Patents Assigned to National University Corporation Niigata University
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Patent number: 11485974Abstract: The present invention provides methods for retaining and expressing physiologically active substances in a target tissue-specific-manner, by administering the physiologically active substances to target submucous tissue. Specifically, the present inventors demonstrated that, when physiologically active substances were directly administered into submucous tissues without using a carrier, the physiologically active substances were effectively and safely retained at the administration sites over long periods without loss and diffusion, and produced the effect acting in a reservoir-like fashion. The physiologically active substances administered as described above were demonstrated to produce the therapeutic effect without having an influence on organs other than the administered organ.Type: GrantFiled: May 8, 2020Date of Patent: November 1, 2022Assignees: STELIC INSTITUTE & CO., (NATIONAL UNIVERSITY CORPORATION) NIIGATA UNIVERSITY :Inventors: Hiroyuki Yoneyama, Kenji Suzuki
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Publication number: 20210040478Abstract: The present invention provides methods for retaining and expressing physiologically active substances in a target tissue-specific-manner, by administering the physiologically active substances to target submucous tissue. Specifically, the present inventors demonstrated that, when physiologically active substances were directly administered into submucous tissues without using a carrier, the physiologically active substances were effectively and safely retained at the administration sites over long periods without loss and diffusion, and produced the effect acting in a reservoir-like fashion. The physiologically active substances administered as described above were demonstrated to produce the therapeutic effect without having an influence on organs other than the administered organ.Type: ApplicationFiled: May 8, 2020Publication date: February 11, 2021Applicants: STELIC INSTITUTE & CO., (NATIONAL UNIVERSITY CORPORATION) NIIGATA UNIVERSITYInventors: Hiroyuki YONEYAMA, Kenji SUZUKI
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Patent number: 10689650Abstract: The present invention provides methods for retaining and expressing physiologically active substances in a target tissue-specific-manner, by administering the physiologically active substances to target submucous tissue. Specifically, the present inventors demonstrated that, when physiologically active substances were directly administered into submucous tissues without using a carrier, the physiologically active substances were effectively and safely retained at the administration sites over long periods without loss and diffusion, and produced the effect acting in a reservoir-like fashion. The physiologically active substances administered as described above were demonstrated to produce the therapeutic effect without having an influence on organs other than the administered organ.Type: GrantFiled: February 6, 2019Date of Patent: June 23, 2020Assignees: STELIC INSTITUTE & CO., (NATIONAL UNIVERSITY CORPORATION) NIIGATA UNIVERSITYInventors: Hiroyuki Yoneyama, Kenji Suzuki
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Publication number: 20190246457Abstract: An infrared heater includes a heater body and a casing. The heater body includes a heating element and a metamaterial structure capable of emitting infrared radiation having a peak wavelength of a non-Planck distribution when thermal energy is supplied from the heating element. The casing has an interior space in which the heater body is disposed and whose pressure is reducible. In addition, the casing includes an infrared radiation transmitting portion capable of transmitting the infrared radiation emitted by the metamaterial structure to an outside of the casing.Type: ApplicationFiled: April 17, 2019Publication date: August 8, 2019Applicants: NGK INSULATORS, LTD., National University Corporation Hokkaido University, National University Corporation Niigata UniversityInventors: Michiro AOKI, Yoshio Kondo, Tsuyoshi Totani, Atsushi Sakurai
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Publication number: 20190153447Abstract: The present invention provides methods for retaining and expressing physiologically active substances in a target tissue-specific-manner, by administering the physiologically active substances to target submucous tissue. Specifically, the present inventors demonstrated that, when physiologically active substances were directly administered into submucous tissues without using a carrier, the physiologically active substances were effectively and safely retained at the administration sites over long periods without loss and diffusion, and produced the effect acting in a reservoir-like fashion. The physiologically active substances administered as described above were demonstrated to produce the therapeutic effect without having an influence on organs other than the administered organ.Type: ApplicationFiled: February 6, 2019Publication date: May 23, 2019Applicants: STELIC INSTITUTE & CO., (NATIONAL UNIVERSITY CORPORATION) NIIGATA UNIVERSITYInventors: Hiroyuki YONEYAMA, Kenji SUZUKI
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Publication number: 20120125770Abstract: A hydrogen gas sensor comprising a detection electrode, a reference electrode, and an electrolyte contacting with these electrodes, in which the reference electrode and the detection electrode are composed of a material having a property that hydrogen molecule doesn't voluntarily dissociate into atomic hydrogen on a surface of the electrode in Standard State such as nickel, titanium, copper, tungsten and the like, in which hydrogen gas is detected by an electromotive force generated between the reference electrode and the detection electrode while at least the detection electrode is maintained at a temperature not less than a temperature that hydrogen molecule begins to dissociate into atomic hydrogen voluntarily on the surface of the detection electrode.Type: ApplicationFiled: May 21, 2010Publication date: May 24, 2012Applicant: NATIONAL UNIVERSITY CORPORATION NIIGATA UNIVERSITYInventors: Shuji Harada, Tatsuya Ishiduka, Tsuneo Nakamura
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Publication number: 20060099593Abstract: An object of the present invention is. to provide an objective method for diagnosis of schizophrenia using gene expression in mononuclear cells of peripheral blood as an index, and this invention provide a method for diagnosing whether a test subject suffers from schizophrenia or not.Type: ApplicationFiled: September 26, 2003Publication date: May 11, 2006Applicants: Japan Science and Technology Agency, National University Corporation Niigata UniversityInventors: Hiroyuki Nawa, Toshiyuki Someya, Tatsuyuki Muratake, Meiko Kawamura