Patents Assigned to National Dong Hwa University
  • Publication number: 20220138941
    Abstract: The invention introduces a method for remotely diagnosing tongues based on deep learning, performed by processing unit, including: obtaining a medical-treatment request and medical-record information containing a shooting photo from a client apparatus over a network; inputting the shooting photo to a plurality of partial-detection convolutional neural networks (CNNs) to obtain a plurality of classification results of a plurality of categories, which are associated with a tongue of the shooting photo; displaying a screen of a remote tongue-diagnosis application on a display unit, which contains the classification results of the categories; obtaining a medical advice corresponding to the classification results of the categories; and replying with the medical advice to the client apparatus over the network.
    Type: Application
    Filed: October 26, 2021
    Publication date: May 5, 2022
    Applicant: National Dong Hwa University
    Inventors: Shi-Jim YEN, Wen-Chih CHEN, Xian-Dong CHIU, Shi-Cheng YE, Yu-Jin LIN, Chen-Ling LEE
  • Publication number: 20220138456
    Abstract: The invention introduces a method for diagnosing tongues based on deep learning, performed by processing unit of a tablet computer, including: obtaining a shooting photo through a camera module of the tablet computer; inputting the shooting photo to a convolutional neural network (CNN) to obtain classification results of categories, which are associated with a tongue of the shooting photo; and displaying a screen of a tongue-diagnosis application on a display panel of the tablet computer, where the screen includes the classification results of the categories.
    Type: Application
    Filed: November 17, 2020
    Publication date: May 5, 2022
    Applicant: National Dong Hwa University
    Inventors: Shi-Jim YEN, Wen-Chih CHEN, Xian-Dong CHIU, Shi-Cheng YE, Yu-Jin LIN, Chen-Ling LEE
  • Patent number: 10314847
    Abstract: The present invention discloses scalarane sesterterpenoids represented by formula (I) and meroditerpenoid represented by formula (II), which are extracted from Carteriospongia sp. sponge: where R1 is —CH3 or —C2H5. The compounds of formula (I) can be used to be an anticancer, act as an inhibitor targeting to topoisomerase II and hsp90 and a pharmaceutical composition for anticancer.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: June 11, 2019
    Assignee: National Dong Hwa University
    Inventors: Mei-Chin Lu, Ping-Jyun Sung, Jui-Hsin Su, Kuei-Hung Lai, Yi-Chang Liu, Ying-Chi Du, Yu-Ming Hsu, Ming-Kai Weng, Fu-Wen Kuo
  • Patent number: 9682063
    Abstract: The present invention provides a novel formulation for cancer treatment and a method for enhancing the HCD's efficacy in cancer treatment. Specifically, the present invention provides copper-modified silica nanoparticles loaded with HCD, which exhibits better efficacy than some conventional anticancer drugs.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: June 20, 2017
    Assignee: National Dong Hwa University
    Inventors: Ching-Feng Weng, Yi-Chen Chia, Chia-Hung Lee, T. Varadharajan
  • Publication number: 20170129907
    Abstract: The present application provides a composition comprising a core formed by gold nanoparticle, a compound of Formula (I): wherein dashed lines in Formula (I) represent (i) with or without an attachment of benzol group, (ii) a delocalized bond where shown within a ring; R1 is hydrogen or a halogen; R2 is a linker selected from C6-20 alkyl or polyethylene glycol; R3 is C1-20 alkyl, C1-20 substituted alkyl, hexadecanyl amido, pyridinyl, benzyl or pyrimidinyl; and a compound of Formula (II): wherein dashed lines, R1, R2 and R3 are defined as in Formula (II), and M is a metal. The composition has an inhibition ability against a cancer.
    Type: Application
    Filed: November 4, 2016
    Publication date: May 11, 2017
    Applicant: National Dong Hwa University
    Inventors: Ivan Jyh Biau LIN, Tina H. T. HSU, Shiu-Huey CHOU
  • Patent number: 9604894
    Abstract: The present invention relates to a method or composition for treating diabetes mellitus, comprising administering a subject with a pharmaceutical composition comprising a therapeutically effective amount of an active compound from Antrodia camphorate, such as antroquinonols, and a pharmaceutically acceptable carrier. In addition, the prevent invention provides a new process for the total synthesis of antroquinonol. Also provided are the new compounds produced during the process for preparing of antroquinonol.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: March 28, 2017
    Assignee: National Dong Hwa University
    Inventors: Ching-Feng Weng, Chin-piao Chen, Sulake Rohidas Shivaji, Chia-Yu Hsu
  • Patent number: 9585864
    Abstract: This invention relates to a pharmaceutical formulation containing z-butylidenephthalide and a polymer, e.g., a polyanhydride. Also disclosed is use of this formulation to treat tumor.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: March 7, 2017
    Assignee: National Dong Hwa University
    Inventors: Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin
  • Patent number: 9226950
    Abstract: The present invention relates to a method or composition for glycemic control in a subject, which is effective for treating diabetes mellitus, comprising administering the subject with a pharmaceutical composition comprising a therapeutically effective amount of an aliphatic alcohol having a general formula of CH3(CH2)nCH2OH, wherein n is an integer from 10 to 40, such as tetracosanol, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: January 5, 2016
    Assignee: National Dong Hwa University
    Inventors: Ching-Feng Weng, Chin-piao Chen, Yi-Chen Chia, Chia-Yu Hsu
  • Publication number: 20150203430
    Abstract: The present invention relates to a method or composition for treating diabetes mellitus, comprising administering a subject with a pharmaceutical composition comprising a therapeutically effective amount of an active compound from Antrodia camphorate, such as antroquinonols, and a pharmaceutically acceptable carrier. In addition, the prevent invention provides a new process for the total synthesis of antroquinonol. Also provided are the new compounds produced during the process for preparing of antroquinonol.
