Abstract: A detoxification system can include an effective amount of a probiotic component and a fiber component in combination with a circulation enhancing component, a high-protein meal replacement component, or both. The detoxification system increases urinary heavy metal excretion, decreases a fecal zonulin level, decreases a fecal calprotectin level, decreases a serum lipopolysaccharide binding protein (LBP) level, increases at least one of a salivary nitrite level and a serum arginine level, or a combination thereof in a subject as compared to a baseline level prior to administration of the detoxification system in an effective dosing regimen.

Abstract: Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide; an effective amount of a NOS independent source of nitric oxide; and an effective amount of a myeloperoxidase inhibitor; wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting meyloperoxidase activity.

Abstract: Compositions comprising apple, grape, green tea, and olive extracts are presented herein. This synergistic formulations apple, grape, green tea, and olive extract are in amounts that provide a greater antioxidant activity or protein kinase modulating activity than provided by an equivalent amount of any one extract or a sum of the extracts. Further presented are methods of regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent. Also presented are methods of making an activity enhancing composition for regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent.

Abstract: Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide; an effective amount of a NOS independent source of nitric oxide; and an effective amount of a myeloperoxidase inhibitor; wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting myeloperoxidase activity.

Abstract: A weight loss system is presented herein. In one embodiment, the weight loss system that accelerates weight loss in a subject eating a caloric restricted diet with a minimum daily protein intake of about 3 oz. and engaging in daily physical activity equivalent to about 5,000 steps per day is presented. The weight loss system can comprise an effective amount of: an antimicrobial component that includes berberine, cinnamon and curcumin; fish oil; a probiotic component that includes Lactobacillus spp., Bifidobacterium spp., and Streptococcus spp.; an antioxidant, phytochemical component that includes apple extract, grape extract, green tea extract, and olive extract; and a vitamin component that includes vitamins A, B, C, D, and E. The weight loss system can stimulate a weight loss of at least 3% more than if not administered to the subject. Further presented herein is a method of facilitating weight loss in a subject and a method of improving the health of a subject participating in a weight loss program.

Abstract: A detoxification system can include an effective amount of a probiotic component and a fiber component in combination with a circulation enhancing component, a high-protein meal replacement component, or both. The detoxification system increases urinary heavy metal excretion, decreases a fecal zonulin level, decreases a fecal calprotectin level, decreases a serum lipopolysaccharide binding protein (LBP) level, increases at least one of a salivary nitrite level and a serum arginine level, or a combination thereof in a subject as compared to a baseline level prior to administration of the detoxification system in an effective dosing regimen.

Abstract: Compositions comprising apple, grape, green tea, and olive extracts are presented herein. This synergistic formulations apple, grape, green tea, and olive extract are in amounts that provide a greater antioxidant activity or protein kinase modulating activity than provided by an equivalent amount of any one extract or a sum of the extracts. Further presented are methods of regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent. Also presented are methods of making an activity enhancing composition for regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent.

Abstract: Compositions comprising apple, grape, green tea, and olive extracts are presented herein. This synergistic formulations apple, grape, green tea, and olive extract are in amounts that provide a greater antioxidant activity or protein kinase modulating activity than provided by an equivalent amount of any one extract or a sum of the extracts. Further presented are methods of regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent. Also presented are methods of making an activity enhancing composition for regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent.

Abstract: A weight loss system is presented herein. In one embodiment, the weight loss system that accelerates weight loss in a subject eating a caloric restricted diet with a minimum daily protein intake of about 3 oz. and engaging in daily physical activity equivalent to about 5,000 steps per day is presented. The weight loss system can comprise an effective amount of: an antimicrobial component that includes berberine, cinnamon and curcumin; fish oil; a probiotic component that includes Lactobacillus spp., Bifidobacterium spp., and Streptococcus spp.; an antioxidant, phytochemical component that includes apple extract, grape extract, green tea extract, and olive extract; and a vitamin component that includes vitamins A, B, C, D, and E. The weight loss system can stimulate a weight loss of at least 3% more than if not administered to the subject. Further presented herein is a method of facilitating weight loss in a subject and a method of improving the health of a subject participating in a weight loss program.

Abstract: Phosphodiesterase-4 (PDE4) inhibiting compositions comprising a Sceletium and an activity enhancer are disclosed and described. Methods and systems for inhibiting PDE4, as well as, dosage forms comprising a Sceletium extract and an activity enhancer are also disclosed. Additionally disclosed are methods for enhancing the potency or PDE4 inhibitory activity of a Sceletium extract by addition of an activity enhancer.

Abstract: Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide; an effective amount of a NOS independent source of nitric oxide; and an effective amount of a myeloperoxidase inhibitor; wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting meyloperoxidase activity.

Abstract: Phosphodiesterase (PDE) such as phosphodiesterase type V (PDE5) inhibiting compositions comprising a Sceletium extract are disclosed and described. Methods and systems for inhibiting PDE, as well as, dosage forms comprising a Sceletium extract are also disclosed. Additionally disclosed are methods for enhancing the potency or PDE inhibitory activity of a Sceletium extract by addition of an activity enhancer.

Abstract: Phosphodiesterase-4 (PDE4) inhibiting compositions comprising a Sceletium and an activity enhancer are disclosed and described. Methods and systems for inhibiting PDE4, as well as, dosage forms comprising a Sceletium extract and an activity enhancer are also disclosed. Additionally disclosed are methods for enhancing the potency or PDE4 inhibitory activity of a Sceletium extract by addition of an activity enhancer.

Abstract: Compositions comprising apple, grape, green tea, and olive extracts are presented herein. This synergistic formulations apple, grape, green tea, and olive extract are in amounts that provide a greater antioxidant activity or protein kinase modulating activity than provided by an equivalent amount of any one extract or a sum of the extracts. Further presented are methods of regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent. Also presented are methods of making an activity enhancing composition for regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent.

Abstract: A crude extract composition derived from the plant family Annonaceae and the method for producing the crude extract composition. Medicinal benefits of the extract include tumor regression and the reduction of tumor antigen levels.

Abstract: The present invention is an dietary supplement which inhibits the assimilation of dietary fat during digestion, and method of making and using the same. The composition includes surfactant and non-digestible dietary fiber. In a preferred embodiment of the invention, the composition further comprises an emulsifying agent. The composition may be taken before, during or after eating.

Abstract: The present invention is an orally-administrable composition for preventing and treating Helicobacter pylori-associated stomach gastritis and ulcers, and for preventing Helicobacter pylori-associated stomach cancer. The invention is a herb or herb extract containing an anti-H. pylori activity. The invention further includes methods for making and methods for using the invention.

Abstract: The present invention is an orally- or topically-administrable composition for preventing and treating hair loss. The invention is a plant or plant extract containing isoflavones having a weak estrogen activity. The invention further includes methods for using the invented composition to prevent and treat hair loss.

Abstract: A compact, high flow rate reverse osmosis water filtration system suitable for home use has four primary operating components--a carbon sediment pre-filter assembly, a reverse osmosis filter assembly, a granulated activated carbon post-filter assembly, and a flow controller. These four components are operatively interconnected by lengths of flexible tubing provided with finger operable quick disconnect fittings which permit each element to be rapidly disconnected from and reconnected to the balance of the system without the use of tools of any sort. Each of the three filter assemblies is of a throw-away construction comprising a filter material permanently sealed within a housing structure. Filter changeout is thus easily and quickly achieved by the homeowner simply by disconnecting the particular filter assembly and discarding it, housing and all, and then quickly reconnecting a replacement filter assembly in the system.

Abstract: A portable water purification system includes a generally rectangular boxlike chest containing a particulate matter prefilter, a reverse osmosis filter and an activated carbon postfilter unit disposed in a lower base part of the chest. The prefilter, reverse osmosis filter and postfilter units are connected in series by flexible conduits. The chest includes a removable tray section provided with receptacles for receiving a plurality of connector assemblies, a raw water diverter valve, and flexible conduits interconnecting the filter units with the raw water source, a waste water discharge line and connector assemblies for serially connecting a plurality of pure water storage containers comprising conventional plastic milk jug type containers.