Patents Assigned to Nattermann & Cie GmbH
  • Publication number: 20140072661
    Abstract: The present invention relates to an alcohol-free liquid pharmaceutical composition comprising thyme liquid extract and primula root liquid extract and a non-alcoholic solvent and optionally non-alcoholic excipients, preferably chosen from sucrose, invert sugar, water and mixtures thereof. The alcohol-free liquid pharmaceutical composition of present invention intends preferably to have a herbal fingerprint that is comparable to the Bronchicum Elixir alcohol-containing composition. The invention also discloses methods for preparing said alcohol-free liquid pharmaceutical composition. The invention relates also to thyme and primula root liquid extract that may be obtained according to one of the methods described and to the use of the said thyme and primula root liquid extract for the preparation of a pharmaceutical composition.
    Type: Application
    Filed: May 16, 2012
    Publication date: March 13, 2014
    Applicant: A NATTERMANN & CIE GMBH
    Inventors: Verena Hoffmann, Werner Holzstein, Joern Weissenfeld
  • Patent number: 5948800
    Abstract: The present invention is directed to a drug for preventing or remedying Alzheimer's disease. The drug contains as the active ingredient 2-phenyl-1,2-benzisoselenazol-3(2H)-one (referred as compound (A)), whose effect is based on the action of reducing neuron toxicity induced by .beta.-amyloid protein.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: September 7, 1999
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Ikuro Maruyama, Kazuhiro Abeyama, Hiroyuki Masayasu
  • Patent number: 5741517
    Abstract: An aqueous liposome system which contains at least one phospholipid and selectively a non-toxic organic solvent. In addition to the at least one phospholipid the liposome system contains at least one phospholipidic charge carrier.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: April 21, 1998
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Jorg Hager, Manfred Durr, Ernst Lunebach
  • Patent number: 5556637
    Abstract: An aqueous liposome system which contains at least one phospholipid and selectively a non-toxic organic solvent. In addition to the at least one phospholipid the liposome system contains at least one phospholipidic charge carrier.
    Type: Grant
    Filed: January 11, 1995
    Date of Patent: September 17, 1996
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: J org Hager, Manfred D urr, Ernst L unebach
  • Patent number: 5321145
    Abstract: A process of producing phosphatidylcholine derivatives by the reaction of glycerophosphatidylcholine with at least one fatty acid anhydride in the presence of a pyridine catalyst is described. The reaction is carried out in a melt of the glycerophosphatidylcholine, the at least one fatty acid anhydride and the catalyst.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: June 14, 1994
    Assignee: A. Nattermann & Cie. GmbH
    Inventor: Thomas Schafer
  • Patent number: 5288734
    Abstract: The present invention is related to new parenteral preparations of 2-phenyl-1.2-benzisoselenazol-3(2H)-one (Ebselen) comprising additionally one or several phospholipids and, possibly, one or several auxiliary agents. The invention is further related to a process for producing such solutions and their use in the preparation of drug preparations ob Ebselen.
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: February 22, 1994
    Assignee: A. Nattermann & CIE GmbH
    Inventors: Joerg Hager, Andrea M. Huether, Joachim Roeding
  • Patent number: 5183680
    Abstract: A baking agent and a process for producing a baking agent for leavened doughs includes a phospholipid fraction whereby the portion of phosphatidyl choline to phophtidyl ethanolamine is lower than 1.
    Type: Grant
    Filed: August 8, 1991
    Date of Patent: February 2, 1993
    Assignee: A. Nattermann & Cie. GmbH Corporation of the Federal Republic of Germany
    Inventor: Heinz D. Jodlbauer
  • Patent number: 5176935
    Abstract: A baking agent for breakfast-roll doughs includes a phospholopid fraction in which the portion of phosphatidyl choline to phosphatidyl ehtanolamine is greater than 1. A method for producing such a baking agent is also included.
    Type: Grant
    Filed: June 16, 1992
    Date of Patent: January 5, 1993
    Assignees: Vereinigte Kunstmuhlen AG, A. Nattermann & Cie. GmbH
    Inventor: Heinz D. Jodlbauer
  • Patent number: 5141955
    Abstract: Anti-inflammatory benzylselanobenzamides made from anilines and benzylamines have the formula I ##STR1## are disclosed wherein R is hydrogen, methyl or ethyl;R.sup.1 and R.sup.2 are the same or different and, taken separately, are hydrogen, fluorine, chlorine, bromine, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, cyano, amino, dimethylamino or nitro; andR.sup.3 and R.sup.4 are the same or different and, taken separately, are hydrogen, fluorine, chlorine, bromine, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, cyano, or nitro and, taken together, represent methylenedioxy; andn is 0.1 or 2.
    Type: Grant
    Filed: November 8, 1990
    Date of Patent: August 25, 1992
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Michel Evers, Hartmut Fischer, Jurgen Biedermann, Rolf Terlinden, Sigurd Leyck
  • Patent number: 5129950
    Abstract: The invention is related to the use of certain water-soluble compounds known as such and having the FormulaR.sup.1 --CO--NH--R.sup.2for the modulation of membrane dependent metabolism processes within living cells, in particular with relation to transport phenomena and cell procedures which are induced or influenced by active agents supplied from outside the cell, products containing these substances for the above described uses and processes using these products.
    Type: Grant
    Filed: December 6, 1990
    Date of Patent: July 14, 1992
    Assignee: A Nattermann & Cie GmbH
    Inventors: Miklos Ghyczy, Jorg Hager
  • Patent number: 5126357
    Abstract: A compound or a pharmaceutically acceptable salt thereof, having anti-inflammatory activity, is disclosed according to the Formula (I) ##STR1## wherein R is hydrogen, methyl or ethyl,R.sub.1 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group or is phenyl, chlorophenyl or fluorophenyl,R.sub.2 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group,R.sub.3 and R.sub.4 are identical or different and, taken separately, are hydrogen, fluorine, chlorine, bromine, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, cyano or nitro or, taken together, are methylenedioxy, and n is 0 or 1.
    Type: Grant
    Filed: November 8, 1990
    Date of Patent: June 30, 1992
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Michel Evers, Michael Parnham, Axel Romer, Hartmut Fischer, Norbert Dereu
  • Patent number: 5114928
    Abstract: The invention relates to a solid phospholipid composition with a high phosphatidylcholine content which, in addition to the corresponding phospholipids, contains Palatinit and if appropriate one or more other auxiliaries, and a process for its preparation and its use as an oral presentation form.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: May 19, 1992
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Benedikt Gajdos, Heinz J. Mentzen
  • Patent number: 5114954
    Abstract: Benzylselenobenzamides of formula I ##STR1## with inflammation-inhibiting characteristics and used in pharmaceutical preparations.
    Type: Grant
    Filed: November 8, 1990
    Date of Patent: May 19, 1992
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Jurgen Biedermann, Michel Evers, Rolf Terlinden, Sigurd Leyck, Erich Graf
  • Patent number: 5093354
    Abstract: A method of treating obstruction dermatoses, ulcus cruris, ulcus cruris venosum and decubital ulcers, is disclosed, which comprises topically treating an affected patient with a therapeutically effective amount of a pharmaceutical composition containing as active ingredient a therapeutically effective amount of 2',4',6'-trimethoxy-4-(1-pyrrolidinyl) butyrophenone or p-desmethyl-2', 4',6'-trimethoxy-4-(1-pyrrolidinyl) butyrophenone, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 8, 1991
    Date of Patent: March 3, 1992
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Wolfgang Viehmann, Thomas Hogn
  • Patent number: 5021242
    Abstract: The invention is related to solid drug preparations of 2-phenyl-1,2-benzisoselenazol-3(2H)-one (EBSELEN) with high bioavailability comprising EBSELEN in the form of micronized crystals, and a method of manufacturing the same.
    Type: Grant
    Filed: June 20, 1988
    Date of Patent: June 4, 1991
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Axel Romer, Jurgen Seidel
  • Patent number: 5008394
    Abstract: The invention is related to a process for preparing highly pure Ebselen (2-phenyl-1.
    Type: Grant
    Filed: August 9, 1989
    Date of Patent: April 16, 1991
    Assignee: A. Nattermann & Cie, GmbH
    Inventors: Bernd-Rainer Gunther, Rainer Losch, Klaus Steiner
  • Patent number: 4983327
    Abstract: A process for isolating a phosphatidylcholine from vegetable lipid mixtures wherein the lipid mixture is dissolved in a solvent mixture of a low boiling petroleum ether fraction (40.degree.-80.degree. C.), a lower C.sub.1 -C.sub.4 -alkanol and water, the solution is introduced into a column filled with silica gel at a temperature in the range of 20.degree. to 50.degree. C., the elution is carried out at that temperature with the same solvent mixture and the main run is collected and a pure phosphatidylcholine free of other phospholipids present in the starting vegetable lipid mixture is isolated therefrom in a usual manner.
    Type: Grant
    Filed: June 30, 1988
    Date of Patent: January 8, 1991
    Assignee: A. Nattermann & CIE GmbH
    Inventors: Bernd-Rainer Gunther, Rainer Losch
  • Patent number: 4910313
    Abstract: The present invention is related to new diselenobis benzoic acid amides of primary heterocyclic amines of the general formula I ##STR1## process for producing the same and process for treating certain diseases in human beings by administration of the same to the humans suffering from such diseases.
    Type: Grant
    Filed: August 6, 1987
    Date of Patent: March 20, 1990
    Assignee: Nattermann & CIE GmbH
    Inventors: Andre Welter, Axel Roemer, Sigurd Leyck, Michael J. Parnham
  • Patent number: 4906813
    Abstract: Process and device for applying markings (9) and/or providing break notches on moulded items or tablets (4) by means of laser beams. The installation (16) which produces the laser beam (3) is arranged on a tablet-producing press, to which it is functionally connected by synchronization systems (18). A deflection system (17) is arranged on the die support (5) of the press in order to deflect the laser beam (3) onto the surface of the moulded item or tablet (4). The laser (16) is provided with an optical system (15) having interchangeable masks provided with openings through which the laser beam passes (3).
    Type: Grant
    Filed: July 28, 1988
    Date of Patent: March 6, 1990
    Assignee: A. Nattermann & CIE GmbH
    Inventor: Benedikt Gajdos
  • Patent number: 4874553
    Abstract: Liquid phospholipid-containing products in an aqueous medium which contains 5-80% by weight of phospholipids and 3-10% by weight of one or more compounds of the general formulaRO--A--NR.sub.1 R.sub.2 R.sub.3their preparation and their use, for example as additives for improving plant treatment agents.
    Type: Grant
    Filed: March 11, 1987
    Date of Patent: October 17, 1989
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Hager, Jorg, Miklos Ghyczy, Vincent Feyen, Paul Imberge, Ulrich Brandenburg, Peter Wilperath