Patents Assigned to National Dong Hwa University
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Patent number: 11920157Abstract: Applications of butylidenephthalide (BP), comprising the use of BP in providing a kit for promoting differentiation of stem cells into brown adipose cells, and the use of BP in preparing a medicament, wherein the medicament is used for inhibiting the accumulation of white adipose cells, promoting the conversion of white adipose cells into brown adipose cells, inhibiting weight gain and/or reducing the content of triglycerides, glucose, and total cholesterol in blood.Type: GrantFiled: September 15, 2022Date of Patent: March 5, 2024Assignee: NATIONAL DONG HWA UNIVERSITYInventors: Tzyy-Wen Chiou, Shinn-Zong Lin, Horng-Jyh Harn, Hong-Lin Su, Shih-Ping Liu, Kang-Yun Lu, Jeanne Hsieh
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Patent number: 11719880Abstract: A perovskite optical element includes a light guiding unit and a luminescent layer. The light guiding unit is configured to conduct light and serves as a resonant cavity. The luminescent layer is a thin film made of perovskite material and clads the light guiding unit. The luminescent layer is configured to be excited by an excitation module to emit light. The light is conducted and output by the light guiding unit. A manufacturing method of a perovskite optical element includes preparing a dip coating solution; dipping a single crystal optical fiber in the dip coating solution for one hour, removing the single crystal optical fiber out of the dip coating solution, and drying the single crystal optical fiber; and placing the single crystal optical fiber into a tube furnace, heating the crystal optical fiber, and introducing synthetic molecules into the tube furnace.Type: GrantFiled: December 10, 2021Date of Patent: August 8, 2023Assignee: NATIONAL DONG HWA UNIVERSITYInventors: Duc-Huy Nguyen, Jia-Yuan Sun, Chia-Yao Lo, Jia-Ming Liu, Wan-Shao Tsai, Ming-Hung Li, Sin-Jhang Yang, Cheng-Chia Lin, Shien-Der Tzeng, Yuan-Ron Ma, Ming-Yi Lin, Chien-Chih Lai
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Publication number: 20220138941Abstract: The invention introduces a method for remotely diagnosing tongues based on deep learning, performed by processing unit, including: obtaining a medical-treatment request and medical-record information containing a shooting photo from a client apparatus over a network; inputting the shooting photo to a plurality of partial-detection convolutional neural networks (CNNs) to obtain a plurality of classification results of a plurality of categories, which are associated with a tongue of the shooting photo; displaying a screen of a remote tongue-diagnosis application on a display unit, which contains the classification results of the categories; obtaining a medical advice corresponding to the classification results of the categories; and replying with the medical advice to the client apparatus over the network.Type: ApplicationFiled: October 26, 2021Publication date: May 5, 2022Applicant: National Dong Hwa UniversityInventors: Shi-Jim YEN, Wen-Chih CHEN, Xian-Dong CHIU, Shi-Cheng YE, Yu-Jin LIN, Chen-Ling LEE
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Publication number: 20220138456Abstract: The invention introduces a method for diagnosing tongues based on deep learning, performed by processing unit of a tablet computer, including: obtaining a shooting photo through a camera module of the tablet computer; inputting the shooting photo to a convolutional neural network (CNN) to obtain classification results of categories, which are associated with a tongue of the shooting photo; and displaying a screen of a tongue-diagnosis application on a display panel of the tablet computer, where the screen includes the classification results of the categories.Type: ApplicationFiled: November 17, 2020Publication date: May 5, 2022Applicant: National Dong Hwa UniversityInventors: Shi-Jim YEN, Wen-Chih CHEN, Xian-Dong CHIU, Shi-Cheng YE, Yu-Jin LIN, Chen-Ling LEE
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Patent number: 11213560Abstract: The present disclosure provides compositions and dosage forms comprising sinetirucallol, and methods of using such compositions, such as to treat an inflammation-associated disease, liver fibrosis, wound healing, and/or an autoimmune disease. In some embodiments, the composition comprises a Spiranthes sinensis extract.Type: GrantFiled: May 28, 2020Date of Patent: January 4, 2022Assignee: NATIONAL DONG HWA UNIVERSITYInventors: Maw-Kuen Wu, Ching-Feng Weng, Huei Wun Sie, Hung Yuan Shih
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Patent number: 10314847Abstract: The present invention discloses scalarane sesterterpenoids represented by formula (I) and meroditerpenoid represented by formula (II), which are extracted from Carteriospongia sp. sponge: where R1 is —CH3 or —C2H5. The compounds of formula (I) can be used to be an anticancer, act as an inhibitor targeting to topoisomerase II and hsp90 and a pharmaceutical composition for anticancer.Type: GrantFiled: August 14, 2017Date of Patent: June 11, 2019Assignee: National Dong Hwa UniversityInventors: Mei-Chin Lu, Ping-Jyun Sung, Jui-Hsin Su, Kuei-Hung Lai, Yi-Chang Liu, Ying-Chi Du, Yu-Ming Hsu, Ming-Kai Weng, Fu-Wen Kuo
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Publication number: 20180271879Abstract: The present invention discloses scalarane sesterterpenoids represented by formula (I) and meroditerpenoid represented by formula (II), which are extracted from Carteriospongia sp. sponge: where R1 is —CH3 or —C2H5. The compounds of formula (I) can be used to be an anticancer, act as an inhibitor targeting to topoisomerase II and hsp90 and a pharmaceutical composition for anticancer.Type: ApplicationFiled: August 14, 2017Publication date: September 27, 2018Applicant: NATIONAL DONG HWA UNIVERSITYInventors: Mei-Chin Lu, Ping-Jyun Sung, Jui-Hsin Su, Kuei-Hung Lai, Yi-Chang Liu, Ying-Chi Du, Yu-Ming Hsu, Ming-Kai Weng, Fu-Wen Kuo
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Patent number: 9855280Abstract: The present application provides a composition comprising a core formed by gold nanoparticle, a compound of Formula (I): wherein dashed lines in Formula (I) represent (i) with or without an attachment of benzol group, (ii) a delocalized bond where shown within a ring; R1 is hydrogen or a halogen; R2 is a linker selected from C6-20 alkyl or polyethylene glycol; R3 is C1-20 alkyl, C1-20 substituted alkyl, hexadecanyl amido, pyridinyl, benzyl or pyrimidinyl; and a compound of Formula (II): wherein dashed lines, R1, R2 and R3 are defined as in Formula (II), and M is a metal. The composition has an inhibition ability against a cancer.Type: GrantFiled: November 4, 2016Date of Patent: January 2, 2018Assignee: NATIONAL DONG HWA UNIVERSITYInventors: Ivan Jyh Biau Lin, Tina H. T. Hsu, Shiu-Huey Chou
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Patent number: 9682063Abstract: The present invention provides a novel formulation for cancer treatment and a method for enhancing the HCD's efficacy in cancer treatment. Specifically, the present invention provides copper-modified silica nanoparticles loaded with HCD, which exhibits better efficacy than some conventional anticancer drugs.Type: GrantFiled: February 25, 2015Date of Patent: June 20, 2017Assignee: National Dong Hwa UniversityInventors: Ching-Feng Weng, Yi-Chen Chia, Chia-Hung Lee, T. Varadharajan
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Publication number: 20170129907Abstract: The present application provides a composition comprising a core formed by gold nanoparticle, a compound of Formula (I): wherein dashed lines in Formula (I) represent (i) with or without an attachment of benzol group, (ii) a delocalized bond where shown within a ring; R1 is hydrogen or a halogen; R2 is a linker selected from C6-20 alkyl or polyethylene glycol; R3 is C1-20 alkyl, C1-20 substituted alkyl, hexadecanyl amido, pyridinyl, benzyl or pyrimidinyl; and a compound of Formula (II): wherein dashed lines, R1, R2 and R3 are defined as in Formula (II), and M is a metal. The composition has an inhibition ability against a cancer.Type: ApplicationFiled: November 4, 2016Publication date: May 11, 2017Applicant: National Dong Hwa UniversityInventors: Ivan Jyh Biau LIN, Tina H. T. HSU, Shiu-Huey CHOU
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Patent number: 9604894Abstract: The present invention relates to a method or composition for treating diabetes mellitus, comprising administering a subject with a pharmaceutical composition comprising a therapeutically effective amount of an active compound from Antrodia camphorate, such as antroquinonols, and a pharmaceutically acceptable carrier. In addition, the prevent invention provides a new process for the total synthesis of antroquinonol. Also provided are the new compounds produced during the process for preparing of antroquinonol.Type: GrantFiled: January 22, 2014Date of Patent: March 28, 2017Assignee: National Dong Hwa UniversityInventors: Ching-Feng Weng, Chin-piao Chen, Sulake Rohidas Shivaji, Chia-Yu Hsu
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Patent number: 9585864Abstract: This invention relates to a pharmaceutical formulation containing z-butylidenephthalide and a polymer, e.g., a polyanhydride. Also disclosed is use of this formulation to treat tumor.Type: GrantFiled: April 14, 2015Date of Patent: March 7, 2017Assignee: National Dong Hwa UniversityInventors: Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin
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Patent number: 9226950Abstract: The present invention relates to a method or composition for glycemic control in a subject, which is effective for treating diabetes mellitus, comprising administering the subject with a pharmaceutical composition comprising a therapeutically effective amount of an aliphatic alcohol having a general formula of CH3(CH2)nCH2OH, wherein n is an integer from 10 to 40, such as tetracosanol, and a pharmaceutically acceptable carrier.Type: GrantFiled: November 12, 2013Date of Patent: January 5, 2016Assignee: National Dong Hwa UniversityInventors: Ching-Feng Weng, Chin-piao Chen, Yi-Chen Chia, Chia-Yu Hsu
