Abstract: This invention provides a drug nanoparticle 7 obtained by irradiating laser beam 3 to a solid target 2 composed of drug powder so as to release the drug as downsized component particle from the solid target 2, wherein the drug nanoparticles 7 has an average diameter of 100 nm or less. According to the above structure, there can be provided: a drug nanoparticle having a high bioavailability, a high purity and an excellent handling property in a case where the drug nanoparticle is used as medical agent, agricultural chemical (agrichemical), chemical fertilizer or the like. The method of manufacturing the drug and the medical agent manufacturing apparatus are capable of effectively manufacturing the drug nanoparticles through simple manufacturing steps.

Abstract: It is an object of the present invention to provide a particle crushing and sizing apparatus having a sufficiently wide particle crushing and sizing range, capable of being scaled down in size, and having high processing throughput. To achieve the object, a particle crushing and sizing apparatus has, in a casing 1a, a horizontally provided drive shaft 2, a plurality of circular plates 10 fixedly supported with intervals at the drive shaft 2, and stators 5 arranged so as to be opposed to plate faces 10a at lower peripheral edges of the circular plates 10 and each having inclined faces 5b that cause a gap between the plate faces 10a of the circular plates 10 to become narrower toward peripheral edges of the plate faces 10a.

Abstract: A part of an outer wall composing a clean box 2 becomes a component of a particle processing apparatus, a processing chamber 31 and the clean box 2 are integrated, the entire apparatus can be made compact, and in accordance with such compactness, even when a shaft sealing means 6 and an oil sealing means 323 are disposed in proximity to each other, reliable shaft sealing performance is secured, whereby a shaft sealing structure enabling processing of fine particles by high speed rotation is provided. Furthermore, integration of setting means for components accompanied with assembly and disassembly of the processing chamber is achieved, the entire assembling structure is simplified and the assembly work is made easier, whereby a particle processing apparatus the assembly and disassembly of which accompanied with cleaning work can be easily carried out in a short time without loss of productive efficiency.

Abstract: The present invention relates to a rotating fluidized bed apparatus for powder particle. A gas circulation path is formed at the periphery of the treatment chamber 2 via the circumferential faceplate 202, 212, and the circumferential faceplate is adapted to rotate around an axis. Behavior of powder particles can be controlled by introducing gas from the periphery of the treatment chamber via the circumferential plate 212 to exert centripetal force on the powder particle, while exerting centrifugal force on the powder particles accompanying rotation of the circumferential plate 212.

Abstract: The present invention provides a method of synthesizing hydroxy apatite comprising the steps of preparing a mixed material slurry by dispersing calcium hydroxide (Ca(OH)2) powder into a phosphoric acid (H3PO4) solution; conducting a mechanochemical milling treatment in which shearing force and compressive force based on a centrifugal force of a mechanical rotating body are imparted to the mixed material slurry, and reacting the calcium hydrate component with the phosphoric acid component under normal temperature and pressure thereby to prepare hydroxy apatite (HAp) powder having fine crystals. According to the structure described above, there can be provided a method of synthesizing hydroxy apatite having fine and uniform particle size which can be directly synthesized under normal temperature and pressure in a short time through simple and single process.

Abstract: The present invention provides a method of manufacturing calcium phosphate powder comprising the steps of preparing a mixed material by mixing calcium hydroxide (Ca(OH)2) powder and calcium hydrogenphosphate powder so that a molar ratio (Ca/P) of calcium to phosphor is set to a range of 1.45-1.72; conducting a mixing/milling treatment to the mixed material to cause a soft-mechanochemical compositing reaction thereby to prepare a calcium phosphate precursor; and conducting a heat treatment to thus obtained precursor at a temperature of 600° C. or more thereby to prepare calcium phosphate powder. According to the present invention, the manufacturing process is simple and the manufacturing cost can be remarkably reduced. In addition, fine calcium phosphate powder excellent in characteristics can be easily manufactured in a short time.

Abstract: The object is that of providing a granular material processing apparatus (1) capable of evenly applying energy such as the compressive force and shearing force of pressers (5), due to centrifugal force, while maintaining good circulation conditions for the swirl flow of granular material within a casing (3) wherein, even in cases where granular material for which it is difficult to control the flow thereof in the casing (3) is processed, this is not allowed to accumulate in once place within the casing (3), but is moved to the entire interior wall thereof. In the cylindrical region formed in accordance with the revolution of the pressers (5) in the casing (3), an empty region (6) is formed wherein there is no extension of a shaft (201) etc.

Abstract: The invention relates to a composite solid particle obtained by sticking fine particles on the surface of a core particle by applying impact and then allowing a crystal of a fine particle component to grow on the fine particle-core particle composite with the stuck fine particles described above being used as crystal nuclei and to a production process for the same.

