Abstract: The present application provides a method for preparing a probiotic-loaded microcapsule including: (1) dissolving sodium alginate in a solvent to obtain a sodium alginate solution; (2) evenly mixing a probiotic with the sodium alginate solution obtained in step (1) to obtain a probiotic suspension; and (3) spraying the probiotic suspension obtained in step (2) into a salt solution, stirring and curing, to obtain the probiotic-loaded microcapsule. The microcapsule is prepared by a spraying method in conjunction with an ion curing method by using sodium alginate as the wall material of the microcapsule, so that the prepared microcapsule has a good spherical shape, a small particle size, good dispersibility and high pH sensitivity, forms a denser surface under an acidic condition to effectively protect probiotics, and can meet requirements for subsequent in vivo animal evaluations.
Type:
Application
Filed:
August 18, 2020
Publication date:
May 12, 2022
Applicants:
National Institute for Nutrition and Health Chinese Center for Disease Control and Prevention, Institute of Process Engineering, Chinese Academy of Sciences
Inventors:
Gangqiang Ding, Junsheng Huo, Lianyan Wang, Jian Huang, Guifeng Zhang, Yanbin Tang, Ke Cao, Yingbin Cui, Zheng Cao