Abstract: The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MT1 receptor antagonist, and a method for producing a specific tyrosine derivative with high yield by efficiently introducing an iodine atom at the para position of the phenolic hydroxy group in the benzene ring of tyrosine with good regioselectivity. The tyrosine derivative of the present invention is characterized in being represented by the following formula (I): wherein R1 is a protective group of the amino group and the like; R2 is a protective group of the carboxy group and the like; R3 is a hydrogen atom and the like; R4 is a halogen atom and the like; A is —(CH2)l—[Z(CH2)m]n—; X is a leaving group.

Abstract: The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MT1 receptor antagonist, and a method for producing a specific tyrosine derivative with high yield by efficiently introducing an iodine atom at the para position of the phenolic hydroxy group in the benzene ring of tyrosine with good regioselectivity. The tyrosine derivative of the present invention is characterized in being represented by the following formula (I): wherein R1 is a protective group of the amino group and the like; R2 is a protective group of the carboxy group and the like; R3 is a hydrogen atom and the like; R4 is a halogen atom and the like; A is —(CH2)l—[Z(CH2)m]n—; X is a leaving group.

Abstract: An electrode active material is based on an organic compound containing in the structural unit thereof a pyrazine structure bound to cycloalkane. The electrode active material and a secondary battery containing it have large energy density, outputting high power, and having excellent cycle characteristics with little reduction in capacity even after repetition of charging and discharging.

Abstract: It is intended to provide a method for easily detecting a phosphorylated peptide (protein) in a test sample by using SDS-polyacrylamide gel electrophoresis (SDS-PAGE) which has been conventionally employed in analyzing a protein; a polyacrylamide gel for electrophoresis to be used in the method; a method of producing the gel; and a synthesizing intermediate in producing the gel. The polyacrylamide gel for electrophoresis to be used in the method of the invention is characterized in that at least a part of the structure thereof has a structure represented by the following formula (I); wherein M2+represents a transition metal ion; and X represents a linker group.

Abstract: The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound.

Abstract: The present invention provides a method for confirming existence of a phosphoric acid monoester compound (peptide, saccharine and the like) and easily identifying the molecular weight thereof even among biological samples including a plurality of compounds, and an additive for a mass spectrometry used for the method. In the method according to the present invention, a complex compound exhibiting extremely high coordination ability to a phosphoric acid monoester group and configured of single kind of zinc isotopes is used to obtain a plurality of mass spectrum data, and then the data are compared.

Abstract: A resin having a formula of ##SPC1##Wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is hydrogen or methyl group, each of R.sup.7, R.sup.8, R.sup.9 and R.sup.10 is hydrogen, alkyl group having 1 to 6 carbon atoms or phenyl group and X is -CN, -CONH.sub.2, -COOM or -COOR.sup.a, M being hydrogen, -NH.sub.4 or alkali metal, R.sup.a being alkyl group having 1 to 4 carbon atoms; and a method for manufacturing the same, said resin being usable as substitutes for resin and its derivatives.

Abstract: An alicyclic amino compound of the general formula: ##SPC1##Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are each hydrogen, alkyl having 1 to 6 carbon atoms or phenyl; X is each hydrogen, alkyl having 1 to 6 carbon atoms or aminomethyl; n is an integer of 1 to 3; double bond may be present between the positions indicated by a dotted line, and their production.

Abstract: A saturated polycyclic carboxylic acid of the general formula: ##SPC1##Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, and R.sub.

Abstract: An alicyclic amino compound of the general formula: ##SPC1##Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each hydrogen or alkyl having 1 to 6 carbon atoms; X is each hydrogen, alkyl having 1 to 6 carbon atoms or aminomethyl; n is an integer of 1 or 2, and their production. The subject compound is useful as a cationic surfactant, complexing agent and intermediate.