Abstract: A crushing and particle sizing apparatus for granular material in which the particle size can be controlled without the use of a screen or similar apparatus. A gap region is formed as a particle size adjusting region which allows particles suited to the gap setting to pass. Particles not suited to the gap setting are brought into rotational contact with a rotating body and crushed to the suited gap setting.

Abstract: The present invention provides a particulate drying method and drying apparatus, which can disperse particulates in the drying apparatus, prolong the particulate residence time, and improve the drying conditions, while retaining the advantages of conventional flash dryers.

Abstract: The invention relates to a composite solid particle obtained by sticking fine particles on the surface of a core particle by applying impact and then allowing a crystal of a fine particle component to grow on the fine particle-core particle composite with the stuck fine particles described above being used as crystal nuclei and to a production process for the same.

Abstract: The present invention provides a method of producing composite oxide ceramics which is capable of efficiently producing single-phase multi-component metal oxide ceramics having less impurity phase and excellent dielectric characteristics, by a simple process comprising sintering at a low temperature. The method has the steps of mixing a metallic hydroxide or hydrous gel with a plurality of metallic oxide powders to prepare a raw material mixture powder, activating the raw material mixture powder by mechanochemical treatment for grinding the raw material mixture powder with a degree of impact, which provides a centrifugal effect of 15 or more, to form a precursor, and synthesizing composite oxide ceramics by heat treatment of the activated raw material mixture powder (precursor).

Abstract: A continuous method for the surface treatment of solid particles comprises feeding a powder mixture which consists of solid particles of a given substance and solid particles of another substance into one of a plurality of impact chambers in communication with one another and equipped with a rotating disc having impact pins and also with an impingement ring, subjecting the mixture to an impact striking action, separating an air stream produced by that action from the powder mixture and discharging it continuously from the impact chamber, repeating the impact action while allowing the powder mixture to reside temporarily in the impact chamber, and then causing the mixture to move, in succession, to the next chamber and so forth.

Abstract: A continuous method for the surface treatment of solid particles comprises feeding a powder mixture which consists of solid particles of a given substance and solid particles of another substance into one of a plurality of impact chambers in communication with one another and equipped with a rotating disc having impact pins and also with an impingement ring, subjecting the mixture to an impact striking action, separating an air stream produced by that action from the powder mixture and discharging it continuously from the impact chamber, repeating the impact action while allowing the powder mixture to reside temporarily in the impact chamber, and then causing the mixture to move, in succession, to the next chamber and so forth.

Abstract: The present invention is directed to a method for preparing composite particles by fixing, on the surface of a thermoplastic substance having an average particle diameter of 100 .mu.m to 10 mm, a substance having a smaller size and more excellent heat resistance than the thermoplastic substance, the method being characterized by comprising the steps of heating the substance having a smaller size and more excellent heat resistance than the thermoplastic substance up to a temperature of not less than a softening point of the thermoplastic substance with stirring in an apparatus having a stirring mechanism and a heating mechanism; putting the thermoplastic substance in the apparatus; and then fixing the substance having the excellent heat resistance on the surface of the thermoplastic substance.

Abstract: This invention relates to a granular material processing machine characterized by the presence of a reviving main shaft in the center of a container, and the installation of multiple sub-shafts supported around the said main shaft at certain intervals, wherein multiple ring-shaped parts are fitted to said sub-shafts so that there will be sufficient space among the sub-shafts, and said ring-shaped parts are made to come into contact with the inner walls of the container.

Abstract: A method for increasing the proportion of a crystalline organic compound which remains amorphous and suppressing recrystallization in which a crystalline organic compound and a hydrophilic polymer substance are fixed onto a surface of core particles by means of impacts applied in a high velocity gas stream. The solubility and stability of the resulting composite product, such as a drug for internal use, can be improved.

Abstract: A method of improving the quality of the surface of solid particles is disclosed. The method includes fixing material different from the solid particles to the surface of the solid particles by the use of an impact striking device. The material fixed to the solid particles can be other solid particles or particles contained in a liquid, which forms a film.

Abstract: An impact crushing machine for finely and effectively pulverizing materials includes impact plates disposed on one side of a rotary plate and classifying blades disposed on the other side of the rotary plate. A fine grain exhaust outlet and a coarse grain exhaust outlet are disposed facing to the classifying blades. The coarse grain outlet is directly coupled with a supply path for the materials to form a circulating path, and a raw material supply pipe is coupled with the supply path.

Abstract: A mixer-granulator drier comprises a mixer-granulator having main and auxiliary mixing-granulating blades mounted in a vessel forming the main body so that both the blades are revolved to accomplish mixing and granulation of powders as desired. The bottom plate of the vessel is formed with a number of slots, a valve mechanism for opening and closing the slots are located adjacent the slots, and a drying-air supply device is provided for supplying the vessel with drying air through the slots. This combination apparatus performs mixing, granulation, and drying of various drugs, foods, chemicals, etc., in a single vessel automatically and continuously. The apparatus is easy to disassemble for thorough cleaning and sterilization.