Patents Assigned to National Institute of Health (NIH)
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Patent number: 9809797Abstract: A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described.Type: GrantFiled: September 25, 2008Date of Patent: November 7, 2017Assignee: NATIONAL INSTITUTES OF HEALTH (NIH) U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS) DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGYInventors: Cassian Yee, Yongqing Li
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Patent number: 9770186Abstract: Methods and apparatus for operating an MRI system is provided. The disclosure provides a diffusion-prepared driven-equilibrium preparation for an imaging volume and acquiring 3-dimensional k-space data from said prepared volume by a plurality of echoplanar readouts of stimulated echoes. An excitation radio-frequency signal and first and second inversion RF signals are provided to define a field-of-view (FOV).Type: GrantFiled: February 19, 2013Date of Patent: September 26, 2017Assignee: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Eun-Kee Jeong, Dennis L Parker, Kim Seong-Eun Choi, Evgueni G Kholmovski
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Patent number: 9737478Abstract: The invention contemplates compositions for the treatment of malaria comprising an anti-malaria drug and an adjuvant which promotes vasodilation and methods of using same.Type: GrantFiled: September 13, 2010Date of Patent: August 22, 2017Assignee: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Leonardo Jose de Moura Carvalho, Pedro Cabrales
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Patent number: 9707289Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.Type: GrantFiled: April 8, 2011Date of Patent: July 18, 2017Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, NATIONAL INSTITUTES OF HEALTH (NIH), THE UNITED STATES OF AMERICA DEPT. OF HEALTH AND HUMAN SERVICES (DHHS).Inventors: Stephen C. Harrison, Bing Chen, Dan C. Barouch, Joseph P. Nkolola, Michael Scott Seaman
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Patent number: 9687172Abstract: A system determines motion correction data for use in diffusion MR imaging using an RF signal generator and magnetic field gradient generator which sequentially acquire in a single first direction through a volume, first and second slice sets individually comprising multiple individual diffusion image slices. The first set of slices and the second set of slices are spatially interleaved within the volume, by providing in acquiring the second slice set, a low flip angle RF pulse successively followed by a non-diffusion image data readout magnetic field gradient for acquisition of data representing a two dimensional (2D) non-diffusion image used for motion detection of the first slice set successively followed by, a first diffusion imaging RF pulse followed by a first diffusion imaging phase encoding magnetic field gradient for preparation for acquiring data representing a diffusion image slice of the second slice set.Type: GrantFiled: June 20, 2012Date of Patent: June 27, 2017Assignees: National Institute of Health (NIH), The United States of America, U.S. Dept. of Health and Human Services (DHHS), Siemens Healthcare GmbHInventors: Himanshu Bhat, Andre Jan Willem Van Der Kouwe, Matthew Dylan Tisdall, Keith Aaron Heberlein
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Patent number: 9649343Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.Type: GrantFiled: September 9, 2016Date of Patent: May 16, 2017Assignee: National Institutes of Health (NIH); U.S. Department of Health and Human Services (DHHS); The United States of America, NIH Division of Extramural Inventions and Tehnology Resources (DEITR)Inventors: Michael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton
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Patent number: 9594141Abstract: An MR imaging system uses multiple RF coils for acquiring corresponding multiple image data sets of a slice or volume of patient anatomy. An image data processor comprises at least one processing device conditioned for, deriving a first set of weights for weighted combination of k-space data of the multiple image data sets for generating a calibration data set comprising a subset of k-space data of composite image data representing the multiple image data sets. The image data processor uses the calibration data set in generating a first MR image data set, deriving the parameters of a probability distribution in response to the first set of weights and the first MR image data set and deriving a second set of weights and second MR image data set together using the probability distribution.Type: GrantFiled: October 3, 2012Date of Patent: March 14, 2017Assignees: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR), The General Hospital Corporation, Siemens Healthcare GmbHInventors: Daniel Weller, Leo Grady, Lawrence Wald, Vivek K Goyal
