Abstract: Disclosed is a method for producing nanocelluloses from a cellulose substrate including cellulose fibers, the method including the following sequence of steps: a step of enzymatic treatment of the cellulose substrate, by bringing same into contact with at least one cleaving enzyme, then a step of mechanical treatment of the cellulose substrate subjected to the step of enzymatic treatment, in order to delaminate the cellulose fibres and obtain the nanocelluloses. The at least one cleaving enzyme is chosen from the enzymes belonging to the family of lytic polysaccharide monooxygenases (LPMOs) capable of achieving cleavage in the presence of an electron donor. Also disclosed are the nanocelluloses obtained according to the method.
Type:
Application
Filed:
June 1, 2016
Publication date:
May 24, 2018
Applicant:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE-INRA
Inventors:
Bernard CATHALA, Ana VILLARES, Jean-Guy BERRIN, Celine MOREAU
Abstract: Organic oligomers of acylglycerol having general formula (I): Formula (I), in which M1 and Q1 are organic groups; G11 is a hydroxylpropyl group; G12 and G13 are ?/??-acylglycerols; n is a natural integer from the range [0; 8]; m is a natural integer from the range [0; 4]; and p is a natural integer from the range [0; 3].
Type:
Grant
Filed:
March 12, 2014
Date of Patent:
May 1, 2018
Assignees:
Agronutrition, Institut National Polytechnique de Toulouse, Institut National de la Recherche Agronomique
Abstract: The present invention relates to the use of a cysteine endoprotease or a malt extract to prevent or reduce the cloudiness of a cereal-based beverage, fermented or not.
Type:
Application
Filed:
April 29, 2016
Publication date:
April 26, 2018
Applicants:
MALTERIES SOUFFLET, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
Inventors:
Michel LOPEZ, Myriam FLISS, Didier Gilbert MARION
Abstract: A method for the synthesis of ?/??-alcoxylated glycerol linear carbonic esters, wherein the following are brought into contact at a reaction temperature lower than 220° C.: a quantity of at least one precursor selected from the group consisting of ?/??-alcoxylated glycerol cyclo-carbonates; a quantity of at least one catalyst selected from the group consisting of metal oxides, Lewis acids, organometallic catalysts and mineral bases; and a quantity of at least one organic primer. A composition containing at least one novel ?/??-alkoxylated glycerol linear carbonic ester.
Type:
Grant
Filed:
December 20, 2013
Date of Patent:
April 24, 2018
Assignees:
CHRYSO, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
Abstract: The invention relates to a method for obtaining a mutant Yarrowia yeast strain capable of growing on D-galactose as sole carbon source, comprising over expressing in said strain a galactokinase, a galactose-1-phosphate uridyl transferase, an UDP-glucose-4 epimerase and a galactose mutarotase. The invention also relates to a mutant Yarrowia strain obtained by said method.
Type:
Application
Filed:
June 17, 2016
Publication date:
April 12, 2018
Applicant:
Institut National de la Recherche Agronomique
Abstract: The invention relates to a recombinant novirhabdovirus expressing a chimeric protein comprising the sequence of an antigen of interest flanked, at the N-terminus, by a signal peptide, and at the C-terminus, by a polypeptide comprising at least one portion of the transmembrane domain of a rhabdovirus G protein. Said recombinant novirhabdovirus can be used especially for inducing an immune response to the antigen of interest.
Type:
Grant
Filed:
October 8, 2013
Date of Patent:
March 6, 2018
Assignee:
Institut National de la Recherche Agronomique
Abstract: A KISS1R agonist peptide compound capable of inducing ovulation in a female mammal is provided. The compound is a pseudopeptide having the C-terminal sequence: -Xaa?[Tz]Xaa2-Xaa3-Xaa4-NH2 (SEQ ID NO: 3), where ?[Tz] represents a 1,4-disubstituted 1,2,3-triazole group replacing the peptide bond between the Xaa1 residue and the Xaa2 residue, Xaa1 is Gly or Ala, Xaa2 is Leu or an aliphatic ?-aminoacyl analog residue, Xaa3 is Arg, Arg(Me) or a positively charged ?-aminoacyl analog residue, and Xaa4 is Tyr, Phe, Trp or an ?-aminoacyl analog residue such as aryl alanine; or an analog of the pseudopeptide in which the amide peptide bond between Xaa2 and Xaa3 and/or between Xaa3 and Xaa4 is replaced with an isosteric bond, or a salt thereof.
