Patents Assigned to Narodowy Instytut Leków
  • Derivatives of camptothecin, a method of producing them and their use
    Patent number: 9682992
    Abstract: The subject of the present invention are water-soluble derivatives of camptothecin, their synthesis and use. These compounds exhibit preferable biological properties for use in anti-neoplasm therapy.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: June 20, 2017
    Assignees: INSTYTUT CHEMII ORGANICZNEJ POLSKIEJ AKADE, NARODOWY INSTYTUT LEKÓW
    Inventors: Lech Kozerski, Robert Kawęcki, Beata Naumczuk, Karolina Hyz, Wojciech Bocian, Jerzy Sitkowski, Elżbieta Bednarek, Katarzyna Wiktorska, Katarzyna Lubelska
  • Method of evaluating the therapeutic efficacy of bacteriophages
    Patent number: 9678063
    Abstract: The subject of the present invention is a novel use of a nematode in the evaluation of the therapeutic efficacy of bacteriophage preparations used in, or capable of being used in the treatment of infections caused by pathogenic bacteria in humans or animals.
    Type: Grant
    Filed: July 13, 2013
    Date of Patent: June 13, 2017
    Assignees: Instytut Biochemii i Biofizyki Polskiej Akademii Nauk, Instytut Immunolii i Terapii Doswiadczalnej Polskiej Akademii Nauk, Narodowy Instytut Lekow, Szkola Gowna Gospodarstwa Wiejskiego w Warzawie, Wojskowy Instytut Higieny i Epidemiologii
    Inventors: Malgorzata Lobocka, Aleksandra Glowacka, Kamil Dabrowski, Monika S. Hejnowicz, Agnieszka Gozdek, Beata Weber-Dabrowska, Andrzej Gorski, Joanna Empel, Waleria Hryniewicz, Magdalena Kwiatek, Sylwia Parasion, Romuald Gryko
  • Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition
    Patent number: 9206209
    Abstract: An exemplary emboidment is related to a pharmaceutical composition of the class of nucleotide analogues and antiviral pro-nucleotides useful in partial or complete inhibition of human immunodeficiency virus (HIV). An exemplary embodiment is expressed in the formula (XVI): where X stands for N3 and B stands for thymidine-1-yl, or X stands for H and B stands for uracil-1-yl or adenin-1-yl or hypoxanthin-1-yl.A method of synthesis of the nucleotide analogue using a phosphorylating agent for synthesis of the nucleotide analogue is provided.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: December 8, 2015
    Assignees: INSTYTUT CHEMII BIOORGANICZNEJ PAN, NARODOWY INSTYTUT LEKOW
    Inventors: Adam Kraszewski, Joanna Romanowska, Michal Sobkowski, Agnieszka Szymanska-Michalak, Jacek Stawinski, Jerzy Boryski, Andrzej Lipniacki, Andrzej Piasek
  • DERIVATIVES OF CAMPTOTHECIN, A METHOD OF PRODUCING THEM AND THEIR USE
    Publication number: 20150266888
    Abstract: The subject of the present invention are water-soluble derivatives of camptothecin, their synthesis and use. These compounds exhibit preferable biological properties for use in anti-neoplasm therapy.
    Type: Application
    Filed: October 25, 2013
    Publication date: September 24, 2015
    Applicants: Narodowy Instytut Leków, Instytut Chemii Organicznej Polskiej Akademii Nauk
    Inventors: Lech Kozerski, Robert Kawecki, Beata Naumczuk, Karolina Hyz, Wojciech Bocian, Jerzy Sitkowski, Elzbieta Bednarek, Katarzyna Wiktorska, Katarzyna Lubelska
  • METHOD OF EVALUATING THE THERAPEUTIC EFFICACY OF BACTERIOPHAGES
    Publication number: 20150192569
    Abstract: The subject of the present invention is a novel use of a nematode in the evaluation of the therapeutic efficacy of bacteriophage preparations used in, or capable of being used in the treatment of infections caused by pathogenic bacteria in humans or animals.
    Type: Application
    Filed: July 13, 2013
    Publication date: July 9, 2015
    Applicants: Instytut Biochemii I biofizyki Polskiej Akademii Nauk, Instytut Immunologii I Terapii Doswiadczalnej Polsskiej Akademii Nauk, Narodowy instytut Lekow, Szkola Glowna Gospodarstwa Wiejskiego W Warsszawie, Wojskowy Instytut higieny I Epiemiologii
    Inventors: Malgorzata Lobocka, Aleksandra Glowacka, Kamil Dabrowski, Monika S. Hejnowicz, Agnieszka Gozdek, Beata Weber-Dabrowska, Andrzej Gorski, Joanna Empel, Waleria Hryniewicz, Magdalena Kwiatek, Sylwia Parasion, Romuald Gryko
  • NUCLEOTIDE ANALOGUE, METHOD OF SYNTHESIS OF NUCLEOTIDE ANALOGUE, USE OF NUCLEOTIDE ANALOGUE, ANTIVIRAL PRO-NUCLEOTIDE, PHARMACEUTICAL COMPOSITION
    Publication number: 20130316970
    Abstract: The object of the invention are nucleotide analogues, antiviral pro-nucleotides, a use of nucleotide analogues and pharmaceutical composition, a phosphorylating agent for synthesis of nucleotide analogue, and a method of synthesis of nucleotide analogue. More precisely, the invention applies to the new group of nucleotide analogues and their use in partial or complete inhibition of human immunodeficiency virus (HIV).
    Type: Application
    Filed: October 13, 2011
    Publication date: November 28, 2013
    Applicants: NARODOWY INSTYTUT LEKOW, INSTYTUT CHEMII BIOORGANICZNEJ PAN
    Inventors: Adam Kraszewski, Joanna Romanowska, Michal Sobkowski, Agnieszka Szymanska-Michalak, Jacek Stawinski, Jerzy Boryski, Andrzej Lipniacki, Andrzej Piasek