Patents Assigned to NATUREX
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Patent number: 9487552Abstract: The invention relates to a method for preparing a refined extract of Centella asiatica comprising a mixture of madecassoside and terminoloside. The method comprises: passage over adsorbent resin; elution with an eluent comprising at least 30 wt. % of an alcoholic solvent; and a recrystallization step using a mixture of solvents, comprising water and an alcoholic solvent.Type: GrantFiled: September 2, 2011Date of Patent: November 8, 2016Assignee: NATUREX, S.A.Inventor: Charles Duval
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Publication number: 20160287655Abstract: A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 4-caffeoylquinic acid (4-CQA) to total chlorogenic acids (tCGA) (5-CQA/tCGA) of from about 0.1 to about 0.2. More preferably, the green coffee extract comprises from about 6% to about 8% of 4-caffeoylquinic acid and has a total chlorogenic acid concentration that exceeds about 45%. A preferred method of administration consists of administering the green coffee extracts is a dosage of about 200 mg twice a day prior to meals on an empty stomach.Type: ApplicationFiled: June 6, 2016Publication date: October 6, 2016Applicant: NATUREX, S.A.Inventors: Alvin IBARRA, Marc ROLLER, Jacques DIKANSKY
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Publication number: 20160220624Abstract: A composition for improving muscle metabolism in a subject and methods for manufacturing and using same. Embodiments include compositions having an extract of Rhaponticum and an extract of Rhodiola. An extract of Rhaponticum may include amounts of ecdysterones including 20-hydroxyecdysone. An extract of Rhodiola my include salidrosides and rosavins, including rosavin. Suitable ingestion dosages of the composition may be operable to increase protein synthesis and reduce protein proteolysis in a subject.Type: ApplicationFiled: February 3, 2015Publication date: August 4, 2016Applicant: Naturex SAInventors: Antoine Charles Bily, Marjolaine Meyer, Karl Chevalier, Lise Laurençon, Nicolas Feuillere, Marc Roller, Simona Birtic
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Patent number: 9358264Abstract: A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 4-caffeoylquinic acid (4-CQA) to total chlorogenic acids (tCGA) (5-CQA/tCGA) of from about 0.1 to about 0.2. More preferably, the green coffee extract comprises from about 6% to about 8% of 4-caffeoylquinic acid and has a total chlorogenic acid concentration that exceeds about 45%. A preferred method of administration consists of administering the green coffee extracts is a dosage of about 200 mg twice a day prior to meals on an empty stomach.Type: GrantFiled: March 25, 2011Date of Patent: June 7, 2016Assignee: NATUREX, S.A.Inventors: Alvin Ibarra, Marc Roller, Jacques DiKansky
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Publication number: 20160015766Abstract: A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 4-caffeoylquinic acid (4-CQA) to total chlorogenic acids (tCGA) (5-CQA/tCGA) of from about 0.1 to about 0.2. More preferably, the green coffee extract comprises from about 6% to about 8% of 4-caffeoylquinic acid and has a total chlorogenic acid concentration that exceeds about 45%. A preferred method of administration consists of administering the green coffee extracts is a dosage of about 200 mg twice a day prior to meals on an empty stomach.Type: ApplicationFiled: March 25, 2011Publication date: January 21, 2016Applicant: NATUREX, S.A.Inventors: Alvin IBARRA, Marc ROLLER, Jacques DIKANSKY
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Publication number: 20150306119Abstract: Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total ginsenosides enhance cognitive function—including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.Type: ApplicationFiled: February 27, 2015Publication date: October 29, 2015Applicant: NATUREX, S.A.Inventors: Andrew SCHOLEY, Alvin IBARRA, Kan HE, Marc ROLLER, Jacques DIKANSKY
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Patent number: 9011936Abstract: Disclosed are methods of alleviating oxidative stress, regulating blood glucose levels, and controlling pancreatic lipase activity by administering a Rosemary extract. Such methods may be useful to help body weight and body fat, prevent obesity, and treat hyperglycemia, hyperinsulinemia, cardiovascular disease and Type-2 diabetes. Preferred extracts contain 20% or 50% carnosic acid.Type: GrantFiled: October 16, 2009Date of Patent: April 21, 2015Assignee: Naturex, S.A.Inventors: Kan He, Marc Roller, Alvin Ibarra, Naisheng Bai, Jacques DiKansky
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Patent number: 8980342Abstract: A method of enhancing physical performance during exercise by administering an amount of a grape extract effective to treat a subject. A preferred grape extract comprises a concentration of flavanol monomers of greater than about 5% by weight, and more preferably within a range from about 12% by weight to about 50% by weight, and a concentration of flavanol dimers preferably greater than about 2% by weight, and more preferably within a range from about 6% by weight to about 20% by weight. The flavanol monomers preferably include catechin, epicatechin, epicatechin gallate, and gallic acid. The flavanol dimers preferably include procyanidin B1, procyanidin B2, procyanidin B3, procyanidin B4, and procyanidin B2-O-gallate.Type: GrantFiled: August 20, 2008Date of Patent: March 17, 2015Assignee: Naturex, S.A.Inventors: Benoit Lemaire, Sophie Lafay, Alvin Ibarra, Marc Roller, Jacques DiKansky
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Publication number: 20150072042Abstract: A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 4-caffeoylquinic acid (4-CQA) to total chlorogenic acids (tCGA) (5-CQA/tCGA) of from about 0.1 to about 0.2. More preferably, the green coffee extract comprises from about 6% to about 8% of 4-caffeoylquinic acid and has a total chlorogenic acid concentration that exceeds about 45%. A preferred method of administration consists of administering the green coffee extracts is a dosage of about 200 mg twice a day prior to meals on an empty stomach.Type: ApplicationFiled: March 25, 2011Publication date: March 12, 2015Applicant: NATUREX, S.A.Inventors: Alvin IBARRA, Marc ROLLER, Jacques DiKANSKY
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Patent number: 8968800Abstract: Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total genosides enhance cognitive function—including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.Type: GrantFiled: November 3, 2011Date of Patent: March 3, 2015Assignee: Naturex, S.A.Inventors: Andrew Scholey, Alvin Ibarra, Kan He, Marc Roller, Jacques Dikansky
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Patent number: 8946383Abstract: The present invention relates to obtaining bioactive peptides from plant raw materials, specifically cocoa extracts, by means of enzyme treatment. Said biopeptides have angiotensin converting enzyme (ACE) and prolyl endopeptidase enzyme (PEP) inhibitory activity in vitro and/or antioxidant activity in vivo, being able to be used in the food, dietetic and pharmaceutical industry.Type: GrantFiled: August 1, 2008Date of Patent: February 3, 2015Assignee: NaturexInventors: Begoña Muguerza Marquínez, Honorato Monzo Oltra, Natalia Alepuz Rico, Esther Bataller Leiva, Salvador Genoves Martínez, Maria Enrique López, Patricia Guerola Guerola, Daniel Ramon Vidal
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Patent number: 8664185Abstract: A method for preparing a concentrated spinach extract in a liquid or dry form and having a polyphenol titer greater than or equal to 50% is described. The method includes a step of purifying a raw spinach extract in a liquid form using a liquid-liquid extraction technique with a food oil.Type: GrantFiled: May 4, 2010Date of Patent: March 4, 2014Assignee: NaturexInventor: Charles Duval
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Patent number: 8293292Abstract: A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S,3E,4S)2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-?-D-glucopyranosyl-?-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-?-D-glucopyranosyl-?-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.Type: GrantFiled: November 10, 2011Date of Patent: October 23, 2012Assignee: Naturex, S.A.Inventors: Kan He, Marc Roller, Antoine Bily, Naisheng Bai, Jacques DiKansky, Alvin Ibarra
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Patent number: 8142826Abstract: A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-?-D-glucopyranosyl-?-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-?-D-glucopyranosyl-?-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.Type: GrantFiled: August 4, 2008Date of Patent: March 27, 2012Assignee: Naturex, Inc.Inventors: Kan He, Marc Roller, Antoine Bily, Naisheng Bai, Jacques Dikansky, Alvin Ibarra
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Publication number: 20070116786Abstract: The present invention relates to compositions containing particular components that can be obtained from a plant which can have pharmaceutical applications. More particularly, the plant genus is Lepidium and the composition may contain in the range of between about 0.3% and 0.7% of benzyl isothiocyanate, b) between about 0.06% and about 0.02% of Lepidium sterol component, c) between about 1% and about 2% of a Lepidium fatty acid component, and d) about 0.006% to 0.6% or more total macamide/macaenes component as standardized with excipients.Type: ApplicationFiled: July 26, 2006Publication date: May 24, 2007Applicant: NATUREXInventors: Qun Zheng, Bo Zheng, Kan He
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Patent number: RE43005Abstract: The invention relates to compositions that can be isolated from Lepidium plant material and to methods for their isolation. The compositions are useful for treating and preventing cancer and sexual dysfunction.Type: GrantFiled: November 21, 2007Date of Patent: December 6, 2011Assignee: Naturex Inc.Inventors: Bo Lin Zheng, Kan He, Yu Shao, Qun Yi Zheng