Patents Assigned to National Institutes of Health (NIH) U.S. Department of Health and Human Services (DHHS), U.S. Government NIH Division of Extramural Inventions and Technology Resources (DEITR)
  • Sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry
    Patent number: 10121645
    Abstract: Provided herein are capillaries for use in an electrophoretic separations. The capillaries can comprise an elongated tubular wall defining a path for fluid flow from an inlet to a tapered outlet; and a decoupler junction positioned within the elongated tubular wall upstream of the tapered outlet. The decoupler junction can comprise a plurality of microchannels penetrating through the elongated tubular wall and an ion-permeable polymer coating the plurality of microchannels. Also provided are sheathless interfaces for coupling capillary electrophoresis (CE) with mass spectrometry that employ these capillaries.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: November 6, 2018
    Assignee: National Institutes of Health (NIH) U.S. Department of Health and Human Services (DHHS), U.S. Government NIH Division of Extramural Inventions and Technology Resources (DEITR)
    Inventors: Craig E. Lunte, Ryan Tyler Johnson, Nhan To, Susan M. Lunte, Damon Osbourn