Patents Assigned to National Center for Nanoscience and Technology
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Publication number: 20230181705Abstract: A tumor vaccine, a preparation method therefor, and use of the tumor vaccine thereof. A pharmaceutical combination with a first membrane component having a membrane derived from the inner membrane of bacteria, the pharmaceutical combination further includes components derived from other organisms than the bacteria. A method for enhancing an uptake of a target antigen by an immune cell, activating an immune cell, enhancing an innate immunity and/or a specific immune response and/or preventing and/or treating a tumor. A tumor vaccine for preventing postoperative recurrence of cancer.Type: ApplicationFiled: May 17, 2021Publication date: June 15, 2023Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGYInventors: Guangjun NIE, Ruifang ZHAO, Long CHEN, Hao QIN, Yuliang ZHAO
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Patent number: 11369302Abstract: Disclosed are an implantable flexible neural microelectrode comb, and a preparation method and implantation method therefor. The flexible neural microelectrode comb is mainly composed of a flexible substrate layer (1), a flexible insulation layer (2), and a metal connection wire layer (3) arranged between the flexible substrate layer (1) and the flexible insulation layer (2); the flexible neural microelectrode comb comprises a filament structure (4), a mesh structure (5), a plane structure (6) and a bonding pad area (7) connected in sequence; electrode sites (8) are arranged on the filament structure (4); bonding pads are arranged on the bonding pad area (7); the metal connection wire layer (3) is composed of metal connection wires connecting the electrode sites (8) and the bonding pads; and the flexible insulation layer (2) is not arranged on the surfaces of the electrode sites (8) and the bonding pads.Type: GrantFiled: February 6, 2017Date of Patent: June 28, 2022Assignee: National Center for Nanoscience and Technology, ChinaInventors: Ying Fang, Jinfen Wang, Shouliang Guan, Mingde Du, Liang Zou
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Publication number: 20210404891Abstract: The present disclosure generally relates to pressure detection technology, and in particular, to a pressure sensor, a method of fabricating a pressure sensor, and a pressure detecting device. The pressure sensor may include a flexible nanopaper, and a graphene film on one side of the flexible nanopaper.Type: ApplicationFiled: December 25, 2018Publication date: December 30, 2021Applicants: BOE TECHNOLOGY GROUP CO., LTD., NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGYInventors: Hongbian Li, Jidong Shi, Kairan Liu, Chunyan Ji, Xinguo Li, Wenbo Li
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Patent number: 10823758Abstract: Provided is a conical nano-carbon material functionalized needle tip, formed by assembling a nano-carbon material with a material of a needle tip by means of a covalent bond; and the material of the needle tip is a metal selected from one or more of tungsten, iron, cobalt, nickel and titanium. Further provided is a method for preparing the conical nano-carbon material functionalized needle tip. The conical nano-material functionalized needle tip has an outstanding interface formed by metal-carbide covalent bonds, and the orientation of the conical nano-material is matched with the axial direction of the metal needle tip (illustrated in FIG. 6). The proposed preparation method affords a robust interface and avoids the potential pollution to the nano-material caused during the deposition of fixing materials, such as carbon or platinum or the like, in other preparation methods.Type: GrantFiled: March 29, 2016Date of Patent: November 3, 2020Assignee: National Center for Nanoscience and TechnologyInventors: Jianxun Xu, Yuliang Zhao
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Patent number: 10607805Abstract: Disclosed are a filament positioning system and a filament positioning method. The filament positioning system includes a bottom plate, a first positioning regulating mechanism and a second positioning regulating mechanism, wherein the first positioning regulating mechanism is configured to conduct positioning regulation of a position of a filament seat on the bottom plate, so that filament seats of different models can be fixed to the bottom plate, and the second positioning regulating mechanism is configured to conduct positioning regulation on the filament; and a detection module configured to collect and display position information of a filament tip and the filament seat, wherein the first positioning regulating mechanism and the second positioning regulating mechanism correspondingly regulate positions of the filament seat and the filament tip according to the position information.Type: GrantFiled: December 7, 2017Date of Patent: March 31, 2020Assignee: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY, CHINAInventors: Xixue Hu, Hongbo Guo, Dongliang Wang, Yaling Gan, Xiaohui Xu
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Publication number: 20190313933Abstract: Disclosed are an implantable flexible neural microelectrode comb, and a preparation method and implantation method therefor. The flexible neural microelectrode comb is mainly composed of a flexible substrate layer (1), a flexible insulation layer (2), and a metal connection wire layer (3) arranged between the flexible substrate layer (1) and the flexible insulation layer (2); the flexible neural microelectrode comb comprises a filament structure (4), a mesh structure (5), a plane structure (6) and a bonding pad area (7) connected in sequence; electrode sites (8) are arranged on the filament structure (4); bonding pads are arranged on the bonding pad area (7); the metal connection wire layer (3) is composed of metal connection wires connecting the electrode sites (8) and the bonding pads; and the flexible insulation layer (2) is not arranged on the surfaces of the electrode sites (8) and the bonding pads.Type: ApplicationFiled: February 6, 2017Publication date: October 17, 2019Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY, CHINAInventors: Ying FANG, Jinfen WANG, Shouliang GUAN, Mingde DU, Liang ZOU
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Patent number: 10258669Abstract: A group of polypeptides and a complex formed by the polypeptides and human serum albumin, a method for improving the solubility of the group of polypeptides in a salt solution by combining the polypeptides with human serum albumin, a method for preparing the complex formed by the group of polypeptides and human serum albumin, and an application of the group of polypeptides and the complex formed by the polypeptides and human serum albumin in the preparation of drugs for suppressing tumor metastasis and treating leukemia are described.Type: GrantFiled: July 1, 2015Date of Patent: April 16, 2019Assignees: National Center for Nanoscience and Technology, China, Institute of Basic Medical Sciences, Chinese Academy of Medical SciencesInventors: Chen Wang, Hongyang Duan, Yanlian Yang, Haiyan Xu, Xiaojin Li, Hua Guo, Hanyi Xie, Yue Yu
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Publication number: 20190107556Abstract: Provided is a conical nano-carbon material functionalized needle tip, formed by assembling a nano-carbon material with a material of a needle tip by means of a covalent bond; and the material of the needle tip is a metal selected from one or more of tungsten, iron, cobalt, nickel and titanium. Further provided is a method for preparing the conical nano-carbon material functionalized needle tip. The conical nano-material functionalized needle tip has an outstanding interface formed by metal-carbide covalent bonds, and the orientation of the conical nano-material is matched with the axial direction of the metal needle tip (illustrated in FIG. 6). The proposed preparation method affords a robust interface and avoids the potential pollution to the nano-material caused during the deposition of fixing materials, such as carbon or platinum or the like, in other preparation methods.Type: ApplicationFiled: March 29, 2016Publication date: April 11, 2019Applicants: National Center for Nanoscience and Technology, National Center for Nanoscience and TechnologyInventors: Jianxun Xu, Yuliang Zhao
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Patent number: 9526771Abstract: The present invention provides a preparation method of an antigen composition. The preparation method comprises the following steps: (1) obtaining a tumor antigen protein; (2) making the tumor antigen protein into contact with an immature dendritic cell; (3) inducing the immature dendritic cell in contact with the tumor antigen into a mature dendritic cell; and (4) separating a cell vesicle of the mature dendritic cell. The present invention further provides an antigen composition obtained through the preparation method and the application thereof in preparing a tumor vaccine.Type: GrantFiled: February 4, 2013Date of Patent: December 27, 2016Assignee: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGYInventors: Guangjun Nie, Xin Tian, Motao Zhu
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Patent number: 9404153Abstract: A detection method of nucleic acid is provided. The method includes: providing nucleic acid to be tested, making the nucleic acid to be tested react under asymmetric PCR conditions with a pair of primers for target nucleic acid amplification, DNA polymerase, adenine deoxyribonucleotide, guanine deoxyribonucleotide, cytosine deoxyribonucleotide and thymidine deoxyribonucleotide in a PCR buffer solution, mixing the reaction product and liquid that contains probe molecules, and judging whether the nucleic acid to be tested contains the target nucleic acid by observing the obtained mixture color or color change. A kit is also provided that can be used in the nucleic acid detection by the said method. Application of the method and the kit in inspection and quarantine is also provided. The method is a quick and easy, sensitive and a specific detection method of nucleic acid with direct observation using naked eyes. The method does not need additional equipment.Type: GrantFiled: April 12, 2011Date of Patent: August 2, 2016Assignees: National Center for Nanoscience and Technology, Beijing Entry-Exit Inspection and Quarantine BureauInventors: Xingjie Liang, Hua Deng, Xiaowei Ma, Chan Li
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Patent number: 9196465Abstract: A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile.Type: GrantFiled: June 1, 2012Date of Patent: November 24, 2015Assignee: National Center for Nanoscience and TechnologyInventors: Guangjun Nie, Tony Hu, Jia Fan, Yuliang Zhao, Mauro Ferrari
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Publication number: 20150291429Abstract: Provided is a method for treating single-walled carbon nanotube, comprising: (1) allowing single-walled carbon nanotubes to contact with a surfactant and a dispersant sequentially in the present of a solvent, to obtain highly dispersed single-walled carbon nanotubes in which the content of single dispersed single-walled carbon nanotubes is not lower than 50 wt %, wherein, the single-walled carbon nanotubes can be dispersed in the solvent, and the surfactant and dispersant can be dissolved in the solvent; (2) employing density gradient centrifugation to sort the highly dispersed single-walled carbon nanotubes obtained in step (1). This method can effectively separate single-walled carbon nanotubes with different structural properties.Type: ApplicationFiled: July 27, 2012Publication date: October 15, 2015Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGYInventors: Guanglu Ge, Lirong Wang, Xue Xue, Xingjie Liang
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Publication number: 20150093415Abstract: The present invention provides a preparation method of an antigen composition. The preparation method comprises the following steps: (1) obtaining a tumor antigen protein; (2) making the tumor antigen protein into contact with an immature dendritic cell; (3) inducing the immature dendritic cell in contact with the tumor antigen into a mature dendritic cell; and (4) separating a cell vesicle of the mature dendritic cell. The present invention further provides an antigen composition obtained through the preparation method and the application thereof in preparing a tumor vaccine.Type: ApplicationFiled: February 4, 2013Publication date: April 2, 2015Applicant: National Center for Nanoscience and TechnologyInventors: Guangjun Nie, Xin Tian, Motao Zhu
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Patent number: 8836931Abstract: The present disclosure provides a detection system for acquiring the SPR angle, including a modulatable SPR sensor to be detected; an incident light source apparatus; a photoelectric detector; a narrowband filter system; a modulated signal source for generating an alternating current signal that is used to modulate said modulatable SPR sensor; and a data processing system for recording the corresponding relationship between the incident angle and the intensity of the filtered reflected light and further obtaining the resonance angle of said modulatable SPR sensor. The present disclosure also provides a corresponding detection method for acquiring the SPR angle.Type: GrantFiled: October 28, 2008Date of Patent: September 16, 2014Assignees: National Center for Nanoscience and Technology, China, Beihang UniversityInventors: Kun Wang, Jinsong Zhu, Zheng Zheng, Jiangfeng Fan
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Publication number: 20140217277Abstract: A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile.Type: ApplicationFiled: June 1, 2012Publication date: August 7, 2014Applicant: National Center for Nanoscience and TechnologyInventors: Guangjun Nie, Tony Hu, Jia Fan, Yuliang Zhao, Mauro Ferrari
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Publication number: 20140017671Abstract: A detection method of nucleic acid is provided. The method includes: providing nucleic acid to be tested, making the nucleic acid to be tested react under asymmetric PCR conditions with a pair of primers for target nucleic acid amplification, DNA polymerase, adenine deoxyribonucleotide, guanine deoxyribonucleotide, cytosine deoxyribonucleotide and thymidine deoxyribonucleotide in a PCR buffer solution, mixing the reaction product and liquid that contains probe molecules, and judging whether the nucleic acid to be tested contains the target nucleic acid by observing the obtained mixture color or color change. A kit is also provided that can be used in the nucleic acid detection by the said method. Application of the method and the kit in inspection and quarantine is also provided. The method is a quick and easy, sensitive and a specific detection method of nucleic acid with direct observation using naked eyes. The method does not need additional equipment.Type: ApplicationFiled: April 12, 2011Publication date: January 16, 2014Applicants: BEIJING ENTRY-EXIT INSPECTION AND QUARANTINE BUREAU, P. R. CHINA, NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGYInventors: Xingjie Liang, Hua Deng, Xiaowei Ma