Type:
Grant
Filed:
January 31, 2014
Date of Patent:
February 6, 2018
Assignees:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The process for the dry fractionation of lignocellulosic biomass of at least 50% by weight of lignins, cellulose and hemicelluloses. The biomass is fragmented to obtain an ultrafine powder. The process includes at least one step of separating a fraction enriched with cellulose and a fraction enriched with lignin, hemicelluloses and minerals by electrostatic sorting of the ultrafine particles. Preferably, the fraction separation step includes a step of triboelectrostatic charging of ultrafine particles and at least one step of deviating a path in the electric field of the charged particles to sort the particles.
Type:
Grant
Filed:
December 24, 2014
Date of Patent:
January 30, 2018
Assignees:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CIRAD
Inventors:
Bruno Piriou, Abdellatif Barakat, Xavier Rouau, Gilles Vaitilingom
Abstract: The invention relates to markers for Crohn's disease and to specific compounds for detecting said markers. The invention also relates to methods for detecting, diagnosing and monitoring the progression of Crohn's disease as well as to methods for evaluating the efficacy of a treatment for said disease, and to compositions and kits that can be used for implementing said methods.
Type:
Application
Filed:
December 18, 2015
Publication date:
December 7, 2017
Applicants:
Institut National De La Recherche Agronomique, Centre National De La Recherche Scientifique, Universite De Strasbourg
Inventors:
CATHERINE JUSTE, JOEL DORE, ALAIN GUILLOT, CHRISTINE CARAPITO, ALVARO SEBASTIAN VACA JACOME
Abstract: The use of a polyhydroxylated polyaromatic compound, in particular of chicoric acid, for combating plant pests and phytosanitary composition comprising chicoric acid.
Type:
Grant
Filed:
February 12, 2015
Date of Patent:
November 21, 2017
Assignee:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE-INRA
Abstract: The invention relates to a tandem mass spectrometer comprising an ionization source that can produce ions; a mass analyzer comprising an ion trap arranged in such a way as to receive ions from the ion source and a detector that can detect ions leaving the ion trap according to the mass to charge (m/z) ratio thereof; ion activation means for activating ions that can fragment at least some of the ions trapped in the ion trap; and coupling means arranged between the ion trap and said ion activation means. According to the invention, the ion activation means consists of a glow discharge lamp that can generate a light beam oriented towards the ion trap, said light beam being electromagnetic radiation in the vacuum ultraviolet wavelength range with photon energies of between 8 eV and 41 eV in such a way as to fragment at least some of the ions trapped in the ion trap.
Type:
Grant
Filed:
April 27, 2016
Date of Patent:
October 24, 2017
Assignees:
SYNCHROTRON SOLEIL, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Inventors:
Alexandre Giuliani, Matthieu Refregiers, Aleksandar Milosavljevic, Laurent Nahon
Abstract: A process for treating plants, including the application of at least one compound, termed carbonic ester of glycerol, including at least one carboxylic ester function formed by a carbonic acid-derived group and at least one glycerol-derived group, with the exception of cyclic glyceryl carbonate including five ring members.
Type:
Grant
Filed:
March 12, 2014
Date of Patent:
October 17, 2017
Assignees:
AGRONUTRITION, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Abstract: The invention relates to the use of a grape marc extract in order to stimulate the natural defenses of plants and to a method for stimulating the natural defenses of plants, which comprises the application on said plants of a composition comprising a grape marc extract.
Type:
Grant
Filed:
July 1, 2011
Date of Patent:
October 17, 2017
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE BLAISE PASCAL CLERMONT FERRAND II, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Inventors:
Claire Richard, Alexandra Ter Halle, Pascale Goupil, Gerard Ledoigt, Boris Eyheraguibel, Denis Thiery
Abstract: A pharmaceutical composition for treating viral infections by an influenza type A virus, includes a compound capable of acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of influenza type A viruses, and capable of binding to the viral-RNA-binding domain on the nucleoprotein. A pharmaceutical composition for treating viral infections by an orthomyxovirus, includes a compound capable of acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of orthomyxoviruses, and capable of binding to the viral-RNA-binding domain on the nucleoprotein of the viruses. A compound acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of influenza type A viruses, and binding to the viral-RNA-binding domain on the nucleoprotein of influenza type A viruses and a method for identifying such a compound having these properties are also described.
