Patents Assigned to NATURE'S TOOLBOX, INC.
  • Methods and compositions for the enzymatic production of pseudouridine triphosphate
    Patent number: 12247236
    Abstract: The present invention includes novel systems, methods, and compositions for the enzymatic/chemical production of pseudouridine (?) and its variants, such as N1-methyl-pseudouridine-5?-triphosphate (m1?TP).
    Type: Grant
    Filed: March 21, 2024
    Date of Patent: March 11, 2025
    Assignee: NATURE'S TOOLBOX, INC.
    Inventors: Alexander Koglin, Michael Humbert, Matthias Strieker, Grant Eliason
  • Cell-free expression system having novel inorganic polyphosphate-based energy regeneration
    Patent number: 12227778
    Abstract: The invention relates to an in vitro cell-free expression system incorporating a novel inorganic polyphosphate-based energy regeneration system. In certain embodiments, the invention includes a cell-free expression system where the cellular energy source, ATP, is regenerated from inorganic polyphosphate using a dual enzyme system. In this embodiment, this dual enzyme system may include thermostable Adenosyl Kinase, and/or Polyphosphate Kinase enzymes.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: February 18, 2025
    Assignee: NATURE'S TOOLBOX, INC.
    Inventors: Alexander Koglin, Michael Humbert
  • Methods and compositions for the enzymatic production of pseudouridine triphosphate
    Patent number: 11959117
    Abstract: The present invention includes novel systems, methods, and compositions for the enzymatic/chemical production of pseudouridine (?) and its variants, such as N1-methyl-pseudouridine-5?-triphosphate (m1?TP).
    Type: Grant
    Filed: June 6, 2023
    Date of Patent: April 16, 2024
    Assignee: NATURE'S TOOLBOX, INC.
    Inventors: Alexander Koglin, Michael Humbert, Matthias Strieker, Grant Eliason