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Publication number: 20150203430Abstract: The present invention relates to a method or composition for treating diabetes mellitus, comprising administering a subject with a pharmaceutical composition comprising a therapeutically effective amount of an active compound from Antrodia camphorate, such as antroquinonols, and a pharmaceutically acceptable carrier. In addition, the prevent invention provides a new process for the total synthesis of antroquinonol. Also provided are the new compounds produced during the process for preparing of antroquinonol.Type: ApplicationFiled: January 22, 2014Publication date: July 23, 2015Applicant: National Dong Hwa UniversityInventors: Ching-Feng Weng, Chin-piao Chen, Sulake Rohidas Shivaji, Chia-Yu Hsu
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Publication number: 20150133371Abstract: The present invention relates to a method or composition for glycemic control in a subject, which is effective for treating diabetes mellitus, comprising administering the subject with a pharmaceutical composition comprising a therapeutically effective amount of an aliphatic alcohol having a general formula of CH3(CH2)nCH2OH, wherein n is an integer from 10 to 40, such as tetracosanol, and a pharmaceutically acceptable carrier.Type: ApplicationFiled: November 12, 2013Publication date: May 14, 2015Applicant: National Dong Hwa UniversityInventors: Ching-Feng Weng, Chin-piao Chen, Yi-Chen Chia, Chia-Yu Hsu
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Patent number: 8927601Abstract: Provided is a method for treating a liver injury such as fibrosis, cirrhosis and hepatitis as well as a method for restoring liver function in a subject, which includes administrating to the subject a therapeutically effective amount of n-butylidenephthalide having the formula (I) as an active ingredient, or a pharmaceutically acceptable salt of ester thereof: wherein R is ?CHCH2CH2CH3, and n-butylidenephthalide (I) is E form, Z form or a mixture thereof.Type: GrantFiled: December 20, 2011Date of Patent: January 6, 2015Assignee: National Dong Hwa UniversityInventors: Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin
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Publication number: 20140273047Abstract: A method of detecting Mycobacterium tuberculosis complex (MTBC) in a culture media is provided, in which, the culture media containing the MTBC and a biomarker, such as CFP-10, secreted from the MTBC is provided, the culture media is filtered to obtain a filtrate, detonation nanodiamond particles are mixed with the filtrate to form biomarker-loaded detonation nanodiamond particles, and a mass spectrometry analysis process is performed on the biomarker-loaded detonation nanodiamond particles for detecting the biomarker.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: NATIONAL DONG HWA UNIVERSITYInventors: Wen-Ping Peng, Po-Chi Soo, Ching-Jen Kung, Kou-Hwa Chang, Shu-Chuan Yu, Wan-Zo Ho
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Publication number: 20130311141Abstract: A signal denoising method for a frequency-scan ion trap mass spectrometer includes reading a signal raw data array observed in the spectrometer. The signal raw data array is processed by Boxcar averaging method to obtain a first signal array. Then the first signal array is processed by a harmonic interference cancellation method to obtain a second data array. Next the second signal array is processed by a radio frequency interference reduction method and a third signal array without the background induced from driving voltage of ion trap is reconstructed according to the second signal array.Type: ApplicationFiled: May 20, 2013Publication date: November 21, 2013Applicant: National Dong Hwa UniversityInventors: Wen-Ping Peng, Szu-Wei Chou, Hsin-Min Shen, Kou-Hwa Chang
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Publication number: 20130158108Abstract: Provided is a method for treating a liver injury such as fibrosis, cirrhosis and hepatitis as well as a method for restoring liver function in a subject, which includes administrating to the subject a therapeutically effective amount of n-butylidenephthalide having the formula (I) as an active ingredient, or a pharmaceutically acceptable salt of ester thereof: wherein R is ?CHCH2CH2CH3, and n-butylidenephthalide (I) is E form, Z form or a mixture thereof.Type: ApplicationFiled: December 20, 2011Publication date: June 20, 2013Applicant: National Dong Hwa UniversityInventors: Tzyy-Wen CHIOU, Horng-Jyh Harn, Shinn-Zong Lin
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Patent number: 8368260Abstract: An instantaneous magnetodynamic generator includes a magnetic plate and a first metallic electrode plate. The magnetic plate has at least one pair of N and S magnetic poles. One magnetic pole of the pair of N and S magnetic poles has a first magnetic pole face, and the other magnetic pole of the pair of N and S magnetic poles has a second magnetic pole face. The first metallic electrode plate has an electrode face and at least one metallic wire. The electrode face faces the first and second magnetic pole faces. The metallic wire has a free end moving between a position beneath the first magnetic pole face and a position beneath the second magnetic pole face to induce a positive or negative tunneling current on the first metallic electrode plate.Type: GrantFiled: October 28, 2010Date of Patent: February 5, 2013Assignee: National Dong Hwa UniversityInventor: Yuan-Ron Ma