Abstract: A method for characterizing an aggregate sample involves using a first laser pulse to create a crater on the surface of a sample, using a second laser pulse to produce a plasma emission spectrum on the prepared crater surface, and detecting the emission spectrum to collect spectral data. Laser application, and detecting spectral emission are repeated on different points on the sample, then non-representative spectral data is discarded based on a ratio of ions to atoms in the data. Finally a calibration loading is used to determine a property characteristic of the aggregate sample. The sample may be an oil sands sample, and the properties detected may be percentages of bitumen, water, and solids. A laser-based system is provided for carrying out the characterization method.
Type:
Grant
Filed:
November 29, 2017
Date of Patent:
August 17, 2021
Assignee:
National Research Council of Canada (NRC)
Inventors:
Aissa Harhira, Mohamad Sabsabi, Josette El Haddad, Alain Blouin
Abstract: Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabichromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
Type:
Grant
Filed:
June 17, 2019
Date of Patent:
July 28, 2020
Assignee:
National Research Council of Canada (NRC)
Abstract: A method for characterizing an aggregate sample involves using a first laser pulse to create a crater on the surface of a sample, using a second laser pulse to produce a plasma emission spectrum on the prepared crater surface, and detecting the emission spectrum to collect spectral data. Laser application, and detecting spectral emission are repeated on different points on the sample, then non-representative spectral data is discarded based on a ratio of ions to atoms in the data. Finally a calibration loading is used to determine a property characteristic of the aggregate sample. The sample may be an oil sands sample, and the properties detected may be percentages of bitumen, water, and solids. A laser-based system is provided for carrying out the characterization method.
Type:
Application
Filed:
November 29, 2017
Publication date:
November 14, 2019
Applicant:
National Research Council Of Canada (NRC)
Inventors:
Aissa HARHIRA, Mohamad SABSABI, Josette EL HADDAD, Alain BLOUIN
Abstract: The invention provides chimeric DGAT1 proteins comprising: a) at their N-terminal ends, an N-terminal portion of a first DGAT1 protein, and b) at their C-terminal ends, a C-terminal portion of a second DGAT1 protein. The chimeric DGAT proteins show enhanced activity relative to at least one of the first DGAT1 protein and the second DGAT1 protein. The chimeric DGAT proteins of the invention can be expressed in cells to increase cellular lipid accumulation and/or modify the cellular lipid profile. The invention also provides polynucleotides encoding the chimeric DGAT1 proteins, cells and compositions comprising the polynucleotides or chimeric DGAT1 proteins, and methods using the chimeric DGAT1 proteins to produce oil.
Type:
Application
Filed:
October 22, 2013
Publication date:
October 8, 2015
Applicants:
National Research Council of Canada (NRC), Agresearch Limited
Inventors:
Nicholas John Roberts, Amy Christina Curran, Somrutai Winichayakul, Marissa Roldan, Richard William Scott, David Charles Taylor, Elizabeth-France Marillia
Abstract: The disclosure generally describes carrier resins, and in particular, resins used for carrier coatings which include at least one ester functional group and at least one cyclic aliphatic group containing at least one nitrogen atom in the cyclic ring structure. Carriers having such resins in the coating exhibit high charge and excellent relative humidity (RH) sensitivity of charge to changing environmental conditions.
Type:
Application
Filed:
April 3, 2013
Publication date:
October 9, 2014
Applicants:
National Research Council of Canada ("NRC"), XEROX CORPORATION
Inventors:
RICHARD P. VEREGIN, Qingbin Li, Andriy Kovalenko, Sergey Gusarov, Darren Makeiff, Valerie Farrugia, Michael S. Hawkins
Abstract: A phage-displayed library of llama single heavy domain antibodies (sdAbs) was enriched for species that selectively bind to and are internalized by human cerebromicrovascular endothelial cells (HCEC). From the enriched library, two sdAbs were selected, sequenced, subcloned, and expressed as fusion proteins with c-myc-His5 tags. Similarly as phage-displayed sdAbs, these soluble tagged sdAbs were shown to selectively bind to HCEC and to transmigrate across in vitro human blood-brain barrier (BBB) model. In contrast to an unrelated llama sdAb, these sdAbs were also detected in the brain after i.v. injection into mice. These small (˜13 kDa) antibody fragments have essential characteristics of brain-specific delivery vectors and can be used to facilitate drug transport across the BBB.
Type:
Application
Filed:
March 21, 2011
Publication date:
July 14, 2011
Applicant:
National Research Council of Canada NRC Communications & Corporate Relations