Abstract: Harmful effects of histamine are counteracted by the administration of an antihistaminic substance comprising a water extract of a plant tissue of Stevia. Standing of the extract naturally cause fermentation to form one or more organic acids, such as lactic acid and acetic acid, thereby enhancing the antihistaminic action. The addition of at least one organic acid to the extract immediately after extraction can also enhance the antihistaminic action.

Abstract: An antihistaminic substance comprising an extract from a plant tissue of Stevia, which is primarily contained in its stems and leaves, and in a cold water, hot water or lower alcohol extract thereof. Standing of the extract naturally causes fermentation to separate one or more organic acids such as lactic acid and acetic acid, thereby more enhancing the antihistaminic action. The addition of at least one organic acid to the extract immediately after extraction can also enhance the antihistiminic action. When rainbow trout or broilers are fed diets containing histamine, this extract significantly relieves the action of histamine. The extract also represses symptoms such as flare, itch and pain caused by excessive release of activated histamine or a histaminic substance, thus providing an antihistaminic substance of natural origin having no side effects.

Abstract: A medicine for skin diseases contains a fermented and condensed extract from the stems of Stevia Rebaudiana Bertoni as an active ingredient. The medicine is prepared by condensing and fermenting an extract from the ripened stems of Stevia Rebaudiana Bertoni by multi-stage condensation followed by fermentation and ripening of the condensed extract. It is effective for various skin diseases and other diseases caused by blood circulation insufficiency.

Abstract: A liquid internal medicine contains only an extract from stems of natural Stevia plants. The medicine is particularly effective for curing disorders of the digestive organs. The medicine contains a liquid obtained by fermenting a concentrate of an extract from Stevia stems, and is administered to patients as is or after dilution. As the medicine contains only the natural component, it is free of any side effects when applied to patients.

Abstract: A liquid internal medicine for domestic animals contains only an extract from stems of natural Stevia plants. The medicine is effective for curing disorders of the digestive organs of domestic animals and for improving the physical constitution of domestic animals to further result in improvement of meat quality, milk quality and hair gloss of domestic animals and promotion of the estrous cycle and their establishment of the menstrual function. The medicine contains a liquid obtained by fermenting a concentrate of an extract from Stevia stems, and is administered to domestic animals as is or after dilution. As the medicine contains only the natural component, it is free of any side effects when applied to domestic animals.