Abstract: Derivatives of azadirachtin are described which should facilitate their synthesis and provide greater stability than their naturally-occurring counterpart. The derivative 2',3',22,23-tetrahydorazadirachtin is also described, that derivative retaining full activity and having enhanced stability. Also described is a newly identified, naturally occurring derivative of azadirachtin, 1-cinnamoylmelianolone, and several of its derivatives. Insecticidal and antifeedant compositions including these compounds, and processes for their use, are also described.