Abstract: A method for synthesizing a nanohybrid comprising forming a polymer solution by dissolving carboxymethyl chitosan and gelatin in a 2-(N-Morpholino)ethanesulfonic acid (MES) buffer, forming a first solution by adding (3-Glycidyloxypropyl)trimethoxysilane (GPTMS) to the polymer solution, forming a second solution by adding an acid-hydrolyzed tetraethyl orthosilicate (TEOS) solution to the first solution, forming a third solution by adding a calcium chloride (CaCl2) solution to the second solution, forming a fourth solution by mixing the third solution with a solution of 1 ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS), forming a frozen nanohybrid, and thawing the frozen nanohybrid.