Type:
Grant
Filed:
April 20, 2012
Date of Patent:
October 10, 2017
Assignee:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Inventors:
Anny Slama Schwok, Bernard Delmas, Stephane Quideau, Helene Bertrand, Bogdan Tarus
Abstract: The invention relates to a dominant mutation in the TDM gene leading to the production of 2n gametes in plants, to the plants comprising said mutation, and to their use in plant breeding. The invention relates also to plants in which the dominant mutation in the TDM gene is combined with the inactivation of a gene involved in meiotic recombination in plants and a gene involved in the monopolar orientation of the kinetochores during meiosis. These plants which produce apomeiotic gametes are also useful in plant breeding.
Type:
Application
Filed:
June 1, 2015
Publication date:
October 5, 2017
Applicant:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Inventors:
Raphaël Mercier, Marta Cifuentes, Laurence Cromer
Abstract: A method for synthesizing dimethyl carbonate from methanol and urea, in which a saline ureic medium is used that includes at least one inorganic salt selected from the group made up of zinc (Zn) (II) chloride, tin (Sn) chlorides and iron (Fe) (III) chloride, characterized in that: methanol, in the presence of a catalytic composition, is placed in contact with the saline ureic medium that is at least partially liquid at a temperature referred to as synthesis temperature, which is higher than 140° C., such that reaction vapors are produced; the reaction vapors are condensed, and a condensate of the reaction vapors is collected, including dimethyl carbonate; the method is carried out at atmospheric pressure. A method for enriching and purifying dimethyl carbonate is also described.
Type:
Grant
Filed:
January 19, 2015
Date of Patent:
September 19, 2017
Assignees:
CHARABOT SA, INSITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Inventors:
Zephirin Mouloungui, Christophe Maruejouls, Sophie Lavoine-Hanneguelle
Abstract: Enzyme compositions including at least a) a cocktail of cellulases from Trichoderma reesei, and b) an enzymatic cocktail from Pycnoporus cinnabarinus including a cellobiose dehydrogenase (CDH) or c) a recombinant cellobiose dehydrogenase (CDH) from Pycnoporus cinnabarinus, preferably also including a Family 61 glycoside hydrolase. Also, methods for degrading a lignocellulosic biomass, for producing a fermentation product, for producing gluconic acid, xylonic acid and/or xylobionic acid, for enhancing the production of gluconic acid, xylonic acid and/or xylobionic acid or for increasing the yield of sugars from a lignocellulosic biomass.
Type:
Grant
Filed:
July 4, 2012
Date of Patent:
June 27, 2017
Assignees:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT FRANCAIS DU PETROLE ENERGIE NOUVELLE, AGRO INDUSTRIES RECHERCHES ET DEVELOPPEMENTS
Inventors:
Jean-Claude Sigoillot, Jean-Guy Berrin, Mathieu Bey
Abstract: The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction thereof, a member of the WAP family proteins or an active fraction thereof or a member of the Serpin family proteins or an active fraction thereof for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction thereof, a gene coding for a member of the WAP family proteins or an active fraction thereof, or a gene coding for a member of the Serpin family proteins or an active fraction thereof.
Type:
Grant
Filed:
September 18, 2014
Date of Patent:
June 27, 2017
Assignees:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), UNIVERSITE PARIS DIDEROT—Paris 7
Inventors:
Nathalie Vergnolle, Jean-Michel Sallenave, Philippe Langella, Luis Bermudez-Humaran
Abstract: The invention relates to a method for producing derivatives of O-?-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is monohydroxylated or hydroxylated in a non-vicinal manner on the B cycle. The invention also relates to novel O-?-glucosylated flavonoid derivatives, and to the use thereof.
Type:
Application
Filed:
March 24, 2015
Publication date:
April 20, 2017
Applicants:
Institut National de la Recherche Agronomique, Institut National des Sciences Appliquees de Toulouse, Centre National de la Recherche Scientifique