Patents Assigned to Nation Chiao Tung University
  • Patent number: 9746465
    Abstract: A magnetic bead-based digital microfluidic immunoanalysis device and a method thereof are provided, which includes a lower plate, an upper plate disposed above the lower plate, a separating structure therebetween and a magnet disposed on the upper plate or the lower plate. The lower plate includes a first electrode layer including a plurality of channel electrodes with different sizes. A droplet containing few magnetic beads is adapted to be disposed on the lower plate and corresponding to the channel electrodes. The magnet attracts the magnetic beads to approach to the smaller one of the channel electrodes though a magnetic force, and when a voltage is applied to the first electrode layer, the droplet is divided to a detection portion with the magnetic beads and a waste-liquid portion without the magnetic beads respectively corresponding to the smaller one and the larger one of the channel electrodes through a dual-direction electrowetting-on-dielectric force.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: August 29, 2017
    Assignee: National Chiao Tung University
    Inventors: Wensyang Hsu, Cheng-Yeh Huang, Po-Yen Tsai, Po-Huai Shih, Shih-Kang Fan, Da-Jeng Yao, Cheng-Hsien Liu, Hong-Yuan Huang
  • Patent number: 9741704
    Abstract: A silicon-controlled rectifier (SCR) includes a first-type field, a second-type first field and a second-type second field disconnectedly formed in a first-type well; an entire first-type doped region formed within the first-type field; a segmented second-type doped region formed within the second-type first field; and a segmented first-type doped region formed within the second-type second field.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: August 22, 2017
    Assignees: National Chiao Tung University, Himax Technologies Limited
    Inventors: Chun-Yen Chang, Shiang-Shiou Yen, Shao-Chin Chang, Che-Wei Chiang
  • Patent number: 9738660
    Abstract: The present invention provides a compound of formula (I) or the salt thereof: wherein R is at least one selected from the group consisting of unsubstituted C1-4 alkyl, C1-4 alkyl substituted by C6-18 aryl or —OR1, and —C(?O)Z. The compound is a type-S protein kinase inhibitor, which binds to an ATP-binding site and a substrate-recognition site of a protein kinase simultaneously. The present invention further provides a pharmaceutical composition, which includes a compound of formula (I) or a salt and a pharmaceutically acceptable carrier thereof. The present invention further provides a use of a compound of formula (I) or a salt thereof, which is for the manufacture of a protein kinase inhibitor as a drug.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: August 22, 2017
    Assignee: National Chiao Tung University
    Inventors: Jinn-Moon Yang, Kai-Cheng Hsu, Tzu-Ying Sung, Shen Rong Lin, Yun-Ming Wang, Kuang-Mei Hsu, Hsin-Ping Lin, Wan-Chun Liu
  • Patent number: 9724005
    Abstract: A real-time multi-channel EEG signal processor based on an on-line recursive independent component analysis is provided. A whitening unit generates covariance matrix by computing covariance according to a received sampling signal. A covariance matrix generates a whitening matrix by a computation of an inverse square root matrix calculation unit. An ORICA calculation unit computes the sampling signal and the whitening matrix to obtain a post-whitening sampling signal. The post-whitening sampling signal and an unmixing matrix implement an independent component analysis computation to obtain an independent component data. An ORICA training unit implements training of the unmixing matrix according to the independent component data to generate a new unmixing matrix. The ORICA calculation unit may use the new unmixing matrix to implement an independent component analysis computation. Hardware complexity and power consumption can be reduced by sharing registers and arithmetic calculation units.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: August 8, 2017
    Assignee: National Chiao Tung University
    Inventors: Wai-Chi Fang, Wei-Yeh Shih, Jui-Chieh Liao, Kuan-Ju Huang, Chiu-Kuo Chen, Gert Cauwenberghs, Tzyy-Ping Jung
  • Publication number: 20170222044
    Abstract: Structures and formation methods of a semiconductor device structure are provided. The semiconductor device structure includes a source structure at least partially in a semiconductor substrate. The semiconductor device structure also includes a channel structure over the semiconductor substrate. The source structure is partially covered by the channel structure. The semiconductor device structure further includes a drain structure covering the channel structure. The drain structure and the source structure have different conductivity types. A portion of the channel structure is sandwiched between the source structure and the drain structure. In addition, the semiconductor device structure includes a gate stack partially covering the channel structure.
    Type: Application
    Filed: January 28, 2016
    Publication date: August 3, 2017
    Applicants: Taiwan Semiconductor Manufacturing Co., Ltd., National Chiao Tung University
    Inventors: Steve S. CHUNG, E-Ray HSIEH, Yi-Hsien LIN
  • Patent number: 9716498
    Abstract: An impedance-to-digital converter is provided. A sensible impedance range of the impedance-to-digital converter is adjustable by changing magnitudes of signals inputted thereto.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 25, 2017
    Assignee: National Chiao Tung University
    Inventors: Jin-Chern Chiou, Shun-Hsi Hsu
  • Patent number: 9690180
    Abstract: A prism group including a first, a second, and a third prisms is provided. The first prism has a first light incidence surface, a first light emitting surface, and a first connecting surface. The second prism has a second light incidence surface, a second light emitting surface, and a second connecting surface. The second light incidence surface is located between the first light emitting surface and the second light emitting surface. A first air gap is between the second light incidence surface and the first light emitting surface. The third prism has a third light incidence surface, a third light emitting surface, and a third connecting surface. The third light incidence surface is located between the second light emitting surface and the third light emitting surface. A second air gap is between the third light incidence surface and the second light emitting surface. A projection apparatus is also provided.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: June 27, 2017
    Assignee: National Chiao Tung University
    Inventors: Jui-Wen Pan, Yung-Chih Huang, Ping-Chun Lin, Che-Wen Chiang
  • Patent number: 9674077
    Abstract: The invention discloses a vehicular communication system and a routing method thereof. The routing method includes the following steps. When a first relay node of the relay nodes, which locates in a last road slot of each of the road section, receives the route reply packet, the first relay node is configured to obtain a plurality of moving traces of a plurality of specific relay nodes according to the route reply packet; estimate at least one connection life period related to a plurality of specific road slots according to the moving traces; estimate at least one connection available interval of the specific road section according to the at least one connection life period; and append the at least one connection available interval to the route reply packet and forward the route reply packet.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: June 6, 2017
    Assignee: National Chiao Tung University
    Inventors: Yi-Ling Hsieh, Kuo-Chen Wang
  • Patent number: 9670084
    Abstract: A method for treating wastewater containing TMAH and ammonium nitrogen includes the steps of (a) introducing a first solution which contains ammonium nitrogen but no TMAH into a single reactor with microorganisms comprising nitrifying bacteria and anammox bacteria, and denitrifying the first solution by the microorganisms under a dissolved oxygen concentration ranging from 0.1-0.5 mg/L and a pH value of 7-8; (b) when the denitrification efficiency reaches a steady state, introducing a second solution which contains ammonium nitrogen and TMAH and has a concentration of TMAH lower than 60 mg/L into the reactor; and (c) gradually increasing the concentration of TMAH in the solution to be added into the reactor for several times whenever the denitrification efficiency reaches a steady state. Accordingly, the inhibition of TMAH to the anammox bacteria can be significantly decreased, and both TMAH and the ammonium nitrogen can be treated simultaneously.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: June 6, 2017
    Assignees: Leaderman & Associates Co., Ltd., National Chiao Tung University
    Inventors: Der-Ming Lee, Ming-Kuei Chiang, Chin-Te Chen, Keng-Chuan Sung, Chien-Ju Lan, Jih-Gaw Lin, Ying-Chang Liang
  • Patent number: 9622663
    Abstract: A rotation type optical tomography scanner is provided, including an illuminating unit disposed on a surface of an object-to-be-detected for emitting incident light to tissues under the surface of the object-to-be-detected; a detecting unit disposed on the object-to-be-detected and rotating around the illuminating unit to receive diffuse light diffused from the tissues under the surface of the object-to-be-detected and generate tissue sensing information; and a positioning unit for generating position information of the rotation type optical tomography scanner. The rotation type optical tomography scanner transmits the sensing information and the position information to a remodel module to rebuild the tissue images under the surface of the object-to-be-detected, thereby expanding the scanning range of the object-to-be-detected.
