Patents Assigned to National University Corporation Okayama University
  • Publication number: 20220280601
    Abstract: This invention provides a method for treatment of hepatic cancer with the use of an anti-tumor agent in combination with the REIC/Dkk-3 gene. This invention also provides a therapeutic agent for treatment of hepatic cancer used in combination with an anti-tumor agent, which comprises, as an active ingredient, the REIC/Dkk-3 gene.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 8, 2022
    Applicants: Momotaro-Gene Inc., NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Hiromi KUMON, Hidenori SHIRAHA, Atsushi OYAMA, Daisuke UCHIDA, Masaya IWAMURO, Hiroyuki OKADA
  • Patent number: 11401604
    Abstract: A film formation method is provided with a step for disposing a non-electroconductive long thin tube 102 in a chamber 101 in which the internal pressure thereof is adjustable, generating a plasma inside the long thin tube 102 in a state in which a starting material gas including a hydrocarbon is supplied, and forming a diamond-like carbon film on an inner wall surface of the long thin tube 102. The long thin tube 102 is disposed in the chamber 101 in a state in which a discharge electrode 125 is disposed in one end part of the long thin tube 102 and the other end part is open. An alternating-current bias is intermittently applied between the discharge electrode 125 and a counter electrode 126 provided so as to be separated from the long thin tube 102.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: August 2, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Yuichi Imai, Tatsuyuki Nakatani, Susumu Ozawa, Yasuhiro Fujii, Haruhito Uchida
  • Patent number: 11390897
    Abstract: The present invention relates to a method including culturing a C1 compound-assimilating bacterium, which is a methylotroph, and/or a yeast by using a medium comprising, for example, a C1 compound and/or glycerol as a carbon source, to thereby produce EGT.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: July 19, 2022
    Assignee: National University Corporation Okayama University
    Inventor: Akio Tani
  • Patent number: 11380906
    Abstract: According to an aspect of the present invention, there is provided a positive electrode material which contains a positive electrode active material, and a dielectric material having a perovskite crystal structure. In the positive electrode material, in an X-ray diffraction pattern (vertical axis: diffraction intensity, horizontal axis: diffraction angle 2? (rad)) obtained by X-ray diffraction measurement using a CuK? ray, a highest intensity peak which is a peak derived from the dielectric material and has the highest intensity is in a range satisfying 2?=31° to 32°, and a half width x of the highest intensity peak satisfies the following expression: 0.22?x?0.33.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: July 5, 2022
    Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Daisuke Horikawa, Ryuta Sugiura, Takashi Teranishi
  • Publication number: 20220176016
    Abstract: The present invention addresses the problem of providing, by a method in which an expensive manufacturing apparatus is not required, an implant material having osteoconductivity superior to that of an implant material containing an aromatic polyether ketone. The present invention pertains to: said method including immersing an aromatic polyether ketone in a strong base solution in the absence of a calcium ion, and immersing an aromatic polyether ketone, which is obtained by the immersing, in a liquid containing a phosphorus-containing compound; and an implant material obtained by said method.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 9, 2022
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, SHINSHU UNIVERSITY, FUKUOKA UNIVERSITY
    Inventors: Takumi Okihara, Yoshiki Takada, Naoto Saito, Kaoru Aoki, Naoyuki Nishimura, Hisao Haniu, Shigeaki Moriyama, Katsuya Ueda
  • Publication number: 20220154369
    Abstract: The method for producing wet spun fibers/a wet formed film using a double-walled pipe type micronozzle apparatus according to the present invention is a production method, wherein, in a step of extruding an internal phase comprising a fiber/film material and a good solvent for the fiber/film material in a linear form from the circular/rectangular end of the internal pipe of the apparatus into an external phase comprising a poor solvent for the fiber/film material, the external phase flowing in the external pipe of the apparatus, the ratio of the external phase flow rate to the internal phase flow rate is set to 1 or more, and further for the wet spun fibers, the external phase line speed at the orifice portion at which the internal phase and the external phase merge is set to 0.1 ms?1 or more.
    Type: Application
    Filed: September 30, 2019
    Publication date: May 19, 2022
    Applicant: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Tsutomu ONO, Takaichi WATANABE
  • Patent number: 11275128
    Abstract: Provided is a magnetic field measuring device which has good temperature stability and which enables an improvement by making it possible for the sensitivity of a Hall element, a magnetic impedance (MI) element or a magnetic resistance (MR) element, which are conventionally used extensively, to be set freely. This magnetic field measuring device comprises: a temperature maintaining means for maintaining an extremely low temperature state in which a superconductor adopts a superconducting state; a magnetic sensor which is provided inside the temperature maintaining means to detect a magnetic field; and a magnetic field space forming means for forming a magnetic field space specific to the superconducting state, by adopting a superconducting state inside the temperature maintaining means; wherein the magnetic sensor is disposed in the magnetic field space.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: March 15, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventor: Keiji Tsukada
  • Patent number: 11246948
    Abstract: An embodiment relates to a method of evaluating a lymphatic system function including: selecting one or a plurality of lymphatic routes to be evaluated from a plurality of lymphatic routes existing in four limbs; determining an injection site of a visualization agent based on information on the selected lymphatic route and injection sites of peripheries of the four limbs corresponding to the selected lymphatic route; injecting the visualization agent from the selected injection site; and visualizing the injected visualization agent and evaluating functions of the one or plurality of lymphatic routes to be evaluated.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: February 15, 2022
    Assignees: National University Corporation Okayama University, HAMAMATSU PHOTONICS K.K.
    Inventors: Akira Shinaoka, Yoshihiro Kimata, Aiji Ohtsuka, Takahiro Shikayama
  • Publication number: 20210401406
    Abstract: An ultrasonic diagnostic device according to an embodiment includes processing circuitry. The processing circuitry estimates a health state on the basis of a measurement value measured using ultrasonic image data. The processing circuitry determines an additional examination used to diagnose the health state, on the basis of the estimated health state. The processing circuitry outputs information indicative of the health state and the additional examination.
    Type: Application
    Filed: June 30, 2021
    Publication date: December 30, 2021
    Applicants: National University Corporation Okayama University, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Norihisa TOH, Kousuke NAMIKI, Koichiro KURITA
  • Publication number: 20210393715
    Abstract: In one embodiment, the present invention provides an anti-cancer-associated non-tumor cell agent. In one embodiment, the present invention relates to an anti-cancer-associated non-tumor cell agent comprising an oncolytic virus comprising a p53 gene. In one embodiment, the present invention relates to an anti-cancer-associated non-tumor cell preparation comprising a recombinant virus comprising: a first gene cassette containing a telomerase reverse transcriptase promoter, an E1A gene, an IRES sequence and an E1B gene; and a second gene cassette containing a promoter and a p53 gene.
    Type: Application
    Filed: June 21, 2021
    Publication date: December 23, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, Oncolys BioPharma Inc.
    Inventors: Toshiyoshi FUJIWARA, Toshihiro OGAWA, Takeyoshi NISHIYAMA, Satoru KIKUCHI, Hiroshi TAZAWA
  • Patent number: 11133505
    Abstract: The present disclosure relates to a positive electrode material for a lithium secondary battery which includes a positive electrode active material and a dielectric. The dielectric is a composite oxide represented by a general formula AmBnO? and has a dielectric constant of 10 to 500. Here, m and n are real numbers that satisfy 1.01?m/n?1.6, ? is a value that is determined so that charge neutral conditions are satisfied, A is one or more elements among alkali metal elements, alkaline earth metal elements, rare earth elements, Cu, Pb and Bi, and B is one or more elements among transition metal elements and Sn.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: September 28, 2021
    Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Daisuke Horikawa, Ryuta Sugiura, Takashi Teranishi
  • Publication number: 20210290598
    Abstract: Provided is a medicament useful for cardiovascular diseases. An agent for prevention and/or treatment of a cardiovascular diseases, comprising a combination of pemafibrate or a salt thereof and an HMG-CoA reductase inhibitor.
    Type: Application
    Filed: May 7, 2019
    Publication date: September 23, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, KOWA COMPANY, LTD.
    Inventors: Hiroshi ITO, Kazufumi NAKAMURA, Masatoki YOSHIDA, Keisuke INOUE
  • Patent number: 11103489
    Abstract: There is provided a drug for preventing or treating inflammatory bowel disease, comprising as an active ingredient an RXR agonist which is a compound represented by Formula (1). In Formula (1), it is preferred that: R1 is an alkyl group; R2 is an alkyl group; W is NR3, and R3 is an alkyl group; X1 is CH; Y1 is N; X2 and Y2 are CH; and Z is a carboxyl group. Thus, a drug capable of strongly preventing or treating inflammatory bowel disease while suppressing the onset of side effects is provided.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: August 31, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventor: Hiroki Kakuta
  • Patent number: 11096751
    Abstract: The invention may provide a puncture robot that can precisely move a needle in the puncture direction by setting needle position in a CT gantry. Provided is a puncture robot comprising a puncture unit, puncture robot being configured such that: the puncture unit comprises a puncture needle, an arm unit, a frame unit, and a base unit; the frame unit comprises a first frame and a second frame that are each provided with an advancing and retracting shaft, and a connecting rod; the arm unit comprises an upper arm and a lower arm, with the puncture needle being mounted to be parallel to the advancing and retracting shaft and the upper arm and the lower arm are advanced and retracted along the advancing and retracting shaft.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: August 24, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION, OKAYAMA UNIVERSITY
    Inventors: Hiroki Kitamura, Akira Heya, Takafumi Namba, Tetsushi Kamegawa, Takayuki Matsuno, Takao Hiraki
  • Publication number: 20210223229
    Abstract: The present invention relates to an immune function inspection method, comprising obtaining peripheral blood from a human test subject; applying an immunostimulant; inspecting changes in intracellular calcium ion concentration in peripheral blood mononuclear cells (PBMC) or CD8T cells; determining a decrease in systemic immune function when the intracellular calcium ion concentration in PBMC or CD8T cells transiently increases after the application of the immunostimulant and then returns to the state before the stimulation; and determining normality of systemic immune function when the intracellular calcium ion concentration in PBMC or CD8T cells is in an upward trend after the application of the immunostimulant.
    Type: Application
    Filed: February 10, 2017
    Publication date: July 22, 2021
    Applicant: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Heiichiro UDONO, Shingo EIKAWA
  • Patent number: 11026932
    Abstract: A method for treating an inflammatory respiratory disease, comprising administering an effective amount of an RXR agonist represented by formula (1) or (2) as an active ingredient. wherein D, R1, R2, X, Y, Z, R3, R4, X1, Y1, X2, Y2 and Z1 are defined.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: June 8, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Arihiko Kanehiro, Utako Fujii, Daisuke Morichika, Naohiro Oda, Nobuaki Miyahara, Akihiko Taniguchi, Hiroki Kakuta
  • Publication number: 20210164004
    Abstract: The present invention relates to a method including culturing a C1 compound-assimilating bacterium, which is a methylotroph, and/or a yeast by using a medium comprising, for example, a C1 compound and/or glycerol as a carbon source, to thereby produce EGT.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 3, 2021
    Applicant: National University Corporation Okayama University
    Inventor: Akio Tani
  • Publication number: 20210156797
    Abstract: A method is provided that allows the sulfur component concentration in gasoline to be estimated to high precision. The measuring method of the disclosure is a method of measuring the concentration of sulfur components in gasoline that contains sulfur components and aromatic components. The measuring method of the disclosure comprises: (A1) removing a portion of the gasoline by gasification to lower the proportion of the aromatic component concentration with respect to the sulfur component concentration in the gasoline, (A2) measuring values related to the refractive index of the gasoline, and (A3) measuring the sulfur component concentration in the gasoline based on the values related to the refractive index.
    Type: Application
    Filed: November 9, 2020
    Publication date: May 27, 2021
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, National University Corporation Okayama University
    Inventors: Akihiro HONDA, Hideki FUKANO
  • Patent number: 10987372
    Abstract: It is an object of the present invention to provide a novel therapeutic agent for hepatoma viruses. Specifically, the present invention relates to an anti-hepatoma virus agent, containing as an active ingredient a compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: (wherein R1 is fluorine or hydrogen).
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: April 27, 2021
    Assignees: KAGOSHIMA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, DAIKIN INDUSTRIES, LTD.
    Inventors: Masanori Ikeda, Midori Takeda, Masanori Baba, Nobuyuki Kato
  • Patent number: 10940210
    Abstract: The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: March 9, 2021
    Assignee: National University Corporation Okayama University
    Inventors: Hideki Matsui, Shuichi Furuya, Hiroyuki Michiue, Hiroki Kakuta, Yasuaki Takeuchi