Patents Assigned to Nationwide Children's Hospital
  • Transcutaneous vaccine formulations and methods
    Patent number: 10722568
    Abstract: Provided are topical delivery systems and methods for treating and/or preventing a disease or disorder in a subject, or for eliciting an immune response in a subject including applying, to at least a portion of the subject's post-auricular region, a topical delivery system including a therapeutically effective amount of a topical pharmaceutical composition comprising at least one active agent and a pharmaceutically acceptable carrier and/or adjuvant. The topical pharmaceutical composition can include a topical immunogenic composition. The topical delivery system can further include a flexible substrate in communication with the topical immunogenic composition. The subject can be a pediatric subject.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: July 28, 2020
    Assignee: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
    Inventor: Lauren O. Bakaletz
  • Proteomics based diagnostic detection method for chronic sinusitis
    Patent number: 10725040
    Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: July 28, 2020
    Assignees: NATIONWIDE CHILDREN'S HOSPITAL, INC., THE OHIO STATE UNIVERSITY
    Inventors: Subinoy Das, Lauren O. Bakaletz
  • PROBIOTIC FORMULATIONS AND METHODS FOR USE
    Publication number: 20200155620
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Application
    Filed: June 21, 2019
    Publication date: May 21, 2020
    Applicants: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
  • ENHANCED MODIFIED VIRAL CAPSID PROTEINS
    Publication number: 20200157570
    Abstract: Modified capsid proteins, isolated polynucleotides, methods for the preparation of modified capsid proteins, recombinant viral particles, recombinant expression systems for the generation of modified viral particles, and methods of gene editing and regulation are provided herein.
    Type: Application
    Filed: June 4, 2018
    Publication date: May 21, 2020
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventor: Scott Allen LOILER
  • Medical testing apparatus and method of use
    Patent number: 10653354
    Abstract: A medical testing apparatus and method of use for for penetrating a patient's tissue with an agent, the apparatus comprises an arcuate rail having spaced first and second sides supported by upper and lower arcuate surfaces and an arcuate handle having first and second ends extending from the upper surface of the arcuate rail. A plurality of tips extend substantially from and normally outward as the lower arcuate surface. The plurality of tips comprises alternating blunt tips and reed tips.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 19, 2020
    Assignees: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Amber M. Patterson, Benjamin A. Patterson, Jay A. Shepherd, Meagan W. Shepherd
  • Prebiotic formulations
    Patent number: 10624934
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: April 21, 2020
    Assignees: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
  • Compositions and methods for the removal of biofilms
    Patent number: 10595530
    Abstract: Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more HMG-box domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: March 24, 2020
    Assignees: Nationwide Children's Hospital, Inc., University of Southern California
    Inventors: Steven D. Goodman, Lauren O. Bakaletz
  • Portable image diagnostic apparatus and system
    Patent number: 10571782
    Abstract: An apparatus and system for analyzing one or more points of interest. The apparatus includes a main support having first and second legs. The first and second legs extending transversely from the main support. The main support nests an imaging device capable of capturing an image of a point of interest during use. An imaging shroud is coupled to and extending from the first leg, the shroud having a first opening for surrounding the point of interest. A second opening in the shroud is positioned such that it extends to be within the main support for the passage of a captured image of the point of interest during use.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: February 25, 2020
    Assignee: Research Institute at Nationwide Children's Hospital
    Inventors: Robert V. Strouse, Jeremy Patterson, Kara Rood, Irina Buhimschi
  • STEM LOOP RNA MEDIATED TRANSPORT OF MITOCHONDRIA GENOME EDITING MOLECULES (ENDONUCLEASES) INTO THE MITOCHONDRIA
    Publication number: 20200032251
    Abstract: The present disclosure relates to a novel CRISPR-Cas9 based system for editing mitochondrial DNA. Aspects of the disclosure provide for mitochondrial translocation of both the guide RNA and the recombinant Cas9 nuclease.
    Type: Application
    Filed: November 15, 2017
    Publication date: January 30, 2020
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Kenneth John McLaughlin, Syed-Rehan Ashfaq Hussain
  • Compositions and methods for the removal of biofilms
    Publication number: 20200002409
    Abstract: This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
    Type: Application
    Filed: August 16, 2018
    Publication date: January 2, 2020
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Steven D. Goodman, Lauren O. Bakaletz
  • NOVEL FORMULATION FOR THE ELIMINATION OF CARIOGENIC AND OPPORTUNISTIC PATHOGENS WITHIN THE ORAL CAVITY
    Publication number: 20190388309
    Abstract: Provided herein are microspheres containing an antimicrobial agent encapsulated within a glycosidic polymer and use thereof, especially to inhibit the growth of carie-causing organism.
    Type: Application
    Filed: June 11, 2019
    Publication date: December 26, 2019
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Steven David Goodman, Lauren Mashburn Warren
  • ANTIBODY FRAGMENTS FOR THE TREATMENT OF BIOFILM-RELATED DISORDERS
    Publication number: 20190338018
    Abstract: This disclosure provides antibody fragments and isolated polypeptides comprising the antibody fragments that are useful as a therapeutic for those with an existing infection characterized by the formation of biofilms. Antibody fragments and isolated polypeptides comprising the antibody fragments can be administered to detect, treat, or prevent infection and/or remediate biofilms. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
    Type: Application
    Filed: January 3, 2018
    Publication date: November 7, 2019
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Lauren O. Bakaletz, Steven D. Goodman
  • DNABII VACCINES AND ANTIBODIES WITH ENHANCED ACTIVITY
    Publication number: 20190337996
    Abstract: The disclosure provides methods and compositions that are useful to lessen and/or cure bacterial biofilms and treat diseases or disorders associated with biofilms using one or more novel polypeptide vaccines, antibodies, antibody fragments and compositions. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
    Type: Application
    Filed: January 3, 2018
    Publication date: November 7, 2019
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Lauren O. Bakaletz, Steven D. Goodman
  • Modulation of alternative MDM2 splicing
    Patent number: 10465193
    Abstract: Compositions and methods for treating cancer in a subject in need thereof are described that includes administering a therapeutically effective amount of an oligonucleotide that inhibits the binding of splicing regulator SRSF1 or SRSF2 to MDM2 exon 4 or 11.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: November 5, 2019
    Assignee: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
    Inventors: Dawn Suzan Chandler, Daniel Forrest Comiskey, Jr.
  • Live attenuated vaccines for pneumoviruses and related methods and materials
    Patent number: 10465170
    Abstract: Described herein are mutant pneumoviruses comprising a nucleotide sequence which encodes a mutated zinc binding motif in an M2-1 protein of the pneumovirus, wherein the zinc binding motif is mutated relative to wild-type pneumovirus. The mutant pneumoviruses described herein grow to high titer in cell culture, are genetically stable, are attenuated in vitro and in vivo, and are highly immunogenic. Also described herein are vaccines and vaccine compositions comprising the live attenuated mutant pneumoviruses. Vaccine compositions can further comprise a pharmaceutically acceptable carrier, vehicle, excipient, and/or adjuvant. Methods for inducing a protective immune response in a subject against a pneumovirus infection are also described and disclosed.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: November 5, 2019
    Assignees: Ohio State Innovation Foundation, Research Institute at Nationwide Children's Hospital
    Inventors: Mark E. Peeples, Jianrong Li, Hui Cai, Rongzhang Wang
  • Methods and devices for optimizing magnetic resonance imaging protocols
    Patent number: 10444311
    Abstract: Techniques for optimizing a magnetic resonance imaging (MRI) protocols are described herein. An example method can include receiving one or more MRI scanner settings for an imaging sequence; selecting at least one objective function from a plurality of objective functions; selecting an acquisition train length; selecting a k-space strategy; selecting one or more imaging parameters; and acquiring a magnetic resonance (MR) image using at least one of an optimized k-space strategy, an optimized acquisition train length, or optimized imaging parameters.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: October 15, 2019
    Assignees: Ohio State Innovation Foundation, Research Institute at Nationwide Children's Hospital
    Inventors: Jinghua Wang, Zhong-lin Lu, Nehal Parikh, Lili He
  • Probiotic formulations and methods for use
    Patent number: 10369176
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: August 6, 2019
    Assignees: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
  • Methods and compositions for treating disorders and diseases using Survival Motor Neuron (SMN) protein
    Patent number: 10357543
    Abstract: Disclosed are methods and compositions related to treatment and prevention of sarcopenia and/or nerve injury by increasing survival motor neuron (SMN) levels in an individual in need thereof.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: July 23, 2019
    Assignees: Ohio State Innovation Foundation, The Research Institute At Nationwide Children's Hospital
    Inventors: Arthur Burghes, William Arnold, Brian Kaspar, Vicki McGovern
  • Proteomics based diagnostic detection method for chronic sinusitis
    Patent number: 10345300
    Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: July 9, 2019
    Assignees: NATIONWIDE CHILDREN'S HOSPITAL, INC., THE OHIO STATE UNIVERSITY
    Inventors: Subinoy Das, Lauren O. Bakaletz
  • Recombinant virus products and methods for inhibition of expression of DUX4
    Patent number: 10301649
    Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: May 28, 2019
    Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.
    Inventors: Scott Quenton Harper, Jian Liu, Sara Coppens, Lindsay Wallace