Patents Assigned to National de la Recherche Scientifique
  • Patent number: 5219949
    Abstract: A process for cross-linking (co)polymers having ester functions involves reacting a polyalcohol-derived polyester and a polyacid-derived polyester in the presence of an alkaline alcoholate at a temperature in excess of 180.degree. C.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: June 15, 1993
    Assignees: Centre National de la Recherche Scientifique, Sotra Industries
    Inventors: Christian Gondard, Alain Michel
  • Patent number: 5217944
    Abstract: A method for preparing a textured polycrystalline material having, in the crystalline state, a magnetic anisotropy, comprises the following steps:preparing a compound such that, after being molten and solidified, it provides substantially only said material and that, at the melting temperature, crystallites of said material exist;slowly heating close to the melting temperature, up to some degrees above said temperautre, so that it remains crystallites of said material in a liquid phase;slowly cooling close to the melting temperature, up to solidification; andapplying, at least from the time at which the material begins to enter the liquid state up to the time at which it is fully solidified, a magnetic field having a sufficient strength to preferentially orient, despite the thermal agitation energy, crystallites having a sufficient size for constituting crystallization seeds.
    Type: Grant
    Filed: August 1, 1991
    Date of Patent: June 8, 1993
    Assignee: Centre National de la Recherche Scientifique
    Inventor: Robert Tournier
  • Patent number: 5217615
    Abstract: The present invention relates to a process for removing heavy metals and substantially destroying indicator bacteria present in municipal sludges, which comprises: lowering, under aerobic conditions, the pH of a municipal sludge from about 7 to 8 to about 2.0 to 2.5 by adding to said sludge 10% by volume of an inoculum containing a mixture of microorganisms comprising Thiobacillus thiooxidans ATCC 55127 and Thiobacillus thioparus ATCC 55128 with 1 to 3 g per liter of sulphur, and incubating for a period of at least 40 hours where the heavy metals originally present in said sludge have been substantially solubilized and the concentration of the indicator bacteria have been lowered to a non-toxic level; and recovering the metals from the low pH treated sludge of step a).
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: June 8, 1993
    Assignee: Institut National de la Recherche Scientifique
    Inventors: Rajeshwar D. Tyagi, Devender K. Jain, Denis Couillard
  • Patent number: 5208039
    Abstract: Synthetic or semisynthetic nutrient composition intended to inhibit the development and the dissemination of malignant tumors in mammals, which composition is characterized in that it is deprived of methionine and supplemented with homocysteine; and utilization, in the preparation of such nutrient compositions, of a source of amino acids deprived of methionine.
    Type: Grant
    Filed: December 26, 1989
    Date of Patent: May 4, 1993
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Marie-France Poupon, Paule Echinard-Garin, Fabienne R. Breillout
  • Patent number: 5204191
    Abstract: The invention relates to materials for coating metal alloys or metals, which materials are intended to improve the performance of said alloys or metals.These materials have a composition which corresponds to the general formula Al.sub.a Cu.sub.b Fe.sub.c X.sub.d I.sub.e, wherein X represents one or more elements chosen from V, Mo, Ti, Zr, Nb, Cr, Mn, Ru, Rh, Ni, Mg, W, Si and the rare earths, and I represents the inevitable manufacturing impurities, e.ltoreq.2, 14.ltoreq.b.ltoreq.30, 7.ltoreq.c.ltoreq.20, O.ltoreq.d.ltoreq.10, with c+d.ltoreq.10 and a+b+c+d+e=100% of the number of atoms, and they contain at least 40% by mass of an icosahedral quasi-crystalline phase and/or a decagonal quasi-crystalline phase and have a grain size greater than 1,000 nm in the quasi-crystalline phase.These materials are useful, in particular, for coating copper, aluminium alloys or copper alloys in the manufacture of cooking utensils, anti-friction bearings, anti-wear surfaces and reference surfaces.
    Type: Grant
    Filed: January 6, 1992
    Date of Patent: April 20, 1993
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-Marie Dubois, Pierre Weinland
  • Patent number: 5202201
    Abstract: The invention relates to a composite element usable in an electrochemical generator. The element comprises a substrate (1) covered by cathodic sputtering with a layer (5) of amorphous material TiO.sub.a X.sub.B with X=S, Se or Te and0.01<a.ltoreq.2,0.01<b.ltoreq.3,2.ltoreq.a+b.ltoreq.3.The layer (5) consitutes the positive electrode of the generator and it can be associated with a lithium negative electrode (9) and a lithium ion conductive glass electrolyte (7).
