Patents Assigned to Napo Pharmaceuticals, Inc.
-
Patent number: 11857510Abstract: Presented herein are methods and compositions for treating congenital diarrheal disorders (CDD). Methods comprise administering to a patient in need thereof, an effective amount of a proanthocyanidin polymer composition from C. lechleri, preferably crofelemer. Administration of the proanthocyanidin polymer composition addresses the secretory diarrhea and symptoms associated therewith caused by the CDD and can improve nutritional status, electrolyte balance, hydration, growth and development of the patient.Type: GrantFiled: May 31, 2018Date of Patent: January 2, 2024Assignee: NAPO PHARMACEUTICALS, INC.Inventors: Lisa A. Conte, Pravin R. Chaturvedi
-
Patent number: 11779564Abstract: Presented herein are methods for treating bile acid diarrhea, short bowel syndrome (SBS), and cholecystectomy-associated diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. In particular embodiments, infants, and juveniles with SBS are treated with an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.Type: GrantFiled: May 31, 2018Date of Patent: October 10, 2023Assignee: NAPO PHARMACEUTICALS, INC.Inventors: Lisa A. Conte, Pravin R. Chaturvedi, Charles Conte
-
Patent number: 11389424Abstract: Presented herein are methods for treating diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.Type: GrantFiled: March 9, 2018Date of Patent: July 19, 2022Assignee: NAPO PHARMACEUTICALS, INC.Inventor: Lisa A. Conte
-
Patent number: 9987250Abstract: The present invention provides methods for preventing colon cancer by administering, to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to prevent colon cancer, which composition inhibits COX-2. The present invention also provides methods for treating inflammation locally in the intestines comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat inflammation. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. The present invention in alternative embodiments provides methods for treating pain locally in the intestines and treating inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, as well as for treating familial adenomatous polyposis (FAP).Type: GrantFiled: September 3, 2014Date of Patent: June 5, 2018Assignee: NAPO PHARMACEUTICALS, INC.Inventor: Barry D. Quart
-
Patent number: 9980938Abstract: The present invention provides methods for treating diarrhea-predominant irritable bowel syndrome comprising administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea-predominant irritable bowel syndrome (d-IBS). Treatment of d-IBS includes the treatment of the diarrhea component of d-IBS as well as the pain, abdominal discomfort and other symptoms associated with d-IBS. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.Type: GrantFiled: August 22, 2014Date of Patent: May 29, 2018Assignee: NAPO PHARMACEUTICALS, INC.Inventors: Barry D. Quart, David Rosenbaum, Thomas Neenan, Robert C. Blanks
-
Patent number: 9585868Abstract: Presented herein are methods for treating diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.Type: GrantFiled: January 15, 2015Date of Patent: March 7, 2017Assignee: NAPO PHARMACEUTICALS, INC.Inventors: William Forbes, Enoch Bortey, Steven King, Pravin Chaturvedi
-
Patent number: 9314437Abstract: The present invention relates generally to compositions and methods for oral delivery of nordihydroguaiaretic acid (NDGA). More particularly, the present invention relates to pharmacologically optimized multimodal drug delivery systems for orally administered NDGA and methods for preparation and use thereof.Type: GrantFiled: April 23, 2012Date of Patent: April 19, 2016Assignee: NAPO PHARMACEUTICALS, INC.Inventor: Pravin R. Chaturvedi
-
Patent number: 9198879Abstract: The present invention relates generally to compositions and methods for oral delivery of nordihydroguaiaretic acid (NDGA). More particularly, the present invention relates to pharmacologically optimized multimodal drug delivery systems for orally administered NDGA and methods for preparation and use thereof.Type: GrantFiled: June 6, 2013Date of Patent: December 1, 2015Assignee: NAPO PHARMACEUTICALS, INC.Inventor: Pravin R. Chaturvedi
-
Patent number: 9138450Abstract: The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. The present invention in an alternative embodiment also provides methods for treating alternating constipation-predominant/diarrhea-predominant irritable bowel syndrome.Type: GrantFiled: October 12, 2011Date of Patent: September 22, 2015Assignee: Napo Pharmaceuticals, Inc.Inventors: Barry D. Quart, David P. Rosenbaum
-
Patent number: 8962680Abstract: Presented herein are methods for treating diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.Type: GrantFiled: October 31, 2011Date of Patent: February 24, 2015Assignees: Salix Pharmaceuticals, Ltd., Napo Pharmaceuticals, Inc.Inventors: William Forbes, Enoch Bortey, Steven King, Pravin Chaturvedi
-
Patent number: 8852649Abstract: Methods for treating colon cancer include administering, to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat colon cancer, which composition inhibits COX-2. Methods for treating inflammation locally in the intestines comprise administering, to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat inflammation. In one embodiment, the polymeric proanthocyanidin compound is crofelemer.Type: GrantFiled: April 30, 2007Date of Patent: October 7, 2014Assignee: Napo Pharmaceuticals, Inc.Inventor: Barry D. Quart
-
