Abstract: Provided herein are methods and compositions for Asparagus racemosus and Withania somnifera in treating the quality of life, improving endothelial function and biomarkers, bone health biomarkers, and bone mineral density (BMD) in postmenopausal women.

Abstract: Methods of relieving back pain with Terminalia chebula compositions are described.

Abstract: The present invention is directed to methods of treating cancer and inhibiting proliferation of cancer cells with compositions comprising extracts prepared from Terminalia chebula fruits (for instance AyuFlex®), Terminalia bellerica fruits (for instance Ayuric®), Phyllanthus emblica fruits (for instance Capros®), Withania somnifera roots and leaves (for instance Sensoril®), Shilajit (for instance PrimaVie®), Azadirachta indica leaves and twigs (for instance PhytoBGS®), and/or combinations thereof, including a trivalent chromium complex with extracts of Shilajit and P. emblica (e.g. Crominex-3+®). Combinations of the extracts with anti-cancer drugs, and related methods, are also described.

Abstract: This invention is directed to methods of attenuating brain injury and providing neuroprotection to the brain from injury such as from stroke, by administering compositions containing extracts of Phyllanthus emblica; and related methods.

Abstract: This invention is directed to compositions comprising dibenzo-alpha-pyrones (DBPs, Urolithins) and DBP glycosides, and methods of improving the immune system, providing immuno-protection, and/or treating immunosuppression in a subject with the compositions. The compounds 3-OH-DBP (Urolithin B), 3,8-(OH)2-DBP (Urolithin A), and their glycosides are discussed.

Abstract: This invention is directed to methods of treating and/or preventing hepatotoxicity and providing hepatoprotection in a subject with dibenzo-alpha-pyrones (DBPs), including 3-OH-DBP (Urolithin B), 3,8-(OH)2-DBP (Urolithin A), and synergistic combinations of the two DBPs.

Abstract: This disclosure is directed to methods of treating, preventing, and protecting against viral infection including coronavirus infection and symptoms such as in COVID-19 infection. The methods include the administration of a composition comprising an extract and/or extract component, specifically, plant and/or herbo-mineral extracts, such as of Shilajit, Withania somnifera, Asparagus racemosus, Terminalia chebula, Terminaha bellirica, Phyllanthus emblica, Azadirachta indica, and a trivalent chromium complex with extracts of P. emblica and Shilajit; and/or extract components such as 3,8-dihydroxy-6H-benzo[c]chromen-6-one and 3-hydroxy-6H-benzo[c]chromen-6-one.

Abstract: The present invention is directed to methods of treating cancer and inhibiting proliferation of cancer cells with compositions comprising extracts prepared from Terminalia chebula fruits (for instance AyuFlex®), Terminalia bellerica fruits (for instance Ayuric®), Phyllanthus emblica fruits (for instance Capros®), Withania somnifera roots and leaves (for instance Sensoril®), Shilajit (for instance PrimaVie®), Azadirachta indica leaves and twigs (for instance PhytoBGS®), and/or combinations thereof, including a trivalent chromium complex with extracts of Shilajit and P. emblica (e.g. Crominex-3+®). Combinations of the extracts with anti-cancer drugs, and related methods, are also described.

Abstract: The present invention is directed to methods of increasing muscular strength and muscular endurance with a combination of the administration of Asparagus racemosus to a subject and resistance training of the subject's body.

Abstract: Methods of using Shilajit or its individual components, or a combination of two or more of these components, to improve skin microperfusion, to upregulate ECM related genes in the skin, to increase endothelial cell migration and growth of blood vessels, and thus to improve skin health are presented herein.

Abstract: The present invention is directed to methods for improving muscle and connective tissue with Shilajit, including reducing collagen degradation and reducing the loss of strength due to muscle fatigue. The present methods improve muscle building and repair as well as the health of skin, cartilage, connective tissues, muscle, vascular tissues, bones, and teeth, and treat collagen-related disorders such as arthritis and osteoporosis.

Abstract: A synergistic combination of Urolithin A (3,8-dihydroxy-dibenzo-alpha-pyrone) and Urolithin B (3-hydroxy-dibenzo-alpha-pyrone) is provided in a particular effective ratio, optionally in a nutraceutical or pharmaceutical composition. The composition is for use in treating cognitive deficits, including increasing cognitive function or cognitive capacity (nootropic activity). The composition is for use in treating or preventing a dementia-related disorder in a human subject, such as anxiety or Alzheimer's disease, and for inhibition of acetylcholinesterase (AChE).

Abstract: Methods of treating symptoms of type 2 diabetes in a human subject by administering a composition comprising urolithin A and urolithin B, are provided. Methods of treating symptoms of type 2 diabetes and metabolic syndrome in a human subject by administering a composition comprising neem extract are provided.

Abstract: Methods of using Shilajit or its individual components, or a combination of two or more of these components, to improve skin microperfusion, to upregulate ECM related genes in the skin, to increase endothelial cell migration and growth of blood vessels, and thus to improve skin health are presented herein.

Abstract: The present invention provides an optimized and/or enriched hydrolyzable tannoid blend derived from Terminalia chebula. In an embodiment the present invention further relates to the use of an extract of Terminalia chebula for treatment of osteoarthritis. In another embodiment, a T. chebula extract composition contains about 8-25% by weight chebulagic acid, about 15-30% by weight chebulinic acid and about 10-40% by weight other low molecular weight hydrolyzable tannoids. This embodiment provides a T. chebula enriched tannoid blend composition (TC/enriched tannoid blend). In another embodiment, a method of treating osteoarthritis in an individual is provided, comprising administering to the individual in need thereof a therapeutically effective amount of the T. chebula extract composition.

Abstract: A group of indolealkylamino-withasteroid conjugates, isolated and purified from Withania somnifera, are described. A synthetic method of making an indolealkylamino-withasteroid compound is provided. In vitro acetyl cholinesterase inhibitory activity and methods for treatment of dementia and dementia-related disorders, such as Alzheimer's disease, and anxiety and depressive disorders in mammals are demonstrated with these novel compositions.

Abstract: A synergistic combination of Urolithin A (3,8-dihydroxy-dibenzo-alpha-pyrone) and Urolithin B (3-hydroxy-dibenzo-alpha-pyrone) is provided in a particular effective ratio, optionally in a nutraceutical or pharmaceutical composition. The composition is for use in treating cognitive deficits, including increasing cognitive function or cognitive capacity (nootropic activity). The composition is for use in treating or preventing a dementia-related disorder in a human subject, such as anxiety or Alzheimer's disease, and for inhibition of acetylcholinesterase (AChE).

Abstract: Chromium-three cation containing compositions in synergistic combination with Phyllanthus emblica extract and Shilajit are useful for improvement of endothelial function and cardiovascular health, including treatment of type 2 diabetes and metabolic syndrome.

Abstract: A method of using dibenzo-alpha-pyrones (DBPs) is provided wherein a subject is administered one or more of the aforementioned resulting in decreased body weight gain. In an embodiment, a 3-OH-DBP, 3,8-(OH)2-DBP, or a combination thereof is administered to an individual to control body weight gain.

Abstract: Compositions containing extracts of Terminalia chebula and Terminalia bellerica, or combinations thereof and methods for treatment of uricemia, hyperuricemia, and gout in a human subject are provided.