Patents Assigned to National Sun Yat-Sen University
  • Publication number: 20240352097
    Abstract: The present disclosure provides a neutralizing antibody for flaviviruses, a production method, a method of treating or preventing a flaviviruses infection in a subject, and the use thereof.
    Type: Application
    Filed: April 17, 2024
    Publication date: October 24, 2024
    Applicant: National Sun Yat-sen University
    Inventors: Day-Yu CHAO, Yen-Hsu Chen, Wen-Hung Wang
  • Patent number: 12105365
    Abstract: A light reflecting device includes two substrates and a liquid crystal layer. The two substrates are parallel to each other and respectively electrically connected to a voltage source to generate an electric field therebetween. Each of the two substrates has an inner surface having a horizontal orientation. The liquid crystal layer is formed by liquid crystal materials filled between the two substrates. The liquid crystal materials include liquid crystal molecules and ions of salt species. The liquid crystal molecules are at least formed by negative liquid crystals and chiral molecules. The liquid crystal layer is respectively switched to a diffuse reflection state and a specular reflection state by applying the electrical field generated by the voltage source in a first frequency and a second frequency. The second frequency is higher than the first frequency.
    Type: Grant
    Filed: February 15, 2024
    Date of Patent: October 1, 2024
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Tsung-Hsien Lin, Cheng-Chang Li, Li-Min Chang, Duan-Yi Guo, Kuan-Wu Lin
  • Patent number: 12098463
    Abstract: A method for manufacturing an amorphous multielement metal oxide hydroxide film includes: A liquid mixture is formed by dissolving an oxidizing agent selected from a group consisting of potassium permanganate, potassium chromate, potassium dichromate and potassium ferrate, and a reducing agent in a solvent. The oxidizing agent forms an oxometallate anion having a first metal atom with a first valence number. The reducing agent forms a metal cation having a second metal atom with a third valence number. An amorphous multielement metal oxide hydroxide film is deposited on a substrate by soaking the substrate in the liquid mixture. The amorphous multielement metal oxide hydroxide film includes a multielement metal oxide hydroxide having the first metal atom with a second valence smaller than the first valence number and the second metal atom with a fourth valence number larger than the third valence number.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: September 24, 2024
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Chun-Hu Chen, Ren-Huai Jhang, Chang-Ying Yang
  • Patent number: 12092872
    Abstract: A waveguide division multiplexer and demultiplexer includes a first-stage Mach-Zehnder interferometer (MZI) and two second-stage MZIs. The first-stage MZI includes two input ends and two output ends, in which one of the inputs is configured to receive an input optical beam with a first center wavelength and a second center wavelength, and the output ends are configured to respectively transmit first-stage output optical beams respectively with the first center wavelength and the second center wavelength. One input terminals of the second-stage MZI are configured to respectively receive the first-stage output optical beams, and one output terminals of the second-stage MZI are configured to transmit second-stage output optical beams with the first and second center wavelengths, respectively. Each second-stage MZI is configured in cross-state condition.
    Type: Grant
    Filed: September 20, 2022
    Date of Patent: September 17, 2024
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Yung-Jr Hung, Tzu-Hsiang Yen
  • Patent number: 12044574
    Abstract: A non-contact body temperature measurement device includes a thermal imager, an anemometer and a processing unit. The thermal imager is provided to capture thermal images. The anemometer is provided to measure wind speed and output a wind speed signal. The processing unit is provided to process the thermal images according to the wind speed signal and remove the thermal image showing great variation in temperature between two consecutive frames. Consequently, an accurate body temperature can be measured through the processed thermal images.
    Type: Grant
    Filed: July 28, 2022
    Date of Patent: July 23, 2024
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Fu-Kang Wang, Pin-Hsun Juan, Ya-Chi Su, Yu-Chieh Wang, Ju-Yin Shih
  • Patent number: 11963985
    Abstract: The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.
    Type: Grant
    Filed: July 12, 2023
    Date of Patent: April 23, 2024
    Assignee: National Sun Yat-Sen University
    Inventors: Zhi-Hong Wen, Ping-Jyun Sung, Han-Chun Hung, Chun-Hong Chen, Yu-Chia Chang
  • Patent number: 11915445
    Abstract: A system and a method for counting aquatic creatures are provided. The system includes an image capture device and a computer system configured to perform the method. The method includes: using the image capture device to capture images of a flow channel; defining a scan line in the images; performing a binarization process on pixels of the scan line in each of the images; determining aquatic creature range data according to each of the binarized pixel data sets; determining aquatic creature range data sets according to the binarized pixel data sets; determining identification and direction information of aquatic creature corresponding to each of the aquatic creature range data sets according to the aquatic creature range data sets; and determining a number of aquatic creatures passing through the scan line according to the identification and direction information of aquatic creature corresponding to each of the aquatic creature range data sets.
