Patents Assigned to National Yang-Ming University
  • Methods for modulating the expression and aggregation of CAG-expanded gene product in cells and methods for identifying agents useful for doing the same
    Patent number: 8569254
    Abstract: This invention provides a method for modulating the expression of a first gene in a cell wherein the first gene is one containing more than 36 CAG trinucleotide repeats and encoding a protein that form polyglutamine-mediated protein aggregation. Suppression of the first gene is achieved by reducing the expression of SPT4 gene or SUPT4H gene. It can also be achieved by inhibiting the formation of a Spt4/Spt5 complex or a Supt4h/Supt5h complex. Also provided is a method for identifying an agent useful for modulating the expression and aggregation of CAG-expanded gene product, or treating a polyglutamine disease such as Huntington's disease.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: October 29, 2013
    Assignee: National Yang Ming University
    Inventors: Tzu-Hao Cheng, Chia-Rung Lu, Tzu-Han Wang, Stanley N. Cohen
  • Estimation of pressure at remote site by brachial oscillometric waveform analysis
    Patent number: 8568440
    Abstract: The present invention relates to a device and a method for estimating central systolic blood pressure based on oscillometric signals from brachial artery by the use of a pressure cuff.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: October 29, 2013
    Assignee: National Yang-Ming University
    Inventors: Chen-Huan Chen, Hao-Mim Cheng
  • METHODS AND SYSTEM FOR ULTRASOUND-MEDIATED DRUG DELIVERY
    Publication number: 20130261442
    Abstract: The present invention provides an ultrasound-mediated drug delivery method for administering a compound to a targeted tissue, and the method at least comprises the following steps: First, an ultrasound apparatus is provided. The compound is then administered to the targeted tissue. A sonication is performed by the ultrasound apparatus to a blood vessel of the targeted tissue after the administration of the compound, and the sonication is capable of enhancing the permeability of the blood vessel to allow the administration of the compound to the targeted tissue. An ultrasound-mediated drug delivery system is also disclosed here.
    Type: Application
    Filed: December 27, 2012
    Publication date: October 3, 2013
    Applicant: NATIONAL YANG MING UNIVERSITY
    Inventor: Feng-Yi YANG
  • ULTRASONIC POSITIONING DEVICE FOR EPIDURAL SPACE AND METHOD USING THE SAME
    Publication number: 20130204133
    Abstract: An ultrasonic positioning method for real time measuring the distance between the epidural needle and the epidural space is provided. The ultrasonic positioning method at least includes a puncturing step; an advancing step; a positioning step for simultaneous detecting reflected ultrasonic signals from the ligamentum flavum (LF) and dura mater (DM); a replacement step for removing the ultrasound needle transducer and putting an injecting catheter; and an injection step for injecting an anesthetic into the epidural space via the injecting catheter.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 8, 2013
    Applicant: NATIONAL YANG-MING UNIVERSITY
    Inventor: National Yang-Ming University
  • Walking assistance device with detection members
    Patent number: 8500143
    Abstract: The present invention relates to a walking assistance device with detection function, which includes a movable frame, a power transmission device mounted under the frame, a detachable power unit mounted on the frame, at least one signal transmitter and at least one signal receiver for detecting the distances from a first portion and a second portion on the user's body to a correspond position of the frame respectively. According to the distances detected, a control unit sends signals to the power transmission device to maintain the distance between the user and the frame within a preset range, therefore to provide supporting forces when the user needs.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: August 6, 2013
    Assignee: National Yang-Ming University
    Inventors: Chung-huang Yu, Chih-wei Chien
  • Compositions And Method For Detecting And Treating Abnormal Liver Homeostasis And Hepatocarcinogenesis
    Publication number: 20130142861
    Abstract: Novel compositions and methods for detecting and preventing and/or treating abnormal liver homeostasis and hepatocarcinoma as well as conditions that may be regulated by microRNA-122 are provided. A transgenic knockout non-human animal comprising a disruption in the endogenous mir-122 gene is also provided.
    Type: Application
    Filed: November 29, 2012
    Publication date: June 6, 2013
    Applicant: NATIONAL YANG MING UNIVERSITY
    Inventor: National Yang Ming University
  • Method and system of auditory evoked heart rate variability analysis
    Patent number: 8452385
    Abstract: The present invention provides a method and system of auditory evoked heart rate variability analysis having advantage of simply analytical process and portability. The disclosed method mainly includes the following steps of: stimulating the auditory system of a person by a sound through a sound transmission device, capturing an electrocardiogram signal of the person, performing analog-to-digital conversion of the electrocardiogram signal, selecting the peaks of the electrocardiogram signal and transforming the qualified peaks to a consecutive peak signal, and performing spectrum analysis to the peak signal in frequency domain, and obtaining the difference of the spectral parameters before and after the evoked sounds. Moreover, the sound further is selected from the group consisting of noise, short tone burst, click, and any other sound with the intensity of 30 dB to 100 dB.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: May 28, 2013
    Assignee: National Yang-Ming University
    Inventors: Guo-She Lee, Bo-Jau Kuo
  • Methods And Compositions For The Treatment And Prevention Of Aging-Associated Conditions
    Publication number: 20130122082
    Abstract: The present disclosure provides novel compositions and therapeutics and their methods of use. In particular, it relates to novel compositions and therapeutics expressing the Cisd2 gene and increasing Cisd2 protein activity as well as methods of using the compositions and therapeutics for treating or preventing aging-associated conditions.
    Type: Application
    Filed: November 3, 2012
    Publication date: May 16, 2013
    Applicant: NATIONAL YANG MING UNIVERSITY
    Inventor: National Yang Ming University
  • ANASTOMOSIS SYSTEM
    Publication number: 20130110140
    Abstract: An anastomosis system includes a base, two rings, and a blood vessel-leading unit. A first blood vessel can be inserted in and attached to the first ring by the blood vessel-leading unit. A second blood vessel can be inserted in and attached to the second ring by the blood vessel-leading unit. The first ring is placed on a ring-guiding base in a specific manner. The second ring is placed on the ring-guiding base in a movable and rotatable manner to assure the alignment of the blood vessels in both axial and angular directions. The two rings are interconnected by at least one snap-on mechanism or buckle so that the interconnection of the rings is efficient.
    Type: Application
    Filed: December 18, 2012
    Publication date: May 2, 2013
    Applicant: NATIONAL YANG-MING UNIVERSITY
    Inventor: NATIONAL YANG-MING UNIVERSITY
  • Method and apparatus for brain perfusion magnetic resonance images
    Patent number: 8427151
    Abstract: The present invention discloses a method and apparatus for brain perfusion magnetic resonance imaging (MRI) technique with the removal of cerebrospinal fluid (CSF) pixels. This invention utilizes a CSF/brain-contrast-enhanced image, wherein the CSF/brain-contrast-enhanced image is defined as the signal difference between CSF and brain matter divided by a standard deviation of air background random noise is larger than 3, acquired from the subject's brain, and applies a segmentation technique to remove the CSF pixels. After removing the CSF pixels on parametric images, the extent of brain tissue with delayed perfusion can be better identified. By using a good region of interest enclosing the correct delayed-perfusion region, the measurement on the tissue volume and perfusion parameters would be more accurate than the area contaminated by CSF pixels.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: April 23, 2013
    Assignee: National Yang-Ming University
    Inventors: Yi-Hsuan Kao, Mu-Huo Teng, Wen-Yan Zheng, Yu-Fen Chen
  • Biologically active extract from plant, use thereof and process for preparing the same
    Patent number: 8426371
    Abstract: A substance having the following formula is provided. wherein R1 and R2 are selected from a group consisting of ?-Arabinose, ?-Arabinose and ?-Xylose. The substance has an effect of accelerating a phagocytosis of RPE.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: April 23, 2013
    Assignee: National Yang-Ming University
    Inventor: Rong-Tsun Wu
  • Transfection with micro explosion enacted by coated dry ice particles
    Patent number: 8415160
    Abstract: Disclosed is a transfection method, which includes the steps of: (a) adhering the gene fragments to dry ice particles; (b) adding the dry ice particles into the medium/liquid that contains target cells; and (c) transporting the gene fragments into the target cells via the micro explosion/sublimation of the dry ice particles. In addition, the gene fragments can also adhere first to nanoparticles, which can then adhere to dry ice particles. Subsequently, gene fragments enter cells by micro explosion/sublimation. The present invention can be applied in transgenic research on prokaryotic, eukaryotic, plant and animal cells and in the development of new species in agriculture.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: April 9, 2013
    Assignee: National Yang Ming University
    Inventors: Fu-Jen Kao, Yung-En Kuo
  • Head-mounted visual display device with stereo vision and its system
    Patent number: 8350898
    Abstract: A head-mounted visual display device for low-vision aid, which features 2 models, they are analog signal model and digital signal model. Said analog device contains at least an analog video extractor, a video decoder, an ITU-R.656 decoder, a de-interlacing unit, an image processor, two YCbCr to RGB converter, two color enhancement units, two video D/A converter, a head mounted display, a signal voltage controller and a wireless communication module. Said digital device consists of a digital video signal extractor/capturer, a RGB to YCbCr converter, an image processor, two YCbCr to RGB converter, two color enforcement units, a head-mounted display, a signal voltage controller and a wireless communication module.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: January 8, 2013
    Assignee: National Yang-Ming University
    Inventors: Yin Chang, Yen-Liung Lai, Ji-Min Li, Yu-Wei Du
  • ANTI-NPC2 MONOCLONAL ANTIBODIES AND A METHOD OF DETECTING FATTY LIVER TISSUE, CANCER CELLS OR CANCER TISSUE BY USING THEM
    Publication number: 20120315644
    Abstract: The present invention is related to anti-NPC2 monoclonal antibodies, which against NPC2 or glycosylated-NPC2; and is related to a method of detecting fatty liver tissues, cancer cells or cancer tissues by evaluating the expression level of NPC2 or glycosylated-NPC2 in the cells or tissues.