    Type: Application
    Filed: January 22, 2014
    Publication date: July 23, 2015
    Applicant: National Dong Hwa University
    Inventors: Ching-Feng Weng, Chin-piao Chen, Sulake Rohidas Shivaji, Chia-Yu Hsu
  • Publication number: 20150133371
    Abstract: The present invention relates to a method or composition for glycemic control in a subject, which is effective for treating diabetes mellitus, comprising administering the subject with a pharmaceutical composition comprising a therapeutically effective amount of an aliphatic alcohol having a general formula of CH3(CH2)nCH2OH, wherein n is an integer from 10 to 40, such as tetracosanol, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 14, 2015
    Applicant: National Dong Hwa University
    Inventors: Ching-Feng Weng, Chin-piao Chen, Yi-Chen Chia, Chia-Yu Hsu
  • Patent number: 8927601
    Abstract: Provided is a method for treating a liver injury such as fibrosis, cirrhosis and hepatitis as well as a method for restoring liver function in a subject, which includes administrating to the subject a therapeutically effective amount of n-butylidenephthalide having the formula (I) as an active ingredient, or a pharmaceutically acceptable salt of ester thereof: wherein R is ?CHCH2CH2CH3, and n-butylidenephthalide (I) is E form, Z form or a mixture thereof.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: January 6, 2015
    Assignee: National Dong Hwa University
    Inventors: Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin
  • Publication number: 20130311141
    Abstract: A signal denoising method for a frequency-scan ion trap mass spectrometer includes reading a signal raw data array observed in the spectrometer. The signal raw data array is processed by Boxcar averaging method to obtain a first signal array. Then the first signal array is processed by a harmonic interference cancellation method to obtain a second data array. Next the second signal array is processed by a radio frequency interference reduction method and a third signal array without the background induced from driving voltage of ion trap is reconstructed according to the second signal array.
    Type: Application
    Filed: May 20, 2013
    Publication date: November 21, 2013
    Applicant: National Dong Hwa University
    Inventors: Wen-Ping Peng, Szu-Wei Chou, Hsin-Min Shen, Kou-Hwa Chang
  • Publication number: 20130158108
    Abstract: Provided is a method for treating a liver injury such as fibrosis, cirrhosis and hepatitis as well as a method for restoring liver function in a subject, which includes administrating to the subject a therapeutically effective amount of n-butylidenephthalide having the formula (I) as an active ingredient, or a pharmaceutically acceptable salt of ester thereof: wherein R is ?CHCH2CH2CH3, and n-butylidenephthalide (I) is E form, Z form or a mixture thereof.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 20, 2013
    Applicant: National Dong Hwa University
    Inventors: Tzyy-Wen CHIOU, Horng-Jyh Harn, Shinn-Zong Lin
  • Patent number: 8368260
    Abstract: An instantaneous magnetodynamic generator includes a magnetic plate and a first metallic electrode plate. The magnetic plate has at least one pair of N and S magnetic poles. One magnetic pole of the pair of N and S magnetic poles has a first magnetic pole face, and the other magnetic pole of the pair of N and S magnetic poles has a second magnetic pole face. The first metallic electrode plate has an electrode face and at least one metallic wire. The electrode face faces the first and second magnetic pole faces. The metallic wire has a free end moving between a position beneath the first magnetic pole face and a position beneath the second magnetic pole face to induce a positive or negative tunneling current on the first metallic electrode plate.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: February 5, 2013
    Assignee: National Dong Hwa University
    Inventor: Yuan-Ron Ma
  • Publication number: 20110165201
    Abstract: This invention relates to a pharmaceutical formulation containing z-butylidenephthalide and a polymer, e.g., a polyanhydride. Also disclosed is use of this formulation to treat tumor.
    Type: Application
    Filed: January 4, 2011
    Publication date: July 7, 2011
    Applicant: National Dong Hwa University
    Inventors: Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin