Abstract: The present invention relates to a cocrystal of progesterone, which is formed by the active ingredient progesterone and a cocrystal former which is selected from isophthalic acid, 4-formylbenzeneboronic acid and 3-nitrophthalic acid. The present invention also relates to the method for preparing the cocrystal of progesterone and use thereof for increasing the thickness of endometrium, improving progesterone's solubility or increasing progesterone's permeation rate.
March 4, 2021
Date of Patent:
January 9, 2024
NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL
Lan He, Jing Xiong, Xiangxiang Wu, Xin Zhu, Zhonglin Lu, Yan Shi, Na Zhang, Yang Liu
Abstract: The present disclosure provides a method for constructing a correlation model between relative bioavailability and bioaccessibility of cadmium in earthworm, belonging to the technical field of cadmium detection in earthworms. The method includes the following steps: determination of relative bioavailability of cadmium in earthworms, determination of bioaccessibility of cadmium in the earthworm based on an in vitro physiologically-based extraction test (PBET) method, and construction of a correlation model between the relative bioavailability and the bioaccessibility of cadmium in the earthworm. The method enables to directly put the bioaccessibility obtained by the in vitro method into a regression equation to obtain the bioavailability of cadmium in subsequent studies.
May 27, 2022
August 17, 2023
National Institutes for Food and Drug Control, Wang Jing Hospital of CACMS (Orthopedics Research Institute of CACMS), Tongliao Market Inspection and Testing Center
Abstract: A dianthrone compound may be used in preparation of a medicament for prevention and/or treatment of myocardial ischemic diseases and related diseases thereof. The dianthrone compound includes trans-emodin dianthrone and/or cis-emodin dianthrone.
September 13, 2022
March 23, 2023
National Institutes for Food and Drug Control, Institute of Materia Medica Chinese Academy of Medical Sciences