Patents Assigned to National Institutes of Health (NIH)
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Publication number: 20150133390Abstract: Methods for identifying new therapeutic activities for known therapeutic agents, as well as systems for practicing the same, are provided. Aspects of the invention further include are methods and compositions for the treatment of an acute graft rejection (AR).Type: ApplicationFiled: January 25, 2013Publication date: May 14, 2015Applicant: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), U.S. Govt.Inventors: Purvesh Khatri, Atul J. Butte, Minnie M. Sarwal
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Patent number: 8999322Abstract: Novel thrombin/prothrombin protease/zymogen variants which have anticoagulation activity and methods of use thereof are disclosed.Type: GrantFiled: December 10, 2012Date of Patent: April 7, 2015Assignee: The United States of America National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Sriram Krishnaswamy, Elsa P. Bianchini, Steven Orcutt
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Patent number: 8992858Abstract: A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a junction. Based upon an identity of the entity determined in the detection region, a waste or collection valve located on opposite branches of the flow channel at the junction are actuated, thereby routing the entity to either a waste pool or a collection pool. A damper structure may be located between the pump and the junction. The damper reduces the amplitude of oscillation pressure in the flow channel due to operation of the pump, thereby lessening oscillation in velocity of the entity during sorting process. The microfluidic device may be formed in a block of elastomer material, with thin membranes of the elastomer material deflectable into the flow channel to provide pump or valve functionality.Type: GrantFiled: August 21, 2007Date of Patent: March 31, 2015Assignee: The United States of America National Institute of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)Inventors: Hou-Pu Chou, Anne Y. Fu, Stephen R. Quake
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Patent number: 8940690Abstract: The present disclosure provides a cross-linked material comprising conjugates which include two or more separate affinity ligands bound to a non-polymeric framework, wherein the molecular weight of the non-polymeric framework is less than 10,000 Da; and multivalent cross-linking agents that non-covalently bind the affinity ligands of the conjugates and thereby cross-link the conjugates to form a cross-linked material, wherein the non-covalent bonds between the multivalent cross-linking agents and the affinity ligands are competitively dissociated in the presence of excess amounts of a target molecule. The present disclosure also provides methods of making and methods of using these materials. In other aspects, the present disclosure provides exemplary conjugates including conjugates for use in glucose responsive cross-linked materials.Type: GrantFiled: January 27, 2010Date of Patent: January 27, 2015Assignees: National Institutes of Health (NIH), The United States of America Dept. of Health and Human Services (DHHS), The United States of America as represented by NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Todd C. Zion, Thomas M. Lancaster
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Patent number: 8911739Abstract: A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term administration of non-specific immunosuppressive drugs.Type: GrantFiled: February 9, 2010Date of Patent: December 16, 2014Assignees: Trustees of Columbia University in the City of New York, The National Institutes of Health (NIH)Inventors: Hong Jiang, Leonard Chess
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Patent number: 8912159Abstract: Methods, assays, and kits for determining a cancer's (e.g., breast cancer) metastatic potential and tumor aggressiveness in a subject (e.g., a human patient) and for measuring a subject's response to cancer therapy involve analyzing expression of Sema7A in a biological sample from the subject, and correlating increased expression of Sema7A in the biological sample compared to a control sample with metastatic potential of the cancer, wherein the expression of Sema7A is linearly proportional to the metastatic potential of the cancer in the subject. These methods, kits and assays provide for individualized diagnosis and treatment options for cancer (e.g., breast cancer) patients. They can be used independently, or can be combined with additional diagnostic tests and/or prognostic methods. Compositions, kits and methods for treating a subject having cancer (e.g., breast cancer) include administering a composition for inhibiting Sema7A expression or activity to the subject.Type: GrantFiled: February 25, 2013Date of Patent: December 16, 2014Assignees: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Vijaya Iragavarapu-Charyulu, Ramon Garcia-Areas, Stephania Libreros
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Patent number: 8877183Abstract: Methods and therapeutic treatments of ocular diseases are provided including applying peg-Arginase I to affected eyes. Methods are provided that simultaneously treat inflammation and neovascularization of eyes while promoting healing. Methods are provided to treat lesions or infections of an eye.Type: GrantFiled: March 14, 2013Date of Patent: November 4, 2014Assignees: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Timothy Paul Foster, Paulo Cesar Rodriguez, James Milton Hill, Augusto Ochoa
