Patents Assigned to Narhex Limited
  • Amine derivatives of oxo- and hydroxy- substituted hydrocarbons
    Patent number: 6258806
    Abstract: The present invention discloses the compounds of general formula (1) wherein R1, R2, R3 are optionally substituted carbonyl and amide derivatives which are useful as inhibitors of retroviral proteases, and are effective in treating conditions characterized by unwanted activity of these enzymes, such as acquired immune deficiency syndrome.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: July 10, 2001
    Assignee: Narhex Limited
    Inventor: Damian Wojciech Grobelny
  • Polar-substituted hydrocarbons
    Patent number: 6071895
    Abstract: The present invention discloses the compounds of general formula (1) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are optionally substituted carbonyl and amide derivatives which are useful as inhibitors of retroviral proteases, and are effective in treating conditions characterized by unwanted activity of these enzymes, such as acquired immume deficiency syndrome.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: June 6, 2000
    Assignee: Narhex Limited
    Inventor: Damian Wojciech Grobelny
  • Amine derivatives of oxo- and hydroxy- substituted hydrocarbons
    Patent number: 5942504
    Abstract: The present invention discloses the compounds of general formula (1) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are optionally substituted carbonyl and amide derivatives which are useful as inhibitors of retroviral proteases, and are effective in treating conditions characterized by unwanted activity of these enzymes, such as acquired immune deficiency syndrome.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: August 24, 1999
    Assignee: Narhex Limited
    Inventor: Damian Wojciech Grobelny
  • Polar substituted hydrocarbons
    Patent number: 5888992
    Abstract: The invention relates to retroviral protease inhibitors of the general formula (I): W--(A).sub.n --B--(A*).sub.m --V where W, A, B, A*, V, n and m are as defined herein, including related prodrugs of general formula (I) comprising a solubilizing group which is labile in vivo.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: March 30, 1999
    Assignee: Narhex Limited
    Inventor: Damian Wojciech Grobelny
  • Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
    Patent number: 5679688
    Abstract: The present invention discloses the compounds of general formula (1) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are optionally substituted carbonyl and amide derivatives which are useful as inhibitors of retroviral proteases, and are effective in treating conditions characterized by unwanted activity of these enzymes, such as acquired immune deficiency syndrome.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: October 21, 1997
    Assignee: Narhex Limited
    Inventor: Damian Wojciech Grobelny