management to improve prognosis of chronic pain.
    Type: Application
    Filed: June 24, 2022
    Publication date: June 27, 2024
    Applicant: Affiliated Hospital of Nantong University
    Inventors: Xiang ZHU, Chenlu JIANG, Jiacheng ZHAO, Yibin QIN, Xiaqing MA, Cuie LU, Qiang GU, Weiwei ZHOU, Can ZHOU, Jiapei CAI, Zhusheng CHEN, Ming LI
  • Patent number: 11998583
    Abstract: A Fructus Forsythiae and Radix Astragali compound preparation, and a preparation method therefor and a use thereof is provided. Traditional Chinese medicine formulation components consist of the following raw materials or raw material extracts in parts by mass: 9-11 parts of Flos Lonicerae, 9-11 parts of Fructus Forsythiae, 9-11 parts of Radix Scutellariae, 9-11 parts of Herba Artemisiae Annuae, 9-11 parts of Radix Astragali, 9-11 parts of stir-fried Rhizoma Atractylodis Macrocephalae, 9-11 parts of Herba Pogostemonis, 5-7 parts of Radix Saposhnikoviae, 9-11 parts of Radix Ophiopogonis, and 5-7 parts of Radix Glycyrrhizae. The components can be made into an oral liquid, a granule, a dissolved medicine, or a tablet. Further disclosed is a use of the Fructus Forsythiae and Radix Astragali compound preparation in preparation of medicines for preventing and/or treating a viral influenza disease.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: June 4, 2024
    Assignee: NANTONG UNIVERSITY
    Inventors: Xiaosong Gu, Chunkang Tang, Leilei Gong, Yu Zhang, Qiong Cheng, Xiaoming Yang, Xiaomin Wang
  • Publication number: 20240175661
    Abstract: Skin-core structure fibers with both infrared and radar stealth, a preparation method therefor, and the use thereof are provided. The fibers are as follows: a core material of the skin-core structure fibers comprises the following raw materials in parts by weight: 10 parts of paraffin; 0.7-1.5 parts of an electromagnetic wave absorbent; and 1 part of a high-molecular polymer, wherein the electromagnetic wave absorbent is one or more of ferroferric oxide-intercalated graphene oxide, nano ferroferric oxide and carbon black, and wherein the skin-core structure fiber is obtained by spinning the core material with a skin-layer material.
    Type: Application
    Filed: May 10, 2022
    Publication date: May 30, 2024
    Applicant: NANTONG UNIVERSITY
    Inventors: Wei YE, Xing ZHANG, Qilong SUN, Xiaoyun LONG, Qiang GAO, Tao JI
  • Patent number: 11987886
    Abstract: The present application provides a preparation method for a core-shell structured tungsten/gadolinium oxide functional fiber for X and ? ray protection, comprising: first preparing a core-shell structured tungsten/gadolinium oxide powder; preparing a W@Gd2O3/PP blended melt from the powder; and preparing a W@Gd2O3/PP composite fiber from the blended melt. The core-shell structured tungsten/gadolinium oxide functional fiber prepared by the method can play a role in synergistic protection in the aspect of radiation protection, eliminate a weak protection area, and effectively absorb secondary radiation generated by radiation. Secondly, the prepared functional fiber has the characteristics of no lead and light weight, and has good application prospects in the aspect of X and ? ray radiation protection.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: May 21, 2024
    Assignee: NANTONG UNIVERSITY
    Inventors: Lirong Yao, Yong Xia, Tao Yang, Tong Sun, Gangwei Pan, Sijun Xu, Tao Ji, Qiang Gao
  • Publication number: 20240093374
    Abstract: The present application provides a preparation method for a core-shell structured tungsten/gadolinium oxide functional fiber for X and ? ray protection, comprising: first preparing a core-shell structured tungsten/gadolinium oxide powder; preparing a W@Gd2O3/PP blended melt from the powder; and preparing a W@Gd2O3/PP composite fiber from the blended melt. The core-shell structured tungsten/gadolinium oxide functional fiber prepared by the method can play a role in synergistic protection in the aspect of radiation protection, eliminate a weak protection area, and effectively absorb secondary radiation generated by radiation. Secondly, the prepared functional fiber has the characteristics of no lead and light weight, and has good application prospects in the aspect of X and ? ray radiation protection.
    Type: Application
    Filed: August 16, 2021
    Publication date: March 21, 2024
    Applicant: NANTONG UNIVERSITY
    Inventors: Lirong YAO, Yong XIA, Tao YANG, Tong SUN, Gangwei PAN, Sijun XU, Tao JI, Qiang GAO
  • Publication number: 20240084144
    Abstract: Disclosed are reactive dyes and preparation methods thereof. The reactive dye may be prepared using heterocyclic primary amine as a diazo component, 4,4?-diamino-2,2?-stilbenedisulfonic acid, s-triazine, or ethylenediamine as a bridging group, and a dimonochlortriazine group as an active group. The color-changing compound is covalently bonded into the fiber chemical structure by nucleophilic substitution reaction between monochlorotriazine and the hydroxyl group in a textile structure, and the size of the conjugated system and the range of electron delocalization of the dye are changed by a reversible isomerization reaction of the hydroxyl group adjacent to the diazo group and the diazo group under different pH regulations. Moreover, the dye has a double color changing structure, which improves the capability of the dye combined with —H/—OH. The pH value range that can cause color changes in the dye is effectively expanded to include weak alkali, weak acid or even neutral conditions.
    Type: Application
    Filed: August 7, 2023
    Publication date: March 14, 2024
    Applicant: NANTONG UNIVERSITY
    Inventors: Min LI, Wujun MA, Jialiang ZHOU, Wenlin QU, Ting DING, Lifen MAO, Shiyu LI
  • Patent number: 11927563
    Abstract: A smart acoustic information recognition-based welded weld impact quality determination method and system, comprising: controlling a tip of an ultrasonic impact gun (1) to perform impact treatment on a welded weld with different treatment pressures, treatment speeds, treatment angles and impact frequencies, obtaining acoustic signals during the impact treatment, calculating feature values of the acoustic signals, and constructing an acoustic signal sample set including various stress conditions; marking the acoustic signal sample set according to impact treatment quality assessment results for the welded weld; establishing a multi-weight neural network model, and using the marked acoustic signal sample set to train the multi-weight neural network model; obtaining feature values of welded weld impact treatment acoustic signals to be determined, inputting the feature values into the trained multi-weight neural network model, and outputting determination results for welded weld impact treatment quality to be det
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: March 12, 2024
    Assignee: NANTONG UNIVERSITY
    Inventors: Liang Hua, Ling Jiang, Juping Gu, Cheng Lu, Kun Zhang, Kecai Cao, Liangliang Shang, Qi Zhang, Shenfeng Wang, Yuxuan Ge, Zixi Ling, Jiawei Miao
  • Patent number: 11882797
    Abstract: An automatic detection and recovery device for residual agricultural mulch film, and a method of using the device, comprising a quadcopter, a wheeled robot (9), and a host computer (8); the quadcopter is provided with a controller (1), a near infrared water content analyzer, and a WiFi module that are used to measure water content in soil and communicate with the host computer; the wheeled robot (9) comprises a water sprinkling device (2), a soil grabbing device (3), a sifting device (4), a delivery device (5), a recognition device (6), and a sorting device (7).
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: January 30, 2024
    Assignee: NANTONG UNIVERSITY
    Inventors: Liang Hua, Zeguang Zhang, Jiahan You, Yisheng Huang, Ping Lu