Patents Assigned to National Institutes of Health
  • Method of diagnosing poor survival prognosis colon cancer using let-7g
    Patent number: 8349568
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: January 8, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as Represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-10a
    Patent number: 8343725
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: January 1, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-103-2
    Patent number: 8338104
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-106a
    Patent number: 8338103
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Deparment of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-181b
    Patent number: 8338102
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-29a
    Patent number: 8338106
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-203
    Patent number: 8338105
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Tansfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Human monoclonal antibodies against hendra and nipah viruses
    Patent number: 8313746
    Abstract: The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: November 20, 2012
    Assignees: The Henry Jackson Foundation for the Advancement of Military Medicine, Inc., The United States of America, as Represented by the Secretary of the Department of Health and Human Services National Institutes of Health, Office of Technology Transfer
    Inventors: Dimiter S. Dimitrov, Zhongyu Zhu, Christopher C. Broder
  • Desferrithiocin polyether analogues
    Patent number: 8278458
    Abstract: Compounds represented by structural formulas described herein, such as Structural Formula (I): or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: October 2, 2012
    Assignees: University of Florida Research Foundation, Inc., University of Florida, The United States of America as Represented by the National Institutes of Health (NIH), The United States of America as Represented by the Department of Health and Human Services
    Inventor: Raymond J. Bergeron, Jr.
  • Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof
    Patent number: 8258172
    Abstract: The present invention provides compounds and methods of administering compounds to a subject that can reduce ?APP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce ?APP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease ?APP production.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: September 4, 2012
    Assignees: Raptor Pharmaceutical Corp, National Institutes of Health (NIH)
    Inventors: Nigel H. Greig, Karen T. Y. Shaw, Qiang-Sheng Yu, Harold W. Holloway, Tada Utsuki, Timothy T. Soncrant, Donald K. Ingram, Arnold Brossi, Anthony Giordano, Gordon Powers, Diane M. Davidson, Michael Sturgess
  • MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
    Patent number: 8252538
    Abstract: Provided herein are methods and compositions for the diagnosis, prognosis and treatment of Hepatocellular carcinoma (HCC). Also provided are methods of identifying anti-HCC agents.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: August 28, 2012
    Assignees: The Ohio State University, The United States of America as represented by the Secretary of the Department of Health and Human Services National Institute of Health, Office of Technology Transfer, Liver Cancer Institute and Zhongshan Hospital, Fudan University
    Inventors: Carlo M. Croce, Xin W. Wang, Anuradha Budhu, Zhao-you Tang
  • Dendritic cell precursors
    Patent number: 8247227
    Abstract: A method of generating a population of dendritic cell (DC) precursors includes obtaining a population of progenitor cells from a subject and culturing the progenitor cells in a culture medium. The culture medium can include Flt3 ligand and interleukin-6 and be free of granulocyte-macrophage colony-stimulating factor.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: August 21, 2012
    Assignees: The Cleveland Clinic Foundation, Trustees of the University of Pennsylvania, National Institutes of Health
    Inventors: Peter A. Cohen, Suyu Shu, Gary K. Koski, Charles S. Carter, Laura Carter, legal representative, Brian J. Czerniecki
  • Methods of Treating Pediatric Acute Lymphoblastic Leukemia with an Anti-CD22 Immunotoxin
    Publication number: 20120177567
    Abstract: The present invention provides methods for the treatment of acute lymphoblastic leukemia (ALL) in pediatric patients using an anti-CD22 immunotoxin. The methods disclosed comprise administering to a pediatric patient in need of that treatment an effective dose of a recombinant immunotoxin comprising a variable light (VL) chain linked to a variable heavy (VH) which is genetically fused to a therapeutic moiety comprising a Pseudomonas exotoxin A PE38 fragment. The recombinant immunotoxin specifically binds CD22 thereby inhibiting the growth of CD22-expressing (CD22+) ALL cancer cells.
    Type: Application
    Filed: August 11, 2011
    Publication date: July 12, 2012
    Applicants: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT, MEDIMMUNE, LLC
    Inventors: Alan S. WAYNE, Ira Pastan, Karen Kaucic, Robert Lechleider
  • COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS
    Publication number: 20120157410
    Abstract: The invention relates to compositions, conjugates and methods comprising pyridazine compounds and cholinesterase inhibitors for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
    Type: Application
    Filed: February 17, 2012
    Publication date: June 21, 2012
    Applicants: U.S. Government, National Institute of Health (NIH), U.S. Department of Health and Human Services (DHSS),
    Inventors: D. Martin WATTERSON, Linda VAN ELDIK, Wenhui HU
  • G-CSF transferrin fusion proteins
    Patent number: 8188032
    Abstract: A polypeptide comprising a G-CSF domain operably linked to a Tf domain, wherein the ability of the polypeptide to be transported into a cell expressing a TfR gene or the ability of the polypeptide to be transported across a cell expressing a TfR gene via transcytosis is higher than that of the G-CSF domain alone.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: May 29, 2012
    Assignee: National Institutes of Health (NIH)
    Inventors: Wei-Chiang Shen, Yun Bai, David Ann, Adam Widera
  • Variants in Complement Regulatory Genes Predict Age-Related Macular Degeneration
    Publication number: 20120071356
    Abstract: Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided.
    Type: Application
    Filed: August 2, 2011
    Publication date: March 22, 2012
    Applicants: University of Iowa Research Foundation, National Institutes of Health, The Trustees of Columbia University in The City of New York
    Inventors: Rando L. Allikmets, Gregory S. Hageman, Michael C. Dean, Albert M. Gold
  • Method for treating airway hyper-responsiveness with lipoxin analogs
    Patent number: 8119691
    Abstract: The use of lipoxin analogs for the treatment or prevention of asthma and asthma related diseases is described. In particular, acetylenic lipoxin analogs are effective for the treatment and prevention of eosinophil recruitment involved with the inflammation processes associated with asthma, asthma like conditions, and lung injuries associated from airway inflammation or infection as brought about by leukocyte-mediated injury from within.
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: February 21, 2012
    Assignee: National Institutes of Health (NIH)
    Inventors: Charles N. Serhan, Bruce D. Levy
  • DENDRIMER BASED NANODEVICES FOR THERAPEUTIC AND IMAGING PURPOSES
    Publication number: 20120003155
    Abstract: A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer.
    Type: Application
    Filed: June 10, 2010
    Publication date: January 5, 2012
    Applicants: NATIONAL INSTITUTES OF HEALTH, WAYNE STATE UNIVERSITY
    Inventors: Rangaramanujam M. Kannan, Sujatha Kannan, Roberto Romero, Raghavendra S. Navath, Hui Dai, Anupa R. Menjoge
  • SCHWEINFURTHIN ANALOGUES
    Publication number: 20110319481
    Abstract: Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods comprising administering such analogs.
    Type: Application
    Filed: January 26, 2011
    Publication date: December 29, 2011
    Applicants: Government of the United States of America, National Institute of Health, University of Iowa Research Foundation
    Inventors: David F. Wiemer, Jeffrey D. Neighbors, John A. Beutler
  • Method of diagnosing poor survival prognosis colon cancer using microRNA-21
    Patent number: 8084199
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: December 27, 2011
    Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Department of Health and Human Services, National Institutes of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter