Abstract: The present disclosure provides compositions and methods for preventing or treating non-alcoholic steatohepatitis. The composition comprises phytosterol particles, and at least a portion of the phytosterol particles have a size of less about 1 micron. The method comprises administering orally a daily dose of at least about 2 g of phytosterol comprising free phytosterol particles having a size less than about 1 micron. Both animal model studies and human trial studies confirmed the effectiveness of the compositions and methods.
Type:
Grant
Filed:
March 9, 2021
Date of Patent:
March 29, 2022
Assignee:
Naturalis S.A.
Inventors:
Mariá Cecilia Brañes Oshima, Thomas Haack, Thomas Härting Glade
Abstract: Carrier fluid compositions and their use in processes for reducing the concentration of persistent organic pollutants, such as polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzo-p-furans (PCDDF), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and pesticides, such as chlorinated hydrocarbons, chlorinated toxaphenes and camphenes, in fish oil are disclosed. The process includes vacuum distillation of the fish oil in the presence of the carrier fluid compositions to provide a fish oil residue having a reduced concentration of persistent organic pollutants.
Type:
Grant
Filed:
January 4, 2012
Date of Patent:
September 4, 2012
Assignee:
Naturalis, S.A.
Inventors:
Thomas Francis Harting Glade, Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas