Abstract: The present invention relates to a method for producing Cypridina luciferase labeled with hydrophilic biotin, characterized in that a biotin reagent containing a polyalkylene glycol structure as a spacer is reacted with Cypridina luciferase, and biotin-labeled Cypridina luciferase wherein a sugar chain in Cypridina luciferase has been biotinylated.

Abstract: The present invention provides a method for designing DNA code consisting of a set of information codes as an information carrier to write optional information into an optional noncoding region not including any DNA genetic information which can avoid an error occurring when the designed DNA is used. A set S1 of the base sequences corresponding to a signal unit for information transmission is obtained as follows: 1) selecting a template such that its Hamming distance of templates, against its block shift, and against the ligated sequences are equal to or above the predetermined value, when DNA sequence of predetermined length is specified by the binary string of 0 and 1 (template), meaning that the position of G or C ([GC]), or A or T ([AT]) are fixed, 2) further selecting a template having a subword constraint of length m from the set of the selected templates, and 3) combining thus selected template and codewords of the predetermined error-correcting codes having a subword constraint of length m.