Patents Assigned to National Cancer Center
  • Blood cell aggregating agent for preparing paraffin block and method for preparing paraffin block by using same
    Patent number: 10656058
    Abstract: The present invention relates to a material for aggregating blood cells, used in the preparation of a paraffin block for diagnosing circulating tumor cells (CTCs), and a method for preparing a paraffin block using the same, and more specifically, to a method for detecting CTCs present in the blood through blood sample collection in the preparation of a paraffin block from CTCs, which are present in a very small amount in the blood. The present invention is non-invasive and simple, and thus is very useful for the diagnosis of cancer recurrence and metastatic cancer and for prognosis prediction, and can be a remarkable breakthrough in cancer treatment through the analysis of the onset, metastasis and recurrence mechanisms of cancer.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: May 19, 2020
    Assignee: NATIONAL CANCER CENTER
    Inventors: Hee Jin Chang, Sun Young Kim, Ji Yeon Baek, Hyun Yang Yeo
  • FUCOIDAN-BASED THERAGNOSTIC COMPOSITION
    Publication number: 20200147217
    Abstract: The present invention relates to a fucoidan-based theragnostic composition, and more particularly, to preparation and use of a theragnostic composition which uses a conjugate of a fluorescent dye or a photosensitizer and fucoidan, thereby not only allowing for fluorescence imaging diagnosis of lesions for cancer or vascular diseases but also allowing a therapeutic effect thereon to be obtained at the same time. The conjugate obtained by covalent bonding of a fluorescent dye or a photosensitizer and fucoidan, according to the present invention, is not only useful for fluorescence imaging diagnosis of tumor tissues and ophthalmic vascular diseases, but also may exhibit a therapeutic effect on cancer cells and coronary artery smooth muscle cells, and a neovascularization inhibitory effect in ophthalmic diseases.
    Type: Application
    Filed: November 7, 2019
    Publication date: May 14, 2020
    Applicant: National Cancer Center
    Inventors: Yong Doo CHOI, Mi Hyeon Cho, Yan Li
  • Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound
    Patent number: 10646460
    Abstract: The present invention relates to a pharmaceutical composition for inhibiting growth of cancer stem cells, containing an aldehyde inhibitor and a biguanide-based compound. The pharmaceutical composition according to the present invention contains a combination of an aldehyde inhibitor and a biguanide-based compound, which can effectively inhibit the growth of cancer stem cells such as neurospheres and can also inhibit the proliferation, invasion and metastasis of cancer cells, thereby preventing and/or treating cancer such as brain cancer.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: May 12, 2020
    Assignee: National Cancer Center
    Inventors: Seok Gu Kang, Jong Hee Chang, Eui Hyun Kim, Ji Hyun Lee, Yun Hee Jo, Junseong Park, Jin Kyoung Shim, Soo Youl Kim
  • KIT, DEVICE, AND METHOD FOR DETECTING LUNG CANCER
    Publication number: 20200140958
    Abstract: This application provides a kit or a device for detection of lung cancer, comprising a nucleic acid(s) for detecting a miRNA(s) in a sample from a subject, and a method for detecting lung cancer, comprising measuring the miRNA(s) in vitro.
    Type: Application
    Filed: June 29, 2018
    Publication date: May 7, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Yuho KIDA, Satoko KOZONO, Hiroko SUDO, Satoshi KONDOU, Junpei KAWAUCHI, Takahiro OCHIYA, Shun-ichi WATANABE
  • KIT, DEVICE, AND METHOD FOR DETECTING OVARIAN TUMOR
    Publication number: 20200140956
    Abstract: This application provides a kit or a device for detection of ovarian tumor, comprising a nucleic acid(s) for detecting a miRNA(s) in a sample from a subject, and a method for detecting ovarian tumor, comprising measuring the miRNA(s) in vitro.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 7, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Yuho KIDA, Satoko KOZONO, Hiroko SUDO, Satoshi KONDOU, Junpei KAWAUCHI, Hitoshi NOBUMASA, Takahiro OCHIYA, Tomoyasu KATO
  • INFORMATION PROCESSING APPARATUS, CONTROL METHOD, AND PROGRAM
    Publication number: 20200129042
    Abstract: An information processing apparatus (2000) detects an abnormal region (30) from video data (12). The information processing apparatus (2000) displays a video frame (14) in which the abnormal region (30) is detected in a first region (22) of a display device (20). Further, the information processing apparatus (2000) displays the video data (12) including the video frame (14) generated after the video frame (14) displayed in the first region in a second region (24) of the display device (20).
    Type: Application
    Filed: May 18, 2018
    Publication date: April 30, 2020
    Applicants: NEC CORPORATION, NATIONAL CANCER CENTER
    Inventors: Ikuma TAKAHASHI, Maki SANO, Motoyasu OKUTSU, Chiemi TANAKA, Masahiro SAIKOU, Hitoshi IMAOKA, Kenichi KAMIJO, Yutaka SAITO, Masayoshi YAMADA
  • Biliary tract cancer detection kit or device, and detection method
    Patent number: 10633708
    Abstract: The present invention provides a kit or device for the detection of biliary tract cancer, and a method for detecting biliary tract cancer. The present invention relates to a kit or device for the detection of biliary tract cancer, comprising a nucleic acid capable of specifically binding to miRNA in a sample of a subject, and a method for detecting biliary tract cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: April 28, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Junpei Kawauchi, Hitoshi Nobumasa, Satoko Kozono, Satoshi Kondou, Hiroko Sudo, Atsushi Ochiai, Motohiro Kojima
  • Composition comprising of a conducting polymer for detecting, capturing, releasing, and collecting cell
    Patent number: 10634670
    Abstract: The present invention relates to a composition in which a conducting polymer is doped with a dopant, and a diagnostic apparatus, and more particularly, to a composition which is used to diagnose a disease and detect a biomaterial and also used for qualification and diagnosis by effectively and non-destructively collecting a captured biomaterial. Further, the composition can maximize capturing efficiency by being attached to a surface of a nano-structured scaffold and can be used as an ultrahigh-sensitive sensor using various linked bodies.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: April 28, 2020
    Assignee: National Cancer Center
    Inventor: Young-Nam Cho
  • KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR
    Publication number: 20200115758
    Abstract: This application provides a kit or a device for the detection of early pancreatic cancer or a pancreatic cancer precursor lesion, comprising a nucleic acid(s) capable of specifically binding to a miRNA(s) in a sample from a subject, and a method for detecting early pancreatic cancer or a pancreatic cancer precursor lesion, comprising measuring an expression level(s) of the miRNA(s) in vitro.
    Type: Application
    Filed: March 31, 2017
    Publication date: April 16, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Junpei KAWAUCHI, Hiroko SUDO, Satoko KOZONO, Atsushi OCHIAI, Motohiro KOJIMA
  • Lung cancer detection kit or device, and detection method
    Patent number: 10620228
    Abstract: It is intended to provide a kit or a device for the detection of lung cancer and a method for detecting lung cancer. The present invention provides a kit or a device for the detection of lung cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample from a subject, and a method for detecting lung cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: April 14, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Hiroko Sudo, Hitoshi Nobumasa, Satoko Kozono, Satoshi Kondou, Junpei Kawauchi, Atsushi Ochiai, Motohiro Kojima
  • Method for detecting OCLN-ARHGAP26 gene
    Patent number: 10619184
    Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an OCLN gene and a part of an ARHGAP26 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding OCLN and an antisense primer designed from a section encoding ARHGAP26.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: April 14, 2020
    Assignees: Astellas Pharma Inc., National Cancer Center
    Inventors: Hiroki Sasaki, Hitoshi Ichikawa, Makoto Asaumi, Kazuhisa Tsunoyama
  • Prostate cancer detection kit or device, and detection method
    Patent number: 10619213
    Abstract: An object of the present invention is to provide a kit or a device for the detection of prostate cancer and a method for detecting prostate cancer. The present invention provides a kit or a device for the detection of prostate cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample of a subject, and a method for detecting prostate cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: April 14, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi Kondou, Hitoshi Nobumasa, Satoko Kozono, Hiroko Sudo, Junpei Kawauchi, Takahiro Ochiya, Nobuyoshi Kosaka
  • Method for detecting RP2-ARHGAP6 gene
    Patent number: 10619216
    Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an RP2 gene and a part of an ARHGAP6 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding RP2 and an antisense primer designed from a section encoding ARHGAP6.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: April 14, 2020
    Assignees: Astellas Pharma Inc., National Cancer Center
    Inventors: Hiroki Sasaki, Hitoshi Ichikawa
  • Esophageal cancer detection kit or device, and detection method
    Patent number: 10619212
    Abstract: It is intended to provide a kit or a device for the detection of esophageal cancer and a method for detecting esophageal cancer. The present invention provides a kit or a device for the detection of esophageal cancer, comprising nucleic acid(s) capable of specifically binding to miRNA(s) in a sample f a subject, and a method for detecting esophageal cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: April 14, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Hiroko Sudo, Hitoshi Nobumasa, Satoko Kozono, Satoshi Kondou, Junpei Kawauchi, Atsushi Ochiai, Motohiro Kojima