    Type: Grant
    Filed: December 31, 2020
    Date of Patent: February 27, 2024
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventor: Ing-Jer Huang
  • Publication number: 20240026957
    Abstract: A conjugate cam reducer includes input and output units disposed at two opposite sides of a transmission unit. The transmission unit includes smaller-diameter and larger-diameter cam discs axially connected with each other. The smaller-diameter and larger-diameter cam discs have first and second grooves. The input unit includes an input disc, an eccentric shaft and a plurality of input rollers. The input disc has a smaller inner peripheral wall engaging with the smaller-diameter cam disc, and a plurality of first receiving grooves registered with the first grooves to receive the input rollers. The eccentric shaft is rotated to drive rotation of the transmission unit in an eccentric cycloidal motion. The output unit includes an output disc having a larger inner peripheral wall which engages with the larger-diameter cam disc, and a plurality of second receiving grooves which are registered with the second grooves to receive a plurality of output rollers.
    Type: Application
    Filed: December 13, 2022
    Publication date: January 25, 2024
    Applicant: National Sun Yat-Sen University
    Inventors: Der-Min TSAY, Kun-Lung HSU, Wei-Ming CHEN, Jyun-Ting CHEN, Yuan-Shin LIN
  • Patent number: 11877800
    Abstract: A method and a system for detecting blepharoptosis are disclosed. The method and the system include image capturing via a camera to generate three eye images; executing an image processing on the eye images to generate the corresponding border images; executing an image computing on the eye image and the corresponding border image to obtain a plurality of characteristic variables; performing a calculation according to the plurality of characteristic variables to obtain a characteristic parameter set; and comparing the characteristic parameter set with a preset blepharoptosis criteria information to obtain a blepharoptosis severity and a levator function.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: January 23, 2024
    Assignees: KAOHSIUNG MEDICAL UNIVERSITY, NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Chun-Sheng Lai, Yi-Wu Chiang
  • Patent number: 11866516
    Abstract: The present invention relates to an isolated peptide, an anti-cancer medicinal composition including the same and a method of specifically reducing or inhibiting activities of cancer cells using the same. The isolated peptide including a TAT basic domain conjugated to a GABARAPL2 H2 domain can specifically reduce or inhibit an activity of cancer cells, thereby being applied to the anti-cancer medicinal composition and the method of specifically reducing or inhibiting activities of cancer cells using the same.
    Type: Grant
    Filed: June 16, 2022
    Date of Patent: January 9, 2024
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventor: Chih-Wen Shu
  • Patent number: 11835618
    Abstract: A multiple-target vital sign detector includes a self-injection-locked oscillator (SILO), a chirp up/down converter, a frequency demodulator and a multiple-target vital sign processor. The chirp up/down converter performs conversion from an oscillation signal generated by the SILO to a frequency-modulated continuous wave (FMCW) signal to detect an area and from a received FMCW signal reflected from the area to an injection signal, while the SILO is injected with the injection signal to enter a self-injection-locked state. The locations and vital signs of multiple subjects are extracted from the oscillation signal using the frequency demodulator and the multiple-target vital sign processor. The objective of using the SILO is to improve the sensitivity of the FMCW detection process so as to more effectively distinguish the vital signs of multiple subjects at different locations.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: December 5, 2023
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Tzyy-Sheng Horng, Fu-Kang Wang, Wei-Chih Su, Mu-Cyun Tang, Rezki El Arif
  • Patent number: 11808834
    Abstract: A phased-array Doppler radar includes a two-way splitter, a transmit antenna, a receive antenna array, an ILO, a demodulation unit and a digital signal processing unit. A reference signal is split by the two-way splitter to the transmit antenna for transmission to targets and the ILO for injection locking. Signals reflected by the targets are received by the receive antenna array as received signals. An injection-locked signal generated by the ILO and the received signals received by the receive antenna array are delivered to the demodulation unit. The received signals are demodulated into baseband I/Q signals by the demodulation unit that uses the injection-locked signal as a local oscillator signal. The baseband I/Q signals are processed by the digital signal processing unit to obtain a digital beamforming pattern.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: November 7, 2023
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Tzyy-Sheng Horng, Chao-Kai Wen, Yi-Chen Lai, Yu-Chi Huang, Jui-Yen Lin, De-Ming Chian
  • Patent number: 11796840
    Abstract: An electrically controlled polarization rotator is disclosed. The electrically controlled polarization rotator includes two substrates and a liquid crystal layer located between the two substrates. The two substrates have a homogeneous alignment and a homeotropic alignment respectively. A distance between the two substrates is a liquid crystal thickness. A switching electric field which is adjustable is provided between the two substrates. A polarized light is incident on the substrate having the homogeneous alignment. A polarization direction of the polarized light is orthogonal or parallel to an alignment direction of the substrate having the homogeneous alignment. A birefringence of the liquid crystal layer multiplied by the liquid crystal thickness and further divided by a wavelength of the polarized light is greater than 10. The polarization direction of the polarized light is rotated corresponding to an intensity of the switching electric field in the liquid crystal layer.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: October 24, 2023
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Tsung-Hsien Lin, Heng-Yi Tseng, Cheng-Chang Li, Duan-Yi Guo, Li-Min Chang, Kuan-Wu Lin
  • Patent number: 11780877
    Abstract: The present invention provides a method of sugar-guided modifying a glycosylated polypeptide. First, a boronic acid group of a probe molecule and a sugar group of the glycosylated polypeptide form a first covalent bond. Next, an alkyne group of a modifying group and an azide group of the probe molecule form a second covalent bond by adding a promoter. As a result, the modifying group can be close to the glycosylated polypeptide. Then, the modifying group can bind to a nucleophilic residue that is near the sugar group, through a nucleophilic addition reaction. The method of the present invention can selectively modify a given site with the guidance of the sugar group.