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Patent number: 9588207Abstract: A system for parallel image processing in MR imaging comprises multiple MR imaging RF coils for individually receiving MR imaging data representing a slice of patient anatomy. An MR imaging system uses the multiple RF coils for acquiring corresponding multiple image data sets of the slice. An image data processor comprises at least one processing device conditioned for, deriving a first set of weights for generating a calibration data set comprising a subset of k-space data of composite image data representing the multiple image data sets. The at least one processing device uses the calibration data set in generating a first MR image data set, deriving a second set of weights using the calibration data set and the generated first MR image data set and uses the second set of weights in generating a second MR image data set representing a single image having a reduced set of data components relative to the first composite MR image data set.Type: GrantFiled: September 14, 2012Date of Patent: March 7, 2017Assignees: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR), Siemens Healthcare GmbHInventors: Daniel Weller, Leo Grady, Lawrence Wald, Vivek K Goyal
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Patent number: 9588208Abstract: A method for accelerated segmented magnetic resonance (MR) image data acquisition includes using a plurality of RF pulses to excite one or more slices of an anatomical area of interest according to a predetermined slice acceleration factor. Next, a collapsed image comprising the slices is acquired using a consecutive segment acquisition process. Then, a parallel image reconstruction method is applied to the collapsed image to separate the collapsed image into a plurality of slice images.Type: GrantFiled: May 7, 2014Date of Patent: March 7, 2017Assignees: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), U.S. Government NIH Division of Extramural Inventions and Technology Resources (DEITR), Siemens Healthcare GmbHInventors: Jonathan Rizzo Polimeni, Himanshu Bhat, Keith Aaron Heberlein, Kawin Setsompop, Thomas Witzel, Stephen Farman Cauley
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Patent number: 9439978Abstract: Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.Type: GrantFiled: September 28, 2012Date of Patent: September 13, 2016Assignees: University of South Florida, The United States of America as represented by National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), U.S. GovernmentInventors: Subhra Mohapatra, Chunyan Wang
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Patent number: 9433682Abstract: Provided herein is a hydrogel composition comprising a graphene, a chitosan, and a polyethylene (glycol) diacrylate (PEGDA) (PCG hydrogel). In some embodiments, the hydrogel further comprises a N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided is a method for differentiating a mesenchymal stem cell comprising contacting the cell with the PCG hydrogel. Further provided herein is a method for delivering a pharmaceutical composition to a cell comprising administering to the cell a TPCG hydrogel and the pharmaceutical composition.Type: GrantFiled: February 25, 2013Date of Patent: September 6, 2016Assignees: University South Florida, National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)Inventors: Subhra Mohapatra, Chunyan Wang
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Patent number: 9399660Abstract: N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof.Type: GrantFiled: April 28, 2015Date of Patent: July 26, 2016Assignees: Purdue Research Foundation, NATIONAL INSTITUTES OF HEALTH (NIH)Inventors: Mark S. Cushman, Yves George Pommier, Peng-Cheng Lu, Christophe Marchand, Keli Agama
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Patent number: 9388211Abstract: N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof.Type: GrantFiled: April 15, 2015Date of Patent: July 12, 2016Assignees: Purdue Research Foundation, NATIONAL INSTITUTES OF HEALTH (NIH)Inventors: Mark S. Cushman, Andrew E. Morrell, Muthukaman Nagarajan, Yves George Pommier, Smitha Antony, Keli K. Agama, Daniel E. Beck
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Patent number: 9360539Abstract: A system for perfusion and diffusion MR imaging of a portion of patient anatomy includes an RF (Radio Frequency) signal generator for generating RF excitation pulses in anatomy and enabling subsequent acquisition of associated RF echo data. A magnetic field gradient generator generates anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition in a three dimensional (3D) anatomical volume. The RF signal generator and the gradient generator acquire within a single MR imaging scan, perfusion image data of the 3D volume, at least partially in the presence of contrast agent, and diffusion image data of the 3D volume.Type: GrantFiled: December 12, 2012Date of Patent: June 7, 2016Assignee: National Institute of Health (NIH), U.S. Dept. Of Health and Human Services (DHHS), U.S. GovernmentInventors: Timothy J Carroll, Yong Jeong, Sumeeth Vijay Jonathan, Parmede Vakil
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Patent number: 9333237Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.Type: GrantFiled: April 28, 2014Date of Patent: May 10, 2016Assignees: The United States of America National Institutes of Health (NIH), U.S. Dept of Health and Human Services (DHHS), The Regents of the University of CaliforniaInventors: Samuel S. Murray, Elsa J. Murray, Keyvan Behnam
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Patent number: 9220706Abstract: A method of inhibiting the growth of leukemic hematopoietic stem cells in a subject with leukemia is described. The method includes administering a therapeutically effective amount of a composition including a compound of formula I: I wherein R1 is independently selected from hydrogen and methyl; R2 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, 4,8-dimethyl-nonyl, non-1-enyl, and nonanyl groups; X is a carboxyl, phosphonic, or sulfonic moiety, and n is an integer from 1 to 6, or a compound of Formula II: II wherein R1 is a C6-C12 alkyl or C6-C12 alkoxy group; R2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; and R3 is an alkyl or cycloalkyl group; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 31, 2013Date of Patent: December 29, 2015Assignees: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), THE UNITED STATES OF AMERICA NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR)Inventors: Danilo Perrotti, Paolo Neviani
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Patent number: 9115094Abstract: Substituted 1,4,7-triazacyclononane-N,N?,N?-triacetic acid and 1,4,7,10-tetraazacyclcododecane-N,N?,N?,N??-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.Type: GrantFiled: August 20, 2010Date of Patent: August 25, 2015Assignee: THE UNITED STATES OF AMERICA, NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS)Inventor: Hyun-soon Chong
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Patent number: 9057094Abstract: A method of testing bacterial cells for antimicrobial susceptibility includes preparing a suspension of the bacterial cells in a non-nutrient medium, mixing with the suspension an antimicrobial, a carbohydrate usable by the bacterial cells, metallic nanoparticles, and a lectin, and incubating the mixture while monitoring a parameter of the nanoparticles responsive to use of the carbohydrate by the bacterial cells. More broadly stated, the invention includes a method of testing an agent for its effect on cell metabolism by preparing a suspension of cells in a non-nutrient medium, mixing the suspension with the agent, adding a carbohydrate usable by the cells, metallic nanoparticles, and a lectin with binding specificity for the added carbohydrate, and monitoring a nanoparticle parameter responsive to the cells.Type: GrantFiled: October 27, 2008Date of Patent: June 16, 2015Assignees: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC., NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHSInventors: J. Manuel Perez, Charalambos Kaittanis, Sudip Nath
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Patent number: 9039621Abstract: Disclosed are various embodiments for echoperiodontal imaging. In one embodiment, a system includes a transducer configured to transmit a series of ultrasonic signals at a plurality of corresponding locations along soft tissue of a jaw and receive a plurality of echo signals; and an imaging system controller configured to obtain a plurality of echo signal data of the soft tissue and a plurality of transducer positions, where each echo signal data corresponds to one of the plurality of transducer position.Type: GrantFiled: July 27, 2012Date of Patent: May 26, 2015Assignee: THE UNITED STATES OF AMERICA NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR)Inventors: Osama M. Mukdadi, Ahmed M. Mahmoud, Eros S. Chaves, Richard Crout
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Patent number: 9034870Abstract: The invention described herein pertains to substituted azaindenoisoquinoline compounds, in particular 7-, 8-, 9-, and 10-azaindenoisoquinoline compounds, which are inhibitors of topoisomerase I, processes and intermediates for their syntheses, pharmaceutical compositions of the compounds, and methods of using them in the treatment of cancer.Type: GrantFiled: March 6, 2014Date of Patent: May 19, 2015Assignees: Purdue Research Foundation, United States Government National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Mark S. Cushman, Evgeny A. Kiselev, Andrew E. Morrell, Yves George Pommier