Abstract: The present invention provides a novel compound capable of inhibiting cardiac adenylyl cyclase. The present invention relates to a compound represented by the following formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof: where R1, R2 and R3 each independently represent a hydrogen atom or an acyl group having an acidic or basic substituent, provided that all of R1, R2 and R3 are not simultaneously a hydrogen atom. The present invention also provides a modulator of adenylyl cyclase activity, a pharmaceutical composition and a food composition, all of which comprise the above-described compound or a pharmaceutically acceptable salt, ester or solvate thereof.

Abstract: An approximation processing method for approximating a point group using a curve or a surface defined by control points includes a step of forming an approximated curve (surface) using control points that retain features of a shape; a first calculation step of calculating a closest point closest to each of the data points on the approximated curve (surface); a second calculation step of calculating an error vector that joins the closest point, obtained in the first calculation step, to the data point; and a third calculation step of calculating a corrected control point by moving each of the control points based on the error vector obtained by the second calculation step. The step of forming an approximated curve (surface) and the first to third calculation steps are repeated to make the approximated curve (surface) respectively approximate the curve (surface) of an object configured by the data points.