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: October 10, 2023
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Po-Chiao Lin, Chih-Hung Chou
  • Patent number: 11747458
    Abstract: A FCFMSIL radar includes a SILO, a frequency conversion unit, an antenna unit, a demodulation unit and a processing unit. The frequency conversion unit converts an oscillation signal of the SILO into a FMCW signal. The antenna unit transmits the FMCW signal to an area as a transmitted signal and receives a reflected signal from the area as a received signal. The frequency conversion unit converts the received signal into an injection signal and injects it into the SILO. The demodulation unit demodulates the oscillation signal into an in-phase demodulated signal and a quadrature demodulated signal. The processing unit processes the in-phase and the quadrature demodulated signals to obtain a baseband signal and thus acquire a phase and a frequency of a tone in the frequency-domain baseband signal, and determines the tone corresponding to one or multiple objects based on the phase and frequency of the tone.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: September 5, 2023
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Fu-Kang Wang, Pin-Hsun Juan, Chao-Kai Wen, De-Ming Chian
  • Patent number: 11738055
    Abstract: The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: August 29, 2023
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Zhi-Hong Wen, Ping-Jyun Sung, Han-Chun Hung, Chun-Hong Chen, Yu-Chia Chang
  • Publication number: 20230238079
    Abstract: The present invention relates to a method and a kit, a computer-implemented method and a system for in vitro predicting survival time of an individual with bladder cancer after surgery from an individual's biological sample. Expression levels of a target gene combination of in vitro aggressive bladder cancer specimen of a patient are detected, and the target gene combination includes at least two of PPT2, ARMH4, P4HB, SLC1A6 and ARID3A, a fragment, a homologue, a variant and a derivative thereof. Next, the expression levels are respectively compared with the reference expression levels of a reference database, and converted to a risk score sum, thereby predicting an averaged survival time of a patient having aggressive bladder cancer after surgery, and being beneficially applied to a kit and a computer-implemented method for in vitro predicting survival time of patient with most aggressive types of bladder cancer after surgery.
    Type: Application
    Filed: December 27, 2022
    Publication date: July 27, 2023
    Applicant: National Sun Yat-Sen University
    Inventors: Jim Jinn-Chyuan Sheu, Chung Chang, Bo-Chen Lin, Li-Yun Yang, You-Jun Lai
  • Patent number: 11668376
    Abstract: A cam transmission mechanism includes a rotary disk, a camshaft, contact members and a housing. The rotary disk has a periphery formed with equidistant projections, any two adjacent ones of which define an accommodating recess. The camshaft includes a shaft rod and a cam body that has at least one groove communicated with some of the recesses of the rotary disk. The groove and the recesses cooperate to form a plurality of confining spaces, within which the contact members are accommodated freely rollably for rotation transfer from the camshaft to the rotary disk. The housing is connected to the rotary disk for confining the contact members in the confining spaces, respectively.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: June 6, 2023
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Der-Min Tsay, Kun-Lung Hsu, Wei-Ming Chen
  • Patent number: 11669634
    Abstract: A provided method includes: obtaining a predictor matrix having at least one masked attribute; obtaining a response matrix; setting that the predictor matrix is approximated by a product of a basis matrix and a coefficient matrix; setting that the response matrix is approximated by a product of a weight matrix, a projection matrix and the predictor matrix; setting that the basis matrix, the coefficient matrix, the weight matrix, and the projection matrix are nonnegative; setting that the projection matrix, the weight matrix, or a product of the projection matrix and the predictor matrix is orthogonal, and thus setting a cost function; and calculating the basis matrix, the coefficient matrix, the weight matrix, and the projection matrix according to the cost function. Accordingly, operations of imputation, fitting, and subspace analysis can be performed.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: June 6, 2023
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventor: Bo-Wei Chen
  • Patent number: 11662453
    Abstract: A digital self-injection-locked (SIL) radar includes a digital SIL oscillator, a wireless signal transceiver and a digital frequency demodulator. The digital SIL oscillator generates a digital output signal. The wireless signal transceiver is electrically connected to the digital SIL oscillator to convert the digital output signal into a wireless signal for transmission to a target, receives a reflected signal from the target, and converts the reflected signal into a digital injection signal for injection into the digital SIL oscillator. Accordingly, the digital SIL oscillator operates in an SIL state and generates a digital oscillation signal. The digital frequency demodulator is electrically connected to the digital SIL oscillator to receive and demodulate the digital oscillation signal into a digital demodulation signal.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: May 30, 2023
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Shiang-Hwua Yu, Tzyy-Sheng Horng, Wei-Chih Su