Abstract: Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence to ? agonists.
Type:
Application
Filed:
March 19, 2009
Publication date:
September 24, 2009
Applicants:
Southern Research Institute, National Institute on Drug Abuse, National Institute of Health, University of New England College of Osteopathic Medicine, The Arizona Board of Reagents on behalf of the University of Arizona
Inventors:
Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca