Patents Assigned to National University Corporation Shiga University of Medical Science
  • Publication number: 20200246776
    Abstract: An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 ?mol and 2500 ?mol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 ?mol or less per 1 g.
    Type: Application
    Filed: September 7, 2018
    Publication date: August 6, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Junichi KASUYA, Ryo MATSUNAGA, Yoshiyuki UENO, Yuji UEDA, Kazuo TERAMOTO, Kazumasa OGASAWARA
  • Publication number: 20200215253
    Abstract: An objective of the present disclosure is to provide an adsorption material that can selectively adsorb immunosuppressive leukocyte. The present disclosure provides an adsorption material for immunosuppressive leukocyte. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae are bound. A form of the water-insoluble carrier is a fiber or a particle, a diameter of the fiber or the particle is 15 to 50 ?m, and an arithmetic mean roughness of a surface of the water-insoluble carrier is 0.1 to 3.0 ?m.
    Type: Application
    Filed: September 7, 2018
    Publication date: July 9, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Yoshiyuki UENO, Junichi KASUYA, Toru ARAKANE, Ryo MATSUNAGA, Yumiko SEKIYA, Yuji UEDA, Kazuo TERAMOTO, Kazumasa OGASAWARA
  • Patent number: 10166040
    Abstract: It is an object to provide a surgical tool for excising a hard solid organ such as cirrhotic liver or cutting the organ into a groove without causing bleeding. The inventors of the present invention have found that an organ resection tool including a brush-like structure capable of performing microwave irradiation and/or a brush-like structure capable of receiving a microwave can achieve the above-mentioned object, to thereby arrive at the present invention (organ resection tool including a brush structure capable of performing microwave irradiation). For example, an organ can be crushed or scraped away by manually abrading the organ with a brush of a solid organ resection tool including a brush structure capable of performing microwave irradiation according to the present invention. Further, the organ can be concurrently coagulated through the microwave irradiation to stop bleeding.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: January 1, 2019
    Assignee: National University Corporation Shiga University Of Medical Science
    Inventors: Tohru Tani, Shigeyuki Naka, Hiroya Akabori
  • Publication number: 20180340869
    Abstract: Provided are a cell-holding substrate holder for preparing an observation specimen, and a cell-holding substrate kit, wherein the cell-holding substrate can be easily attached and detached. Also provided is a method of preparing an observation specimen, wherein cell organelles can be satisfactorily observed using an optical microscope, while three problems of cell detachment, drying, and loss of the three-dimensional properties can be simultaneously solved. The cell-holding substrate holder comprises (1) a support plate 1 having a cell-holding substrate arrangement portion 12 having a window portion through which water can pass; and (2) a removable sandwiching plate 2, 3 which has a window portion through which water can pass, and is capable of working in conjunction with the support plate 1 to sandwich and fix a cell-holding substrate 9 in the cell-holding substrate arrangement portion 12. The cell-holding substrate kit 10 comprises the cell-holding substrate holder and a cell-holding substrate 9.
    Type: Application
    Filed: September 14, 2016
    Publication date: November 29, 2018
    Applicant: National University Corporation Shiga University of Medical Science
    Inventor: Ken-ichi MUKAISHO
  • Publication number: 20170290623
    Abstract: There is provided an energy device for surgical operation capable of suppressing fixation of body tissue, wherein a coating layer is formed on an outer periphery of a base material constituting an operational area portion transmitting energy in an energy device for surgical operation operating in the operational area portion, and is comprised of a base coating formed on the base material and an outermost coating formed on the base coating. The base coating is made from silicon oxide or a compound containing silicon oxide, and the outermost coating is made from polysiloxane or a compound containing polysiloxane or a compound containing a partly fluorinated polysiloxane, and the coating layer has a good adhesiveness and is applicable to a complicated form.
    Type: Application
    Filed: July 13, 2015
    Publication date: October 12, 2017
    Applicants: TOCALO CO., LTD., NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Shinya MIKI, Megumi ADACHI, Toru TANI, Shigeyuki NAKA, Tomoharu SHIMIZU
  • Patent number: 9289260
    Abstract: The solution of the problem to be solved is the provision of a means for determining timing both accurately and securely at which a treatment is shifted from gripping and coagulation (hemostasis or sealing) to resection by using a multifunctional treatment tool capable of exfoliation, gripping, coagulation (hemostasis or sealing) and resection of the treated region in a bipolar microwave treatment tool. A microwave surgical device control method and a device, in which the completion of coagulation (hemostasis or sealing) of tissue is detected and a microwave oscillation output is controlled by making use of the change in the direct current electric resistance value due to the reduction in the amount of water as the temperature rise of the tissue at the time of heating and coagulation of the tissue in the treated region with microwaves.
    Type: Grant
    Filed: March 25, 2008
    Date of Patent: March 22, 2016
    Assignee: NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Tohru Tani, Shigeyuki Naka
  • Publication number: 20140358165
    Abstract: Provided is a surgical instrument that is substitutable for an operation of placing each stitch with a threaded needle or a stapler. It is confirmed that, in a tissue suturing device including a clamping section, and a protruding section including a central conductor and/or an external conductor for applying a microwave, the protruding section and the clamping section bring fragmentary portions of tissues to be sutured into contact or overlap with each other, and coagulate and/or fix contact or overlap portions with the microwave, to thereby stitch the tissues to be sutured.
    Type: Application
    Filed: December 14, 2012
    Publication date: December 4, 2014
    Applicant: NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Tohru Tani, Shigeyuki Naka
  • Publication number: 20140194865
    Abstract: It is an object to provide a surgical instrument capable of locally applying microwaves to a minute biological tissue. It has been found that microwaves can be transmitted to a tip of a tapered coaxial body (9) and that microwaves are radiated from the entire central conductor exposed in a major axis direction by decreasing a sectional area (preferably diameter) of a central conductor (1) and a sectional area (preferably inner diameter) of an external conductor gradually or in a step-by-step manner with a ratio between the sectional area (diameter) of the central conductor (1) and the sectional area (inner diameter) of the external conductor being set to be constant, thereby achieving the present invention.
    Type: Application
    Filed: August 9, 2012
    Publication date: July 10, 2014
    Applicant: NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Tohru Tani, Shigeyuki Naka, Hisanori Shiomi
  • Patent number: 8313483
    Abstract: Provided is an operating tool for organism, in particular, a microwave endoscope forceps. In terms of the operating tool for organism, provided is a multifunctional operating tool which has holding and scissors functions simultaneously, and may further perform coagulation (tissue fixation) by microwaves. The operating tool has no definite fulcrum, and has both the holding and scissors functions with a simple structure by deforming a long-track rod called beam. Two blades are insulated from each other so as to allow microwave current supply. With this structure, an operating tool having three functions, i.e., “a holding function”, “a coagulating function”, and “a cutting function” with a single tool may be developed.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: November 20, 2012
    Assignee: National University Corporation Shiga University of Medical Science
    Inventors: Makoto Hosaka, Tohru Tani, Yoshimasa Kurumi, Shigeyuki Naka
  • Publication number: 20100023001
    Abstract: Provided is an operating tool for organism, in particular, a microwave endoscope forceps. In terms of the operating tool for organism, provided is a multifunctional operating tool which has holding and scissors functions simultaneously, and may further perform coagulation (tissue fixation) by microwaves. The operating tool has no definite fulcrum, and has both the holding and scissors functions with a simple structure by deforming a long-track rod called beam. Two blades are insulated from each other so as to allow microwave current supply. With this structure, an operating tool having three functions, i.e., “a holding function”, “a coagulating function”, and “a cutting function” with a single tool may be developed.
    Type: Application
    Filed: November 8, 2007
    Publication date: January 28, 2010
    Applicant: National University Corporation Shiga University of Medical Science
    Inventors: Makoto Hosaka, Tohru Tani, Yoshimasa Kurumi, Shigeyuki Naka
  • Patent number: 7582427
    Abstract: An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation(s) in a gene coding for UGT. A gene coding for UGT comprises 5 exons, and since the regions of exons 2 through 5 are common to each isoform of UGT1, by assaying a mutation in the common regions, particularly a mutation in exon 5 region, and further adding the detection of (a) mutation(s) in a plurality of exon regions, mutations of UGT1 gene can effectively assayed. A nucleic acid chip using nucleic acid probes is used as a way of detecting (a) mutation(s).
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: September 1, 2009
    Assignee: National University Corporation Shiga University of Medical Science
    Inventors: Hiroshi Sato, Yoshihide Fujiyama, Kazuo Yamamoto