    Type: Grant
    Filed: May 2, 1991
    Date of Patent: April 13, 1993
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Georges Meunier, Richard Dormoy, Alain Levasseur
  • Patent number: 5200041
    Abstract: The invention relates to a composite element incorporating a support of an organic, electricity conducting, polyaromatic structure product, such as graphite, covered with a polymer or copolymer of dibenzoethers of formula: ##STR1## in which m=0 or 1 to 10, n=0 or 1 to 10, m+n.ltoreq.10, p=0 or 1 to 6, R.sup.1 =alkyl or aryl, R.sup.2 =alkyl or aryl.These elements are usable for absorbing metal cations present in an aqueous or organic solution.
    Type: Grant
    Filed: January 9, 1991
    Date of Patent: April 6, 1993
    Assignees: Centre National de la Recherche Scientifique, Commissariat A L'Energie Atomique
    Inventors: Jacques Simonet, Angely Lysiane, Noelle Simonet, Viviane Questaigne, Veronique Le Berre, Henri Bouas-Laurent, Jean-Pierre Desvergne
  • Patent number: 5194983
    Abstract: An electro-optical component defined by a substrate which is coated in the growth axis direction with a periodic stack of semiconductor layers suitable for defining a superlattice whose quantum wells are fairly strongly coupled together. By applying a control electric field to the superlattice parallel to its growth axis, the optical absorption threshold is varied, and the direction of variation is towards higher energies.
    Type: Grant
    Filed: November 1, 1991
    Date of Patent: March 16, 1993
    Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventor: Paul Voisin
  • Patent number: 5192687
    Abstract: This process makes it possible to prepare a compound of controlled enantiomeric purity, D-P or L-P respectively, from a substrate S consisting of the oxidized form of the corresponding D/L-P racemate or of the said D/L-P racemate, or else of the optical isomer which is the inverse of that which it is wished to prepare. In accordance with this process, the said substrate S, the said D/L-P racemate or the optical isomer inverse of that which it is wished to prepare, respectively, is introduced into an electrochemical reactor together with an oxidoreductase enzyme capable of catalyzing the oxidation of the optical isomer which is the inverse of that which it is wished to prepare; a potential difference is applied between the electrodes in order to perform the nonstereospecific cathodic reduction of the said substrate S until the isomer having the required enantiomeric purity is obtained; and the cosubstrate of the said enzyme is regenerated by anodic oxidation in the said electrochemical reactor.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: March 9, 1993
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Christian Bourdillon, Jacques Moiroux, Jacques P. B. Bonnefoy, Jean-Marc Laval
  • Patent number: 5193104
    Abstract: An X-ray volume analysis method of crystalline defects of a part (11), comprises the steps of positioning the part in the plane situated at equal distance from the focus of an X-ray source and a focusing plane (14); illuminating the part from a punctual X-ray source (10) by a beam of a large spectral width .DELTA..lambda. and of determined angular opening .DELTA..theta., the opening .DELTA..theta. of the beam being fixed by .DELTA..theta..ltoreq..DELTA..lambda./2d.cos.theta., d being the interreticular distance for the considered reticular planes; orienting the part (11) to obtain the diffraction on a chosen family of reticular planes (30); and collecting and analyzing the X-ray beam near the focusing plane or beyond.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: March 9, 1993
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Pierre Bastie, Bernard Hamelin
  • Patent number: 5188967
    Abstract: In vitro diagnosis of malignant cells originating in the digestive tract by placing a biological specimen in contact with a reagent recognizing the gene coding for human villin.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: February 23, 1993
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale
    Inventors: Daniel Louvard, Brigitte Dudouet, Sylvie Robine, Monique Arpin, Eric Pringault, Alphonse Garcia
  • Patent number: 5189055
    Abstract: The present invention relates to phenylpyrrole compounds, pharmaceutical compositions, preparation and to their application as an active principle, especially as a drug having antimitotic activity.
    Type: Grant
    Filed: April 1, 1991
    Date of Patent: February 23, 1993
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Claude Thal, Olivier Boye, Daniel Guenard, Pierre Potier
  • Patent number: 5179109
    Abstract: The invention relates to pharmaceutical compositions for neuroprotection containing arylcyclohexylamines. These compositions comprise an arylcyclohexylamine in accordance with the formulas: ##STR1## in which: R.sup.1 represents ##STR2## with R.sup.4 being a hydrogen atom, a fluorine atom, an iodine atom or a methyl radical, R.sup.2 stands for a hydrogen atom, the radical OH or the radical CH.sub.3 and R.sup.3 stands for hydrogen atom or the radical CH.sub.2 R.sup.5 with R.sup.5 representing H, OH, Cl, Br or CH.sub.3 COO, provided that R.sup.2 and R.sup.3 are not both a hydrogen atom, or an addition salt to a pharmaceutically acceptable acid of said arylcyclohexylamine.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: January 12, 1993
    Assignee: Centre National de La Recherche Scientifique
    Inventors: Jean-Marc Kamenka, Alain Privat, Robert Chicheportiche, Gerard Rondouin
  • Patent number: 5175066
    Abstract: The present invention relates to a rechargeable battery with solid electrolyte.The battery according to the invention comprises a solid polymer electrolyte, an anode composed of a lithium source and a cathode comprising a lithium-receiving material. The lithium-receiving material is a compound of the formula CF.sub.x M.sub.y, where M is chosen from I, Cl, Br, Re, W, Mo, B and 0.3.ltoreq.x.ltoreq.0.9, 0.02.ltoreq.y.ltoreq.0.06, and the structure of this material is such that the carbon atoms form planar hexagons.The battery according to the invention has improved capacity.
