Abstract: The present disclosure describes a polyester that contains plural pendant adjacent carboxylic acid or acid salt side groups for use in making a toner for use in imaging devices.

Abstract: A catecholamine or related compound having (S)-configuration at ?-carbon, a physiologically tolerated salt thereof, a prodrug thereof, a physiologically functional derivative thereof or any mixture thereof and having a lipophilicity greater than (S)-noradrenaline has use as an anti-angiogenic agent. A catecholamine or related compound in which a ?-hydroxy group has been modified are also anti-angiogenic. The anti-angiogenic agent is preferably a compound of formula (I) or (II) a physiologically tolerated salt thereof, a prodrug thereof, a physiologically functional derivative thereof or any mixture thereof.

Abstract: A method for applying a coating to a substrate surface is provided. The method involves cold spraying a coating material against the surface of the substrate at a first velocity. The first velocity is lower in magnitude than a critical velocity. The method also involves cold spraying the coating material against the surface of the substrate at a second velocity. The second velocity is greater in magnitude than the critical velocity. The critical velocity is a threshold velocity below which the coating material is substantially deflected by the surface of the substrate and above which the coating material substantially adheres to the surface of the substrate.

Abstract: A method for applying a coating to a substrate surface is provided. The method involves cold spraying a coating material against the surface of the substrate at a first velocity. The first velocity is lower in magnitude than a critical velocity. The method also involves cold spraying the coating material against the surface of the substrate at a second velocity. The second velocity is greater in magnitude than the critical velocity. The critical velocity is a threshold velocity below which the coating material is substantially deflected by the surface of the substrate and above which the coating material substantially adheres to the surface of the substrate.

Abstract: A method for analysis of the extent of conscious awareness and likelihood of recovery of a patient includes the steps of applying to the patient a sensory stimulus sequence which is typically auditory; carrying out an EEG to generate waveform signals to record changes in the electromagnetic fields generated by the patient's neural activity; using software provided in a processor to process the waveform signals in order to locate waveform peaks, identify the event-related potential (ERP) components obtained in the waveform and to obtain quantitative measures of those components; and using the software to generate and communicate scores indicative of the extent of conscious awareness and likelihood of recovery of the patient.

Abstract: The invention relates to antibodies specific to serum albumins. More specifically, the invention relates to camelid single domain antibodies and pentabodies binding to serum albumins of various species with various affinities.

Abstract: Dextrans produced by lactic acid bacteria Leuconostoc mesenteroides and consisting of linear ?1,6-glucan chains modified with short side-chains composed of consecutive ?1,6-linked glucose residues were linked to a carrier protein. Three dextrans, namely Dextran-5K, Dextran-3.5K and Dextran-1.5K, with molecular masses of 5,000 Da, 3,500 Da and 1,500 Da, respectively, were modified with a diamino group-containing linker, followed by the introduction of maleimido functionality and conjugation to thiolated tetanus toxoid (TT), yielding Dextran-5K-TT, Dextran-3.5K-TT and Dextran-1.5K-TT conjugates. Studies performed with post-immune sera of mice and rabbits immunized with dextran-based glycococonjugates demonstrated cross-reactivity with LPS from typeable and non-typeable H. pylori strains and selected mutants. The post-immune sera from rabbits that received the conjugates exhibited functional activity against ?1,6-glucan-positive strains of H.

Abstract: The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments thereof as well as their use in therapy or prophylaxis.

Abstract: Modified carbon nanotubes are provided having carbon nanotube core covalently bound through C—C bonds to a polymer shell surrounding the carbon nanotube core. The polymer shell is a polymer having functional groups pointing outwardly from the shell. The functional groups are compatible with or able to covalently connect to another polymer. Such modified carbon nanotubes are more readily dispersed in a homogeneous manner in another polymer and may be used as a reinforcing filler in a polymer matrix. The modified carbon nanotubes with a core-shell structure in which the core has a substantially unidirectional orientation within the shell are produced by reacting neutral carbon nanotubes with 4-vinylaniline through a diazonium reaction in presence of one or more types of multifunctional monomers carrying a vinyl moiety and one or more functional groups for compatibilization with or connection to another polymer.

Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.

Abstract: Polypeptides with desirable biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human VHs and VLs, are identified using a high throughput method for screening polypeptides, comprising the steps of obtaining a phage display library, allowing infection of a bacterial lawn by the library phage, and identifying phage which form larger than average plaques on the bacterial lawn. Sequences of monomeric human VHs and VLs are identified, which may be useful for immunotherapy or as diagnostic agents. Multimer complexes of human VHs and VLs are also identified. The VHs and VLs identified may be used to create further libraries for identifying additional polypeptides. Further, the VHs and VLs may be subjected to DNA shuffling to select for improved biophysical properties.