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Patent number: 8865216Abstract: Surface-modified polymeric nanoparticles (NPs), compositions for making them, and their use in drug delivery are disclosed.Type: GrantFiled: August 1, 2008Date of Patent: October 21, 2014Assignees: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)Inventors: Vinod Labhasetwar, Jaspreet Vasir
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Patent number: 8865411Abstract: Compositions and methods are disclosed for identifying agents useful for the treatment of proteinopathies.Type: GrantFiled: March 26, 2010Date of Patent: October 21, 2014Assignees: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Aaron D. Gitler, Andrew Elden
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Patent number: 8838204Abstract: A system and method is provided for magnetic resonance angiography (MRA) that includes performing a pulse sequence using the MRI system, the pulse sequence including a phase-based flow encoding to collect a time-series of image data from the portion of the vasculature of the subject and identifying at least a portion of the time series of image data corresponding to a period of reduced flow through the portion of the vasculature. The portion of the time series of image data is subtracted from the time series of image data to create a time series of images of the portion of the vasculature having background tissue surrounding the portion of the vasculature substantially suppressed.Type: GrantFiled: December 18, 2012Date of Patent: September 16, 2014Assignees: Siemens Medical Solutions USA, Inc., The United States of America as represented by the National Institutes of Health (NIH), U.S. Dept of Health and Human Services (DHHS)Inventors: Robert R Edelman, Christopher Glielmi, Ioannis Koktzoglou, Erik J Offerman
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Patent number: 8779001Abstract: Small molecule inhibitors of Stat3 and their derivatives are disclosed. Also described are methods to inhibit cell growth by use of Stat3 inhibitors, and the use of Stat3 inhibitors for the prevention and/or treatment of cancer. Further, inhibitors of Stat3 that also do not inhibit Stat1 are described as well as their derivatives. Methods of screening additional compounds for Stat3 inhibition activity and/or non-inhibition of Stat1 activity are also described herein.Type: GrantFiled: June 3, 2009Date of Patent: July 15, 2014Assignees: The United States of America National Institute of Health (NIH), The United States of America Dept. of Health and Human Services (DHHS)Inventors: David J. Tweardy, Xuejun Xu, Moses M. Kasembeli
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Patent number: 8752071Abstract: A solution for managing messaging is provided in which an event related to a publisher is identified. In response to the event, a transaction is initiated for processing the event, the event is processed within the transaction, and the transaction is committed after the event is processed. During processing, data corresponding to the event is provided for use by a set of subscribers to the event, and data related to the set of subscribers is identified. In an embodiment, a message broker in a publication and subscribe messaging environment implements the solution in order to be capable of providing the data related to the set of subscribers to the publisher. Use of the transaction ensures that the data related to the set of subscribers accurately represents the set of subscribers at the time that the data corresponding to the event was provided.Type: GrantFiled: December 19, 2008Date of Patent: June 10, 2014Assignees: International Business Machines Corporation, The United States of America as represented by National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)Inventors: Philip J. Thomas, Martin J. Gale
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Patent number: 8685411Abstract: The present invention relates to novel recombinant polypeptide antigens that may comprise subunit vaccines against rotavirus infection. Further, the present invention relates to methods for use of said antigens in the diagnosis, treatment and prevention of rotavirus infection.Type: GrantFiled: January 3, 2007Date of Patent: April 1, 2014Assignees: Children's Medical Center Corporation, The Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the National Institutes of Health (NIH), The United States of America as represented by the Dept. of Health and Human Services (DHHS)Inventors: Philip R. Dormitzer, Stephen C. Harrison, Harry B. Greenberg, Joshua Yoder