    Type: Grant
    Filed: June 25, 1991
    Date of Patent: December 29, 1992
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Andre Hamwi, Rachid Yazami
  • Patent number: 5174930
    Abstract: Dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions are prepared by combining a first liquid phase consisting essentially of a solution of the lipids with a greater amount of a second liquid phase consisting essentially of water. The solvent for the first liquid phase is miscible in all proportions with water. If desired, the first liquid phase may also contain a substance A in solution therewith, such as cholesterol. An additional substance B, which is a biologically active substance, may be present in the first phase if it is lipophilic, and in the second phase if it is hydrophilic.
    Type: Grant
    Filed: March 6, 1991
    Date of Patent: December 29, 1992
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Serge Stainmesse, Hatem Fessi, Jean-Philippe Devissaguet, Francis Puisieux
  • Patent number: 5171926
    Abstract: A bow musical instrument in which at least the front (1) is constituted by a thin wall of composite material comprising at least two superposed sheets (A, B, C, D, . . . ) of crossed and directed long fibers, the wall being covered on at least one of its faces with a lining material (Y, Z) of considerably lower density than the fibers, wherein the deposition of the sheets of fibers is such that the ratio of the longitudinal modulus of elasticity divided by the transverse modulus of elasticity of the wall is higher in a wall zone close to the longitudinal axis of symmetry of the instrument than it is for a zone close to the sides of the instrument.
    Type: Grant
    Filed: February 20, 1991
    Date of Patent: December 15, 1992
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Charles Besnainou, Stephane Vaiedelich
  • Patent number: 5171678
    Abstract: New lipopolyamines of general formula (I), their salts, their preparation and their use. ##STR1## n=1 to 5 and m=2 to 6; R represents a radical ##STR2## (R.sub.1 and R.sub.2 : aliphatic radical containing 12 to 22 carbon atoms; R: hydrogen atom or alkyl radical optionally substituted with phenyl), or a radical ##STR3## (X=CH.sub.2, CO; R.sub.3 and R.sub.4 aliphatic radical containing 11 to 21 carbon atoms), their preparation and their use.The lipopolyamines of general formula (I) are especially useful as vectors for the transfection of eukaryotic cells.
    Type: Grant
    Filed: April 17, 1990
    Date of Patent: December 15, 1992
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-Paul Behr, Jean-Philippe Loeffler
  • Patent number: 5168096
    Abstract: A method for preparing an oriented and textured magnetic compound, comprising the steps of preparing a composition at a temperature such that it comprises crystallites of the compound in the presence of a liquid; subjecting the composition to a magnetic force producing crystallite sedimentation; cooling down the composition in the presence of a magnetic force while applying a suitable temperature gradient for improving the development of a desired texture in the sedimentation area.
    Type: Grant
    Filed: March 21, 1991
    Date of Patent: December 1, 1992
    Assignee: Centre National de la Recherche Scientifique
    Inventor: Robert Tournier
  • Patent number: 5168231
    Abstract: Inhomogeneities in a magnetic field are corrected by means of openings of square or polygonal cross-section in the periphery of the magnet. Permanent magnets required for obtaining the desired correction are lodged in the openings. Thus, the orientation of the permanent magnets can only assume a limited number of values, which simplifies the calculation to determine the positions of the magnets used to correct the inhomogeneity of the magnetic field. It is mainly applicable to the correction of inhomogeneity of the magnetic field of a magnet used in nuclear magnetic resonance imaging.
    Type: Grant
    Filed: May 11, 1990
    Date of Patent: December 1, 1992
    Assignee: Centre National de la Recherche Scientifique
    Inventor: Guy Aubert
  • Patent number: RE34277
    Abstract: Process for preparing taxol by the condensation of a (2R, 3S) acid of general formula (I) with a taxan derivative of general formula (II), followed by the removal of the groups R.sub.2 and R.sub.3 protecting the hydroxy groups .Iadd.and intermediates used therein.Iaddend..
    Type: Grant
    Filed: November 1, 1991
    Date of Patent: June 8, 1993
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-Noel Denis, Andrew E. Greene, Daniel Guenard, Francoise Gueritte-Voegelein