Abstract: Disclosed herein are systems and methods for providing a portable magnetic field therapy system for treatment of diseases and adverse health conditions, such as cancer.

Abstract: A method and apparatus for producing an effect of a chemical or biochemical agent on a system responsive to such agent, are disclosed. In practicing the method, a plurality of low-frequency time-domain signals of the agent are generated, each at a different at a different noise level within a selected noise level range. The signals are analyzed by producing spectral plots of the time-domain signals, and identifying an optimized agent-specific time-domain signal based on information in the spectral plots. A chemical or biological system responsive to the agent is exposed to the optimized time-domain signal by placing the system within the magnetic field of an electromagnetic transducer, and applying the signal to the transducer at a signal amplitude and for a period sufficient to produce in the system an agent-specific effect on the system.

Abstract: A storage medium having a low frequency time-domain signal stored thereon, and methods of generating, scoring, testing and using the signals are disclosed. In one general embodiment, the signal is derived from a taxane-like compound or an siRNA against human GADPH, and is useful in treating cancer in a subject by exposing the subject a low-magnetic field transduction of the signal. Also disclosed are improved signal transduction methods.

Abstract: A method and apparatus for producing an effect of a chemical or biochemical agent on a system responsive to such agent, are disclosed. In practicing the method, a plurality of low-frequency time-domain signals of the agent are generated, each at a different at a different noise level within a selected noise level range. The signals are analyzed by producing spectral plots of the time-domain signals, and identifying an optimized agent-specific time-domain signal based on information in the spectral plots. A chemical or biological system responsive to the agent is exposed to the optimized time-domain signal by placing the system within the magnetic field of an electromagnetic transducer, and applying the signal to the transducer at a signal amplitude and for a period sufficient to produce in the system an agent-specific effect on the system.

Abstract: A method of forming an aqueous composition effective to produce an agent-specific effect on an agent-responsive chemical or biological system, when the composition is added to the system, is disclosed. The composition is formed by exposing an aqueous medium to a low-frequency, time-domain signal derived from the agent, until the aqueous medium acquires a detectable agent activity. Exemplary compositions are formed by exposure to a paclitaxel signal or a signal derived from a therapeutic oligonucleotide, such as GAPDH antisense RNA and PCSK9 antisense RNA. Also disclosed are methods for confirming the activity of the composition, and for preparing and testing the activity of the compositions.

Abstract: Compositions and methods relating to magnetic particles comprising one or more fluorescence detectable moieties positioned asymmetrically with respect to the magnetic pole regions of the particles are described. The compositions are useful for detecting analytes.

Abstract: Method and apparatus for detecting a selected material in a sample are disclosed. In the method, the sample is placed adjacent a detector coil, for generating an electromagnetic time-domain signal composed of sample source radiation. The signal is first conditioned to convert the signal to an amplified conditioned signal from which frequency components above a selected frequency have been removed, then filtered to selectively pass low-frequency spectral components that are (i) in a frequency range between dc and 50 khz, and (ii) characteristic of the selected material. The filtered signal is cross-correlated with a data set of low-frequency spectral components that are (i) in a frequency range between dc and 50 khz, and (ii) characteristic of a selected material, to produce a frequency-domain spectrum in the frequency range within DC to 50 khz.

Abstract: Methods and apparatus inject noise into a substance, detect the combination of the noise and the signal emitted by the substance, adjust the noise until the combination signal takes on the characteristic of the signal generated by the substance through stochastic resonance, and apply such characteristic signals to responsive chemical, biochemical, or biological systems. The generated signal may be stored, manipulated, and/or transmitted to a remote receiver.

Abstract: A method and apparatus for interrogating a sample that exhibits molecular rotation are disclosed. In practicing the method, the sample is placed in a container having both magnetic and electromagnetic shielding, and Gaussian noise is injected into the sample. An electromagnetic time-domain signal composed of sample source radiation superimposed on the injected Guassian noise is detected, and this signal is cross-correlated with a second time-domain signal produced by the same or similar sample, to produce a cross-correlated signal with frequency domain components. The latter is plotted in the frequency domain by a fast Fourier transform to produce a frequency domain spectrum in a frequency range within DC to 50 KHz. From this spectrum, one or more low-frequency signal components that are characteristic of the sample being interrogated are identified.