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Patent number: 8679984Abstract: An example embodiment relates to a method of manufacturing an array of electric devices that includes attaching a platform including a micro-channel structure to a substrate. The method includes injecting first and second solutions into the micro-channel structure to form at least three liquid film columns, where the first and second solutions include different solvent composition ratios and the liquid columns each, respectfully, include different solvent composition ratios. The method further includes detaching the platform the substrate, removing solvent from the liquid film columns to form thin film columns, and treating the thin film columns under different conditions along a length direction of the thin film columns. The solvent is removed from the thin film columns and the thin film columns are treated under different conditions along a length direction of the thin film columns.Type: GrantFiled: June 30, 2011Date of Patent: March 25, 2014Assignees: Samsung Electronics Co., Ltd., The United States of America as represented by the National Institutes of Health (NIH), The United States of America as represented by the Dept. of Health and Human Services (DHHS)Inventors: Jong Won Chung, Christopher J. Bettinger, Zhenan Bao, Do Hwan Kim, Bang Lin Lee, Jeong Il Park, Yong Wan Jin, Sang Yoon Lee
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Patent number: 8637040Abstract: Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antigen-binding regions of an anti-idiotypic antibody (mAb2) specific for anti-GLXA antibody (Ab1) which act as molecular mimics of GLXA are also disclosed used as immunogens to induce broadly reactive genus-specific anti-chlamydial antibodies. These peptides and immunogenic DNA encoding the mAb2-like peptides, microparticle or nanoparticle formulations and other formulations of these peptides are disclosed as are methods for immunizing subjects to obtain genus-specific anti-chlamydial antibodies and to treat or prevent Chlamydia-associated or induced rheumatoid arthritis.Type: GrantFiled: September 21, 2009Date of Patent: January 28, 2014Assignee: National Institute of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)Inventors: Judith Whittum-Hudson, Alan P. Hudson
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Patent number: 8636032Abstract: An acoustical fluid control mechanism and a method of controlling fluid flow of a working fluid with the acoustical fluid control mechanism are provided. The mechanism comprises a resonance chamber that defines a cavity. The resonance chamber has a port. The cavity is sealed from the ambient but for the port for enabling oscillatory flow of a working fluid into and out of the cavity upon exposure of the resonance chamber to an acoustic signal containing a tone at a frequency that is substantially similar to a particular resonance frequency of the resonance chamber. The mechanism further includes a rectifier for introducing directional bias to the oscillatory flow of the working fluid through the port. The rectifier has an inlet connected to the port and an outlet for transmitting the directional flow of the working fluid away from the cavity. The outlet is in fluid communication with the port of the resonance chamber at least during transmission of the directional flow of the working fluid therethrough.Type: GrantFiled: November 13, 2009Date of Patent: January 28, 2014Assignees: National Institute of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), U.S. Government of the United States as Represented by the NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Mark A. Burns, Sean M. Langelier, Dustin S. Chang
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Patent number: 8615291Abstract: Method, system, and computer program method for detecting pathological fluctuations of physiological signals to diagnose human illness. The method comprises performing a sliding window analysis to find sequences in physiological signal data that match amplitude- and duration-adjusted versions of a template function to within a specified tolerance.Type: GrantFiled: March 15, 2010Date of Patent: December 24, 2013Assignees: National Institutes of Health (NIH), The United States of America as Represented by the Department of Health and Human ServicesInventors: Randall Moorman, Douglas E. Lake, Abigail Flower, John B. Delos
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Patent number: 8491631Abstract: A tissue fixation device includes a tack having at least two flexible arms on a first end of said anchor. A deployment device for deploying a tissue fixation device, wherein the deployment device is a deployment gun.Type: GrantFiled: January 3, 2007Date of Patent: July 23, 2013Assignees: Children's Medical Center Corporation, Trustees of Boston University, National Institutes of Health (NIH), U.S. Dept. Of Health And Human Sevices (DDHHS), The United States of AmericaInventors: Pedro J. del Nido, Nikolav V. Vasilyev, Franz Freudenthal, Pierre Dupont, Jinlan Huang
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Publication number: 20130171125Abstract: The present invention relates to methods of preventing or treating cancer and/or decreasing damage to organs or tissues exposed to hypoxic conditions through the use of agents that modulate the expression or activity of SIRT3.Type: ApplicationFiled: May 11, 2011Publication date: July 4, 2013Applicant: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DDS), U.S. GovernmentInventors: Marcia C. Haigis, Lydia Finley
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Publication number: 20130156728Abstract: The present invention provides a composition effective for a neurological disease or an autoimmune disease and methods of making and using the same.Type: ApplicationFiled: May 26, 2011Publication date: June 20, 2013Applicant: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), U.S. GovernmentInventor: Daniel L. Kaufman