Abstract: A system for cold gas dynamic spraying of particulate material has a de Laval nozzle and two or more radial particle inlets located between the throat and the outlet of the nozzle, the two or more particle inlets arranged symmetrically around a linear flow path of the nozzle. Blocking of the inlets is reduced by controlling pressure of particle carrier gas to provide a stable particulate material injection pressure before and during introduction of working gas into the nozzle, and/or by clearing the particle inlets of residual particles after a spraying process. Such a system and associated method combines benefits of both downstream and upstream cold gas spray systems. Further, a nozzle for spraying particulate material having a cross-sectional shape that is narrower in a middle section compared to edge sections provides coatings with superior cross-sectional profiles.

Abstract: A composition made of at least 60 wt. % of a thermoplastic elastomer resin and additives that are solid at least from 0-50° C., that has a Shore A hardness that is less than about 50 bears a patterned surface, the pattern comprising at least one microfluidic channel having a cross-sectional dimension smaller than 100 microns is a substrate for forming a microfluidic device. The chief advantages of such compositions are: its ability to bond in a sealing manner to smooth surfaces of many different compositions, its ease of manufacture and microstructure patterning, and its general impermeability to liquids.

Abstract: Use of Ca in metal matrix composites (MMC) allows for incorporation of small and large amounts of ceramic (e.g. rutile Ti02) into the metal (Al, or its alloys). Calcium remains principally out of the matrix and is part of a boundary layer system that has advantages for integrity of the MMC. Between 0.005 and 10 wt. % calcium (Ca) may be included, and more than 50 wt. % of rutile has been shown to be integrated. Rutile may therefore be used to reduce melt loss due to calcium from an aluminum or aluminum alloy melt.

Abstract: The disclosure describes dry acrylate resin particles, optionally, with a C/O of at least about 4, comprising a heterocycle comprising sulfur, exhibiting high charge and improved RH sensitivity.

Abstract: A bone screw and method of producing the same is described. The method of producing a bone screw includes forming a one-piece headless screw body out of a rigid metallic foam that is entirely porous throughout and defines a plurality of inter-connected pores having a size of about 30 to about 500 microns in diameter. The method includes providing at least one thread on an external surface of the screw body, and forming a bore extending through an entire axial length of the screw body, the bore forming a cannula that defines an annular radial wall thickness of the screw body. The method further includes disposing the inter-connected pores throughout the radial wall thickness of the screw body such as to allow for bone in-growth through the full radial wall thickness and into the cannula.

Abstract: Efficient and muscle-specific gene expression can be obtained with constructs containing two or more copies of USE and/or ?USE fused to the minimal promoter of the TnISlow gene. USE is a small (about 160-bp) upstream enhancer of the TnISlow gene that confers slow-twitch muscle fiber specificity. ?USE is generated from a 100-bp deletion at the 5? end of USE. ?USE confers expression in slow- and fast-twitch muscle fibers. The strength and relatively small size (less than 600-bp) of these constructs make them useful for gene therapy applications.

Abstract: A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed thereform.

Abstract: A technique for protecting a structure from an impact with ice involves providing a horizontal spall initiator extending from the wall a distance of 1 to 10 cm, the horizontal spall initiator being resilient to the ice impact, and formed by blade segments having a blade width less than ½ a thickness of an expected hard zone of the ice; and situating the horizontal spell initiator at an elevation of the expected hard zone. Situating the horizontal spall initiator at an elevation of the hard zone may involve providing an elevation control mechanism (e.g. buoyancy, mechanical, or hydrodynamic), or may involve a panel with a plurality of horizontal spell initiators at respective elevations. The horizontal spell initiator may be driven.

Abstract: A new approach for improving fire resistance of cellulosic materials is provided, especially when the cellulosic material is to be used in polymer composites. Cellulosic material is treated with an aqueous mixture of alkali metal or ammonium hydroxide and alkaline earth or aluminum metal salt simultaneously with or within a short period of time of preparing the mixture. The treated cellulosic material becomes self-extinguishing and may also have improved thermal stability, improved interfacial thermal resistance, improved resistance to damage by oxidants and other chemical agents, improved resistance to biological agents and/or improved resistance to damage by ultra-violet light.