    Type: Application
    Filed: September 22, 2011
    Publication date: December 13, 2012
    Applicant: NATIONAL YANG MING UNIVERSITY
    Inventors: Yi-Ming CHEN, Kuan-Hsuan CHEN
  • ESTIMATION OF PRESSURE AT REMOTE SITE BY BRACHIAL OSCILLOMETRIC WAVEFORM ANALYSIS
    Publication number: 20120289840
    Abstract: The present invention relates to a device and a method for estimating central systolic blood pressure based on oscillometric signals from brachial artery by the use of a pressure cuff.
    Type: Application
    Filed: March 15, 2012
    Publication date: November 15, 2012
    Applicant: NATIONAL YANG-MING UNIVERSITY
    Inventors: CHEN-HUAN CHEN, HAO-MIM CHENG
  • GLYCINE N-METHYLTRANSFERASE (GNMT) ANIMAL MODEL AND USE THEREOF
    Publication number: 20120270227
    Abstract: The present invention is a method of detecting abnormality of liver in a subject, comprising: (i) measuring expression level of genes consisting of survival and proliferation genes, oncogenes, tumor suppressor genes, one carbon metabolism genes and glycogen storage disease related genes, and (ii) determining expression level of genes are indicative of abnormality of liver function when expression level of the survival and proliferation genes and the oncogenes in sample are higher than in wild-type; and expression level of the tumor suppressor genes, the one carbon metabolism genes, and the glycogen storage disease related genes in sample is lower than in wild-type.
    Type: Application
    Filed: July 3, 2012
    Publication date: October 25, 2012
    Applicant: NATIONAL YANG-MING UNIVERSITY
    Inventors: YI-MING CHEN, SHIH-PING LIU
  • Sleep analysis system and method for analyzing sleep thereof
    Patent number: 8292819
    Abstract: The invention provides a sleep analysis system and a method for analysis thereof. The sleep analysis system includes an analysis device and a sleep sensing apparatus. The sleep sensing apparatus includes an ECG signal collector, a multi-axial accelerometer, a wireless transmitting unit, and a control unit. The ECG signal collector is used for collecting an ECG signal associated with a subject. The multi-axial accelerometer is used for detecting a multi-axial accelerometer signal associated with the subject. The control unit controls the wireless transmitting unit to transmit the ECG signal and the multi-axial accelerometer signal to the analysis device for analyzing sleep of the subject.
    Type: Grant
    Filed: March 23, 2009
    Date of Patent: October 23, 2012
    Assignee: National Yang-Ming University
    Inventors: Bo-Jau Kuo, Ching-Hsiu Yang
  • ANTI-CANCER EXTRACT AND COMPOUNDS
    Publication number: 20120259004
    Abstract: The preset invention relates to a new approach for treating a cancer or fibrosis, such as Hepatocellular carcinoma, or liver fibrosis using an extract from a plant of Graptopetalum sp., Rhodiola sp. or Echeveria sp., and prepared by extracting the plant with Dimethyl sulfoxide (DMSO), its fraction or the compound isolated from the extract.
    Type: Application
    Filed: September 30, 2011
    Publication date: October 11, 2012
    Applicant: National Yang-Ming University
    Inventor: Chi-Ying Huang
  • Oven with light emitting diode and/or laser diode as heating devices
    Patent number: 8238732
    Abstract: The present invention provides an oven that utilizes light emitting diode (LED) and or laser diode (LD) as heating devices. Such heating devices will enable a wide variety of heating modalities.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: August 7, 2012
    Assignee: National Yang-Ming University
    Inventors: Fu-Jen Kao, Yi-Cheng Lin
  • RADIOLABELED NUCLEOSIDE ANALOGUE, AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20120178919
    Abstract: A radiolabeled nucleoside analogue is provided, which includes radioactive iodine 123I/131I, and a nucleoside analogue selected from a group consisting of cytidine, thymidine, uridine, and a derivative thereof. A method for preparing the radiolabeled nucleoside analogue, and a use thereof are further provided. The nucleoside analogue, prepared through the preparation method with a short synthesis time and a high radiochemical yield, has a long in vivo physiological half life and a high stability in serum, and, as a radiopharmaceutical composition, is useful in development of tumor proliferation diagnosis or therapy prognosis evaluation, and further assists in observation of long-time in vivo metabolism of a drug.
    Type: Application
    Filed: July 29, 2011
    Publication date: July 12, 2012
    Applicants: NATIONAL YANG-MING UNIVERSITY, Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
    Inventors: HSIN-ELL WANG, CHIH-YUAN LIN, WEI-TI KUO, CHUAN-LIN CHEN, MEI-HUI WANG, HUNG-MAN YU, MAO-CHI WENG, YU CHANG, WUU-JYH LIN