Patents Assigned to National Center for Biological Sciences
  • Method for determining agent capacity to alter pH using poly dA nucleic acid switches
    Patent number: 9772336
    Abstract: Disclosed are nucleic acid-based molecular switches that respond to changes in pH. The switches may be used in DNA nanodevices. The switches may also act as sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The switch includes an A-motif that forms at acidic pH. Also disclosed are compositions and methods for measuring the pH of cells or regions thereof, such as vesicles, the nucleus, mitochondrial matrix, or the Golgi lumen.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: September 26, 2017
    Assignee: NATIONAL CENTER FOR BIOLOGICAL SCIENCES
    Inventors: Yamuna Krishnan, Saikat Chakraborty
  • Store-operated calcium cellular assay
    Patent number: 8906604
    Abstract: The present technology provides a cell based assay for identifying compounds that modulate store-operated ionic calcium levels using itpr mutant cell lines, such as itpr-ku cells, which have abnormal ionic calcium levels.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: December 9, 2014
    Assignee: National Center for Biological Sciences
    Inventors: Gayatri Venkiteswaran, Gaiti Hasan
  • STORE-OPERATED CALCIUM CELLULAR ASSAY
    Publication number: 20130260409
    Abstract: The present technology provides a cell based assay for identifying compounds that modulate store-operated ionic calcium levels using itpr mutant cell lines, such as itpr-ku cells, which have abnormal ionic calcium levels.
    Type: Application
    Filed: June 11, 2013
    Publication date: October 3, 2013
    Applicant: National Center for Biological Sciences
    Inventors: Gayatri Venkiteswaran, Gaiti Hasan
  • Store-operated calcium cellular assay
    Patent number: 8476006
    Abstract: The present technology provides a cell based assay for identifying compounds that modulate store-operated ionic calcium levels using itpr mutant cell lines, such as itpr-ku cells, which have abnormal ionic calcium levels.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: July 2, 2013
    Assignee: National Center for Biological Sciences
    Inventors: Gayatri Venkiteswaran, Gaiti Hasan
  • DNA-based molecular switches and uses thereof
    Patent number: 8216850
    Abstract: Disclosed are nucleic acid-based molecular switches that respond to changes in pH. The switches may be used in DNA nanodevices. The switches may also act as sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The switch includes an A-motif that forms at acidic pH. Also disclosed are compositions and methods for measuring the pH of cells or regions thereof, such as vesicles, the nucleus, mitochondrial matrix, or the Golgi lumen.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: July 10, 2012
    Assignee: National Center for Biological Sciences
    Inventors: Yamuna Krishnan, Saikat Chakraborty
  • DNA-based molecular switches and uses thereof
    Patent number: 8153437
    Abstract: Disclosed are nucleic acid-based molecular switches that respond to changes in pH. The switches may be used in DNA nanodevices. The switches may also act as sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The switch includes an A-motif that forms at acidic pH. Also disclosed are compositions and methods for measuring the pH of cells or regions thereof, such as vesicles, the nucleus, mitochondrial matrix, or the Golgi lumen.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: April 10, 2012
    Assignee: National Center for Biological Sciences
    Inventors: Yamuna Krishnan, Saikat Chakraborty