Patents Assigned to Nature Technology Corp
  • Strains of for plasmid DNA production
    Patent number: 8748168
    Abstract: A general method and strains of bacteria are described, by means of which it is possible to dramatically purify plasmid DNA with respect to genomic DNA, and RNA. In one preferred embodiment, lysis and nuclease removal of host nucleic acids is an integral component of the fermentation/harvest process, and as such, achieves increased yield and purity with simplified downstream purification and reduced waste streams, thus reducing production costs.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: June 10, 2014
    Assignee: Nature Technology Corp.
    Inventors: James A. Williams, Clague P. Hodgson
  • PROCESS FOR PLASMID DNA FERMENTATION
    Publication number: 20110281304
    Abstract: Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity in a fermentor. These processes feature fed-batch fermentation strategies, combined with novel growth and induction phase temperature shifts.
    Type: Application
    Filed: May 16, 2011
    Publication date: November 17, 2011
    Applicant: Nature Technology Corp.
    Inventors: Aaron E. CARNES, James A. Williams
  • Process for plasmid DNA fermentation
    Patent number: 7943377
    Abstract: Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity in a fermentor. These processes feature Fed-batch fermentation strategies, combined with novel growth and induction phase temperature shifts.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: May 17, 2011
    Assignee: Nature Technology Corp.
    Inventors: Aaron E. Carnes, James A. Williams
  • COMPOSITIONS AND PROCESSES FOR IMPROVED PLASMID DNA PRODUCTION
    Publication number: 20100167358
    Abstract: Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity. These processes feature RNA based inducers of plasmid copy number.
    Type: Application
    Filed: January 27, 2006
    Publication date: July 1, 2010
    Applicant: NATURE TECHNOLOGY CORP.
    Inventor: James A. Williams
  • Thermostable Fusion Proteins and Thermostable Adjuvant
    Publication number: 20100125129
    Abstract: Fusion proteins including maltodextrin-binding protein (MBP) domains that are thermally stable and soluble are provided. Methods for forming and using the fusion proteins are also provided.
    Type: Application
    Filed: November 19, 2009
    Publication date: May 20, 2010
    Applicant: NATURE TECHNOLOGY CORP.
    Inventor: James A. Williams
  • Vectors And Methods For Genetic Immunization
    Publication number: 20080145376
    Abstract: Improved DNA vaccine plasmids are disclosed. The improved plasmids eliminate all extraneous sequences, and have superior eukaryotic expression, improved yield and stability during bacterial production, facilitate flexible targeting of antigens to various intracellular destinations, and novel RNA-based functionality. These vectors are utilized in novel immunization methods wherein combinations of immunostimulatory DNA vaccine plasmids that target antigens to various intracellular destinations are used to elicit improved immune response.
    Type: Application
    Filed: January 20, 2006
    Publication date: June 19, 2008
    Applicant: NATURE TECHNOLOGY CORP.
    Inventor: James A. Williams
  • Process for Plasmid Dna Fermentation
    Publication number: 20070254342
    Abstract: Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity in a fermentor. These processes feature Fed-batch fermentation strategies, combined with novel growth and induction phase temperature shifts.
    Type: Application
    Filed: August 16, 2005
    Publication date: November 1, 2007
    Applicant: NATURE TECHNOLOGY CORP.
    Inventors: Aaron Carnes, James Williams
  • Self-assembling genes, vectors and uses thereof
    Patent number: 6410220
    Abstract: The invention relates to a method for directing the self-assembly of a gene or gene assembly having three and preferably six or more fragments in a directionally and spatially ordered fashion to produce a gene, gene vector or large nucleic acid molecule. The method can be used to create libraries, such as combinatorial libraries. In another embodiment of the invention a vector is described for the incorporation and screeming of endogenous mouse promoter elements for the identification of cell-specific promoters.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: June 25, 2002
    Assignee: Nature Technology Corp
    Inventors: Clague P. Hodgson, Mary Ann Zink, Guoping Xu