Patents Assigned to NATIONAL BRAIN RESEARCH CENTRE
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Patent number: 11372068Abstract: It is an integrative platform for visualization, preprocessing and quantitation of MRS data acquired using single voxel, multi voxel magnetic resonance spectroscopy imaging (MRSI) and MEshcher-GArwood Point-RESolved Spectroscopy (MEGA-PRESS) acquisition methods. The method integrates both time- and frequency-domain signal processing methods on a single platform. The method is optimized for proton (1H) and phosphorous (31P) MRS data. It employs the use of iterative baseline estimation and fitting procedure to provide improved quantitation accuracy. The method can be used in both interactive and automatic mode to cater to the needs of researchers and clinicians.Type: GrantFiled: August 19, 2016Date of Patent: June 28, 2022Assignees: Secretary, Department of Electronics and Information Technology (DEITY), National Brain Research CentreInventors: Pravat K. Mandal, Monika Grewal, Shammi More, Sumiti Saharan, Deepika Shukla
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Publication number: 20210190891Abstract: It is an integrative platform for visualization, preprocessing and quantitation of MRS data acquired using single voxel, multi voxel magnetic resonance spectroscopy imaging (MRSI) and MEshcher-GArwood Point-RESolved Spectroscopy (MEGA-PRESS) acquisition methods. The method integrates both time- and frequency-domain signal processing methods on a single platform. The method is optimized for proton (1H) and phosphorous (31P) MRS data. It employs the use of iterative baseline estimation and fitting procedure to provide improved quantitation accuracy. The method can be used in both interactive and automatic mode to cater to the needs of researchers and clinicians.Type: ApplicationFiled: August 19, 2016Publication date: June 24, 2021Applicants: SECRETARY, DEPARTMENT OF ELECTRONICS AND INFORMATION TECHNOLOGY (DEITY), National Brain Research CentreInventors: Pravat K. MANDAL, Monika GREWAL, Shammi MORE, Sumiti SAHARAN, Deepika SHUKLA
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Patent number: 9868960Abstract: The present invention relates to cell specific therapeutic modality by using a region of the PLAP Promoter. The invention further relates to specific expression of therapeutically PLAP useful sequences for specific transcriptional activation of this gene. The invention also relates to the PLAP region which may be used alone or in combination with other regions like enhancer sequences that augment cell or tumour specific gene expression.Type: GrantFiled: May 10, 2014Date of Patent: January 16, 2018Assignees: National Brain Research Centre, All India Institute of Medical SciencesInventors: Subrata Sinha, Imran Khan, Mohammad Khalid Zakaria, Kunzang Chosdol, Parthaprasad Chattopadhyay
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Patent number: 9556437Abstract: The present invention demonstrates for the first time that FAT1 plays an important role in modulating PDCD4 expression, which in turn regulates AP-1 dependent transcription, controls processes crucial for migration and invasion in cancer cells, controls induction of a pro-inflammatory micro environment in cancer cells. The study illustrates a link between inflammation and cancer in cells or in a subject. This work highlights the importance of FAT1 in the induction of the cellular pathways of migration and invasion, proteolysis of the ECM and the expression of pro-inflammatory molecules leading to a favorable micro environment for tumor and cancer progression.Type: GrantFiled: July 3, 2014Date of Patent: January 31, 2017Assignees: DEPARTMENT OF BIOTECHNOLOGY (DBT), ALL INDIA INSTITUTE OF MEDIAL SCIENCES (AIIMS), NATIONAL BRAIN RESEARCH CENTRE (NBRC)Inventors: Kunzang Chosdol, Bhawana Dikshit, Subrata Sinha
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Patent number: 8804906Abstract: This invention relates to a technique to enhance the clinical efficiency of radiotherapy and readiosurgery using perturbative beaming and tissue specific radiobiology, comprising, Considering the normal steady beam dose rate, then increasing the temporal stochastic fluctuation of the output intensity of the radiation beam from a medical linear accelerator or cobalt gamma knife beam setup, developing a computer-based methodology by considering the tumor specific radiobiology and magnitude of the tailor made dose rate fluctuation using an embedded system device consisting of requisite hardware and software as described herein.Type: GrantFiled: February 10, 2009Date of Patent: August 12, 2014Assignees: Department of Biotechnology, National Brain Research CentreInventors: Prasun Roy, Subhadip Paul
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Patent number: 8774480Abstract: A method for medical image enhancement based on image transform resonance. A novel method for Stochastic Resonance of medical image enhancement device based on the Integral Transform of the image, comprising: generating specific types of integral transforms like radon transform for CT, Fourier transform for MRI with image transform component; preparing stochastic perturbation waveform, with perturbator component performing the stochastic resonance on the image transform, with stochastic resonator component; characterizing the image enhancement factor of the SR-processed image with performance monitoring component; adjusting and controlling the bistability parameters of the double-well system that induces stochastic resonance with control component; arranging the provisional display of the array matrix of the SR-enhanced images, as the bistability parameters are varied with matrix display component; subjecting the final image to the step of display with final image display component.Type: GrantFiled: February 10, 2009Date of Patent: July 8, 2014Assignees: Department of Biotechnology, National Brain Research CentreInventors: Prasun Roy, V. P. Subramanyam Rallabandi
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Patent number: 8577106Abstract: The invention relates to a fully automated screening, diagnosis and classification technique for Alzheimer's disease using magnetic resonance imaging signals from the ventricular zone contour of the brain to get a fundamental index of brain deterioration comprising the steps: —obtaining a gray scale MRI image of the brain region; —applying a contour edge-detecting algorithm to the image; —employing a grid covering method for calculating a first order metric index of ventricular zone contour; —superimposing metric square grids of increasing edge length to the binary contour image and counting the metric grid squares; —plotting the logs of metric grid squares against the logs of edge lengths, wherein the gradient of the plot is the linear topological metric index.Type: GrantFiled: February 10, 2009Date of Patent: November 5, 2013Assignees: Department of Biotechnology, National Brain Research CentreInventors: Prasun Roy, Subramanyam V. P. Rallabandi
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Patent number: 8481087Abstract: The present invention provides Withania somnifera plant extract and composition comprising the extract useful for the treatment of neurodegenerative disease and/or disorders such as Alzheimers disease (AD). The present invention further provides a process for preparation of the extract.Type: GrantFiled: July 29, 2009Date of Patent: July 9, 2013Assignees: National Brain Research Centre, Indian Institute of Science, Molecular Biophysics Unit, University of Delhi, Department of ChemistryInventors: Vijayalaksmi Ravindranath, Alok Gupta, Neha Sehgal, Subhash Chand Jain, Suman Thakur, Pankaj Khanna
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Publication number: 20120106703Abstract: This invention relates to a technique to enhance the clinical efficiency of radiotherapy and readiosurgery using perturbative beaming and tissue specific radiobiology, comprising, Considering the normal steady beam dose rate, then increasing the temporal stochastic fluctuation of the output intensity of the radiation beam from a medical linear accelerator or cobalt gamma knife beam setup, developing a computer-based methodology by considering the tumor specific radiobiology and magnitude of the tailor made dose rate fluctuation using an embedded system device consisting of requisite hardware and software as described herein.Type: ApplicationFiled: February 10, 2009Publication date: May 3, 2012Applicants: NATIONAL BRAIN RESEARCH CENTRE, DEPARTMENT OF BIOTECHNOLOGYInventors: Prasun Roy, Subhadip Paul
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Publication number: 20110286650Abstract: The invention relates to a fully automated screening, diagnosis and classification technique for Alzheimer's disease using magnetic resonance imaging signals from the ventricular zone contour of the brain to get a fundamental index of brain deterioration comprising the steps: —obtaining a gray scale MRI image of the brain region; —applying a contour edge-detecting algorithm to the image; —employing a grid covering method for calculating a first order metric index of ventricular zone contour; —superimposing metric square grids of increasing edge length to the binary contour image and counting the metric grid squares; —plotting the logs of metric grid squares against the logs of edge lengths, wherein the gradient of the plot is the linear topological metric index.Type: ApplicationFiled: February 10, 2009Publication date: November 24, 2011Applicants: NATIONAL BRAIN RESEARCH CENTRE, DEPARTMENT OF BIOTECHNOLOGYInventors: Prasun Roy, Subramanyam V.P. Rallabandi
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Publication number: 20110116699Abstract: A method for medical image enhancement based on image transform resonance A novel method for Stochastic Resonance of medical image enhancement device based on the Integral Transform of the image, comprising: generating specific types of integral transforms like radon transform for CT, Fourier transform for MRI with image transform component; preparing stochastic perturbation waveform, with perturbator component performing the stochastic resonance on the image transform, with stochastic resonator component; characterizing the image enhancement factor of the SR-processed image with performance monitoring component; adjusting and controlling the bistability parameters of the double-well system that induces stochastic resonance with control component; arranging the provisional display of the array matrix of the SR-enhanced images, as the bistability parameters are varied with matrix display component; subjecting the final image to the step of display with final image display component.Type: ApplicationFiled: February 10, 2009Publication date: May 19, 2011Applicants: NATIONAL BRAIN RESEARCH CENTRE, Department of BiotechnologyInventors: Prasun Roy, V. P. Subramanyam Rallabandi
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Publication number: 20110054040Abstract: This invention relates to a Bicyclic triterpenoid Iripallidal as a novel anti-glioma and anti neoplastic agent, having the composition [(?)(6R,10S,11S,18R,22S)-26 Hydroxy-22-? methylcyloirid-16-enal NSC 631939], wherein it binds to Ras GRP3, a phorbol ester receptor that links DAG/phorbolester signaling with Ras activation and induces phosphorylation of ER K1/2 in a Ras dependent manner, reducing proliferation of cancer cell lines to the extent of 50-70%.Type: ApplicationFiled: June 11, 2009Publication date: March 3, 2011Applicants: DEPARTMENT OF BIOTECHNOLOGY, NATIONAL BRAIN RESEARCH CENTREInventors: Ellora Sen, Nitin Koul, Vivek Sharma, Richa Tewari
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Publication number: 20100329989Abstract: A method for specifically labeling of mammalian cone photoreceptors in vivo comprising injecting a mammal with peanut agglutinin conjugated with a fluorescent probe. The peanut agglutinin labels the cone photoreceptor.Type: ApplicationFiled: May 21, 2008Publication date: December 30, 2010Applicants: DEPARTMENT OF BIOTECHNOLOGY, NATIONAL BRAIN RESEARCH CENTREInventors: Narender K. Dhingra, K. Vidhyasankar