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: April 18, 2017
    Assignee: National Chiao Tung University
    Inventors: Wai-Chi Fang, Tien-Ho Chen, Shih Kang, Shih-Yang Wu, Ching-Ju Cheng
  • Patent number: 9622674
    Abstract: In a method and system for generating twelve-lead ECG signals based on three differential voltages, each of which is defined as a potential difference between two myoelectric signals sensed respectively by two corresponding electrodes that cooperatively constitute a corresponding differential electrode pair and that are disposed on a user's chest at predetermined specific locations, a signal processor generates the twelve-lead ECG signals using a pre-established dynamic system model that is associated with the specific locations of the electrodes on the user's chest and that is configured with temporal and spatial correlations among twelve leads of an ECG.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: April 18, 2017
    Assignee: National Chiao Tung University
    Inventors: Sau-Hsuan Wu, Chih-Hao Hsu
  • Patent number: 9623400
    Abstract: The present invention provides a catalyst for producing hydrogen and a preparing method thereof. The method includes the steps of adding a first metal source, a second metal source, a third metal source and a cerium source into a first organic solvent containing a surfactant to form a colloidal mixture, wherein a metal of the first metal source is a Group IIIB metal; a metal of the second metal source is selected from the group consisting of alkali metals, alkaline earth metals and Group IIIB metals, and a metal of the third metal source is a transition metal; calcining the colloidal mixture to form a metal solid solution; and allowing the metal solid solution to be carried on a carrier to obtain the catalyst. When the catalyst of the present invention is used for an ethanol oxidation reformation, the reaction temperature of the ethanol oxidation reformation can be significantly decreased.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: April 18, 2017
    Assignee: National Chiao Tung University
    Inventors: Chi-Shen Lee, Ping-Wen Tsai, Ho-Chen Hsieh, Yun-Sheng Chen, Yuan-Chia Chang, Sheng-Feng Weng
  • Patent number: 9590105
    Abstract: A semiconductor device and methods of formation are provided. The semiconductor device includes a first metal alloy over a first active region of a fin and a second metal alloy over a second active region of the fin. A conductive layer is over a channel region of the fin. A semiconductive layer is over the conductive layer. The conductive layer over the channel region suppresses current leakage and the semiconductive layer over the conductive layer reduces electro flux from a source to a drain, as compared to a channel region that does not have such a conductive layer or a semiconductive layer over a conductive layer. The semiconductor device having the first metal alloy as at least one of the source or drain requires a lower activation temperature than a semiconductor device that does not have a metal alloy as a source or a drain.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: March 7, 2017
    Assignees: National Chiao-Tung University, Taiwan Semiconductor Manufacturing Company Limited
    Inventors: Chao-Hsin Chien, Cheng-Ting Chung, Che-Wei Chen
  • Patent number: 9573129
    Abstract: A sensing system includes a processing unit and sensor chip. The sensor chip includes a microelectrode array, a droplet space over the microelectrode array, and a plurality of control units coupled together in a daisy-chain configuration. Each of the control units is coupled to a respective one of the microelectrodes of the microelectrode array. The control units are controlled by the processing unit to drive movement of a droplet in the droplet space, and to inspect the droplet via the microelectrodes.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: February 21, 2017
    Assignee: National Chiao Tung University
    Inventors: Chen-Yi Lee, Kelvin Yi-Tse Lai, Yu-Tao Yang
  • Patent number: 9577078
    Abstract: Structures and formation methods of a semiconductor device structure are provided. The semiconductor device structure includes a source structure in a semiconductor substrate. The semiconductor device structure also includes a channel layer over the semiconductor substrate. A first portion of the channel layer covers a portion of the source structure. A second portion of the channel layer laterally extends away from the source structure. The semiconductor device structure further includes a drain structure over the semiconductor substrate. The drain structure and the source structure have different conductivity types. The drain structure adjoins the second portion of the channel layer.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: February 21, 2017
    Assignees: Taiwan Semiconductor Manufacturing Co., Ltd., National Chiao Tung University
    Inventors: Steve S. Chung, E-Ray Hsieh, Yu-Bin Zhao, Samuel C. Pan
  • Patent number: 9568586