Patent number: 8846113Abstract: The present invention provides methods for treating diarrhea-predominant irritable bowel syndrome comprising administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea-predominant irritable bowel syndrome (d-IBS). Treatment of d-IBS includes the treatment of the diarrhea component of d-IBS as well as the pain, abdominal discomfort and other symptoms associated with d-IBS. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.Type: GrantFiled: November 25, 2011Date of Patent: September 30, 2014Assignee: Napo Pharmaceuticals, Inc.Inventors: Barry Quart, David Rosenbaum, Thomas Neenan, Robert Blanks
-
Publication number: 20130274346Abstract: The present invention relates generally to compositions and methods for oral delivery of nordihydroguaiaretic acid (NDGA). More particularly, the present invention relates to pharmacologically optimized multimodal drug delivery systems for orally administered NDGA and methods for preparation and use thereof.Type: ApplicationFiled: June 6, 2013Publication date: October 17, 2013Applicant: NAPO PHARMACEUTICALS, INC.Inventor: Pravin R. CHATURVEDI
-
Publication number: 20130011478Abstract: The present invention relates generally to compositions and methods for oral delivery of nordihydroguaiaretic acid (NDGA). More particularly, the present invention relates to pharmacologically optimized multimodal drug delivery systems for orally administered NDGA and methods for preparation and use thereof.Type: ApplicationFiled: April 23, 2012Publication date: January 10, 2013Applicant: NAPO PHARMACEUTICALS, INC.Inventor: Pravin R. CHATURVEDI
-
Publication number: 20120202876Abstract: Disclosed herein are methods of treating diseases including gastrointestinal disorders, such as secretory diarrheas, with the proanthocyanidin oligomer, crofelemer. Also disclosed is the anti-secretory effect of crofelemer on Calcium-activated chloride channels (CaCC) and Cystic fibrosis transmembrane conductance regulator (CFTR).Type: ApplicationFiled: October 5, 2010Publication date: August 9, 2012Applicants: NAPO PHARMACEUTICALS, INC., REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Alan S. Verkman, Pravin Chaturvedi, Lukmanee Tradtrantip, Wan Namkung
-
Publication number: 20120128797Abstract: The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. The present invention in an alternative embodiment also provides methods for treating alternating constipation-predominant/diarrhea-predominant irritable bowel syndrome.Type: ApplicationFiled: October 12, 2011Publication date: May 24, 2012Applicant: NAPO PHARMACEUTICALS, INC.Inventors: BARRY D. QUART, DAVID P. ROSENBAUM
-
Publication number: 20090238901Abstract: The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. The present invention in an alternative embodiment also provides methods for treating alternating constipation-predominant/diarrhea-predominant irritable bowel syndrome.Type: ApplicationFiled: June 2, 2009Publication date: September 24, 2009Applicant: NAPO PHARMACEUTICALS, INC.Inventors: Barry D. Quart, David P. Rosenbaum
-
Patent number: 7556831Abstract: Methods for treating constipation-predominant irritable bowel syndrome comprise administering to a patient in need thereof a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. In addition, methods for treating alternating constipation-predominant/diarrhea-predominant irritable bowel syndrome are an alternative embodiment of the invention.Type: GrantFiled: April 30, 2007Date of Patent: July 7, 2009Assignee: Napo Pharmaceuticals, Inc.Inventors: Barry D. Quart, David P. Rosenbaum
-
Patent number: 7341744Abstract: Pharmaceutical compositions containing a proanthocyanidin polymer composition which are useful for the treatment and prevention of secretory diarrhea are provided. The invention specifically relates to pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from a Croton spp. or a Calophyllum spp. In particular, the invention relates to a formulation of a proanthocyanidin polymer composition which protects the composition from the effects of stomach acid after oral administration, particularly to those formulations which are enteric coated. The invention also relates to methods of producing a directly compressible proanthocyanidin polymer composition, as well as compositions containing the directly compressible proanthocyanidin polymer composition.Type: GrantFiled: November 14, 2000Date of Patent: March 11, 2008Assignee: Napo Pharmaceuticals, Inc.Inventors: Edward James Rozhon, Atul S. Khandwala, Akram Sabouni, Gul P. Balwani, Jody Wai-Han Chan, David F. Sesin
-
Patent number: 7323195Abstract: Pharmaceutical compositions containing a proanthocyanidin polymer composition which are useful for the treatment and prevention of secretory diarrhea are provided. The invention specifically relates to pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from a Croton spp. or a Calophyllum spp. In particular, the invention relates to a formulation of a proanthocyanidin polymer composition which protects the composition from the effects of stomach acid after oral administration, particularly to those formulations which are enteric coated. The invention also relates to methods of producing a directly compressible proanthocyanidin polymer composition, as well as compositions containing the directly compressible proanthocyanidin polymer composition.Type: GrantFiled: August 17, 2004Date of Patent: January 29, 2008Assignee: Napo Pharmaceuticals, Inc.Inventors: Edward James Rozhon, Atul S. Khandwala, Akram Sabouni, Gul P. Balwani, Jody Wai-Han Chan, David F. Sesin