  • X-ray CT apparatus including processing circuitry to perform a metal-artifact reducing process
    Patent number: 10610185
    Abstract: An X-ray CT apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to detect X-rays that have passed through a subject by using a detector and to acquire projection data on a basis of a detection result. The processing circuitry is configured to obtain position information of a highly X-ray absorbent member in the body of the subject. The processing circuitry is configured to derive information about transmission paths of the X-rays in accordance with a processing effect of an artifact reducing process performed on the highly X-ray absorbent member, on the basis of the position information of the highly X-ray absorbent member.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: April 7, 2020
    Assignees: Canon Medical Systems Corporation, National Cancer Center
    Inventors: Hiroki Taguchi, Shinsuke Tsukagoshi, Kotaro Sekiya, Hirofumi Kuno, Keiichi Nomura
  • Colorectal cancer detection kit or device, and detection method
    Patent number: 10604810
    Abstract: It is intended to provide a kit or a device for the detection of colorectal cancer and a method for detecting colorectal cancer. The present invention provides a kit or a device for the detection of colorectal cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample from a subject, and a method for detecting colorectal cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: March 31, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoko Kozono, Hitoshi Nobumasa, Satoshi Kondou, Hiroko Sudo, Junpei Kawauchi, Atsushi Ochiai, Motohiro Kojima
  • Breast cancer detection kit or device, and detection method
    Patent number: 10597726
    Abstract: It is intended to provide a kit or a device for the detection of breast cancer and a method for detecting breast cancer. The present invention provides a kit or a device for the detection of breast cancer, comprising nucleic acid(s) capable of specifically binding to a miRNA in a sample of a subject, and a method for detecting breast cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: March 24, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi Kondou, Hitoshi Nobumasa, Satoko Kozono, Hiroko Sudo, Junpei Kawauchi, Takahiro Ochiya, Nobuyoshi Kosaka, Makiko Ono, Kenji Tamura
  • Stomach cancer detection kit or device, and detection method
    Patent number: 10597727
    Abstract: This invention relates to a kit or a device for the detection of stomach cancer and a method for detecting stomach cancer, and provides a kit or a device for the detection of stomach cancer, comprising a nucleic acid(s) capable of specifically binding to a miRNA(s) in a sample from a subject, and a method for detecting stomach cancer, comprising measuring the miRNA(s) in vitro.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 24, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoko Kozono, Hitoshi Nobumasa, Satoshi Kondou, Hiroko Sudo, Junpei Kawauchi, Atsushi Ochiai, Motohiro Kojima
  • Liver cancer detection kit or device, and detection method
    Patent number: 10590487
    Abstract: It is intended to provide a kit or device for the detection of liver cancer and a method for detecting liver cancer. The present invention relates to a kit or device for the detection of liver cancer, comprising a nucleic acid capable of specifically binding to miRNA in a sample of a subject, and a method for detecting liver cancer, comprising measuring the miRNA in vitro.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: March 17, 2020
    Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTER
    Inventors: Satoshi Kondou, Hitoshi Nobumasa, Satoko Kozono, Hiroko Sudo, Junpei Kawauchi, Atsushi Ochiai, Motohiro Kojima
  • X-RAY CT APPARATUS, MEDICAL IMAGE PROCESSING APPARATUS, AND X-RAY CT SYSTEM
    Publication number: 20200082579
    Abstract: An X-ray CT apparatus according to an embodiment includes processing circuitry. The processing circuitry acquires a first data set corresponding to first X-ray energy and a second data set corresponding to second X-ray energy different from the first X-ray energy, with respect to a region including a part of a subject by performing scanning using X-rays. The processing circuitry generates a scatter diagram representing a contained amount of each of reference materials at each of positions in the region on the basis of the first data set and the second data set. The processing circuitry sets weights for at least a part of the scatter diagram. The processing circuitry generates an analysis image based on the contained amounts and the weights.
    Type: Application
    Filed: September 6, 2019
    Publication date: March 12, 2020
    Applicants: CANON MEDICAL SYSTEMS CORPORATION, National Cancer Center
    Inventors: Kotaro Sekiya, Hirofumi Kuno, Takashi Hiyama, Tsubomi Hashizume, So Tsushima, Shinsuke Tsukagoshi