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Patent number: 8416416Abstract: The invention provides an SPR measuring method and a measuring system thereof. According to the measuring method, first, a linear-polarized coherent broadband pulsed light beam is incident onto a surface of a sample under detection of a SPR sensing device to cause reflection; next, a time-domain monotonous chirp is performed on the incident coherent broadband pulsed light and/or the SPR reflected light; finally, the time-domain monotonically chirped SPR reflected light beam is detected, and information of the SPR effect is obtained according to the detected signal. According to the invention, the spectrum detection method used in conventional slow wavelength interrogation is converted into the high-speed real-time detection of time-domain pulse shape signals. Thus, the procedure of the SPR reaction may be monitored closely, and dynamical curves with very high time resolution may be obtained, in that case, fast biochemical reaction procedures may be monitored.Type: GrantFiled: November 29, 2007Date of Patent: April 9, 2013Assignees: National Center for Nanoscience and Technology, Beihang UniversityInventors: Zheng Zheng, Yuhang Wan, Xin Zhao, Jinsong Zhu, Jiangfeng Fan
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Publication number: 20130059143Abstract: A method for preparing a graphene based conductive material and the graphene based conductive material prepared by the method. The method includes: preparing a solid film on a substrate layer by using graphene oxide sol and metal salt solution and/or metal colloidal solution, keeping the solid film separated or without separated from the substrate layer standing for from 30 s to 10000 h in an atmosphere consisting of hydrogen or containing hydrogen with temperature of ?50° C.˜200° C. and hydrogen pressure of 0.01-100 MPa, obtaining the graphene based conductive material. The preparation method can be processed at low temperature and uses cheap hydrogen as reductant, so the preparation process is simple and environment friendly.Type: ApplicationFiled: May 16, 2011Publication date: March 7, 2013Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGYInventors: Minghui Liang, Linjie Zhi
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Patent number: 8133642Abstract: A metal optical grayscale mask includes a layer of metal film which is deposited on transparent substrate, and different transparency pattern which is formed by laser writing on the surface of the metal film. The pattern is continuous, in type of array or random pattern. The grayscale is within 3.0 OD-0.05 OD. The thickness of the metal film is 5-100 nm. A manufacturing method of the metal optical grayscale mask includes that the selected transparent substrate is rinsed by the general semiconductor rinse process, the metal film is deposited on the transparent substrate then different transparency pattern is formed by laser writing on the surface of the metal film. The pattern is continuous, in type of array or the random pattern. The grayscale mask is low in price, antistatic electricity performance is good, the resolution can surpass optical diffraction limit. The manufacturing method is simple.Type: GrantFiled: December 3, 2010Date of Patent: March 13, 2012Assignee: National Center for Nanoscience and TechnologyInventors: Chuanfei Guo, Qian Liu, Sihai Cao, Yongsheng Wang
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Publication number: 20110111331Abstract: A metal optical grayscale mask includes a layer of metal film which is deposited on transparent substrate, and different transparency pattern which is formed by laser writing on the surface of the metal film. The pattern is continuous, in type of array or random pattern. The grayscale is within 3.0 OD-0.05 OD. The thickness of the metal film is 5-100 nm. A manufacturing method of the metal optical grayscale mask includes that the selected transparent substrate is rinsed by the general semiconductor rinse process, the metal film is deposited on the transparent substrate then different transparency pattern is formed by laser writing on the surface of the metal film. The pattern is continuous, in type of array or the random pattern. The grayscale mask is low in price, antistatic electricity performance is good, the resolution can surpass optical diffraction limit. The manufacturing method is simple.Type: ApplicationFiled: December 3, 2010Publication date: May 12, 2011Applicant: National Center for Nanoscience and TechnologyInventors: Chuanfei Guo, Qian Liu, Sihai Cao, Yongsheng Wang