    Abstract: A method for positioning a device includes the steps of: estimating an absolute distance between a reference point and the device at each of a current time point and a number (N) of consecutive previous time points, where N is a integer smaller than n, n is a non-negative integer indicating a total number of time points since the device starting to move, and the current time point is defined as the (n)th time point; estimating a unit vector of a movement direction of the device in each of (n?N+1)th to (n)th time periods; and estimating a coordinate of a location of the device at (n)th time point based on the absolute distance(s), the unit vector(s), and a coordinate of a location of the device at each of the number (N) of the consecutive previous time points.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: February 14, 2017
    Assignee: National Chiao Tung University
    Inventors: Jwu-Sheng Hu, Kuan-Chun Sun
  • Patent number: 9570091
    Abstract: A music playing system and a music playing method suitable for playing music based on speech emotion recognition are provided. The music playing method includes following steps. A plurality of songs and song emotion coordinates of the songs mapping on an emotion coordinate graph are stored in a first database. Emotion recognition parameters are stored in a second database. A voice data is received and analyzed, and a current emotion coordinate of the voice data mapping on the emotion coordinate graph is obtained according to the second database. The setting of a target emotion coordinate is received. At least one specific song emotion coordinate closest to a cheer-up line connecting the current emotion coordinate and the target emotion coordinate is found. Songs corresponding to aforementioned emotion coordinates are sequentially played.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: February 14, 2017
    Assignee: National Chiao Tung University
    Inventors: Kai-Tai Song, Carlos Cervantes
  • Publication number: 20170027877
    Abstract: The present invention provides a method for preparing a drug composition, which includes steps of dispersing an amphiphilic chitosan derivative, at least a hydrophobic drug, and at least a hydrophilic drug into a solvent to form a mixture solution, and the pH value of the mixture solution is adjusted to a range without precipitating the hydrophilic drug(s) and the hydrophobic drug(s), wherein the amphiphilic chitosan derivative is modified by a plurality of hydrophilic group(s) and a plurality of hydrophobic group(s); and after stirring the mixture solution for at least 12 hours, receiving the drug composition when the pH value of the mixture solution is between pH 6 to 7. The hydrophilic drug(s) and the hydrophobic drug(s) are encapsulated simultaneously by one-pot synthesis, and the protein could be modified by one-pot synthesis to provide a drug composition with multiple functions.
    Type: Application
    Filed: November 6, 2015
    Publication date: February 2, 2017
    Applicant: National Chiao Tung University
    Inventors: Wei-Ting Huang, Yi-Chi Lee, Dean-Mo Liu
  • Patent number: 9553199
    Abstract: Semiconductor devices and methods of forming the same are provided. A source/drain electrode stack is formed over a substrate, wherein the source/drain electrode stack comprises a first source/drain electrode and a second source/drain electrode. A source/channel/drain layer is formed on a sidewall of the source/drain electrode stack, wherein the source/channel/drain layer comprises a 2D material. A gate stack is formed on the source/channel/drain layer.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: January 24, 2017
    Assignees: Taiwan Semiconductor Manufacturing Company, Ltd., National Chiao Tung University
    Inventors: Tuo-Hung Hou, Samuel C. Pan
  • Patent number: 9552625
    Abstract: A method, image processing apparatus, and computer readable medium for image enhancement are provided. In the method, a low-resolution image is received and upscaled to generate an upscaled image having first pixels. Edge detection is performed on the upscaled image to obtain edge information of the first pixels. Each piece of the edge information includes an edge direction and an edge intensity, and each of the edge directions includes a horizontal and vertical component having a constant summation. A non-edge region of the upscaled image is enhanced to generate a high-resolution detail image; based on unsharp masking sharpening methods, an edge region of the low-passed upscaled image is enhanced according to the horizontal and vertical components of the edge directions to generate a high-resolution edge image. Image fusion is performed on the high-resolution edge image and the high-resolution detail image according to the edge intensities to generate a super-resolution image.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: January 24, 2017
    Assignee: National Chiao Tung University
    Inventors: Kuo-Shiuan Peng, Fang-Cheng Lin, Yi-Pai Huang, Han-Ping D. Shieh