Patents Assigned to Naval Medical University
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Publication number: 20230279150Abstract: The present disclosure relates to the technical field of biomedicine, and provides an anti-tetrodotoxin humanized antibody and use thereof. The humanized antibody has a heavy-chain variable region and a light-chain variable region with amino acid sequences shown in SEQ ID NO: 1 to SEQ ID NO: 2, respectively. Affinity analysis shows that the antibody of the present disclosure has prominent affinity. It is proved by experiments that, after mice in an antibody protection group pre-injected with the antibody of the present disclosure are injected with tetrodotoxin, most of the mice show no toxic symptoms, and during continuous observation for one month, no toxic lethality occurs, indicating that the antibody of the present disclosure shows excellent anti-tetrodotoxin effects, excellent preventive or therapeutic effects on puffer fish-related biological injuries, and promising clinical application prospects.Type: ApplicationFiled: December 20, 2022Publication date: September 7, 2023Applicant: Naval Medical UniversityInventors: Shi HU, Changhai LEI, Wenyan FU
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Publication number: 20230279149Abstract: The present disclosure relates to the technical field of biomedicine, and provides an anti-tetrodotoxin humanized antibody Y126C and use thereof. The humanized antibody has a heavy-chain variable region and a light-chain variable region with amino acid sequences shown in SEQ ID NO: 1 to SEQ ID NO: 2, respectively. Affinity analysis shows that the antibody of the present disclosure has prominent affinity. It is proved by experiments that, after mice in an antibody protection group pre-injected with the antibody of the present disclosure are injected with tetrodotoxin, most of mice do not show toxic symptoms, and during continuous observation for one month, no toxic lethality occurs, indicating that the antibody of the present disclosure shows excellent anti-tetrodotoxin effects, excellent preventive or therapeutic effects on puffer fish-related biological injuries, and promising clinical application prospects.Type: ApplicationFiled: December 20, 2022Publication date: September 7, 2023Applicant: Naval Medical UniversityInventors: Changhai LEI, Shi HU, Wenyan FU
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Publication number: 20230279148Abstract: The present disclosure relates to the technical field of biomedicine, and provides an anti-tetrodotoxin humanized antibody and use thereof. The humanized antibody has a heavy-chain variable region and a light-chain variable region with amino acid sequences shown in SEQ ID NO: 1 to SEQ ID NO: 2, respectively. Affinity analysis shows that the antibody of the present disclosure has prominent affinity. It is proved by experiments that, after mice in an antibody protection group pre-injected with the antibody of the present disclosure are injected with tetrodotoxin, no mice shows toxic symptoms, and during continuous observation for one month, no toxic lethality occurs, indicating that the antibody of the present disclosure shows excellent anti-tetrodotoxin effects, excellent preventive or therapeutic effects on puffer fish-related biological injuries, and promising clinical application prospects.Type: ApplicationFiled: December 20, 2022Publication date: September 7, 2023Applicant: Naval Medical UniversityInventors: Shi HU, Changhai LEI, Wenyan FU
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Publication number: 20230219220Abstract: The present application relates to the field of error detection technology. An error detection method and a robot system are provided. The error detection method includes: obtaining a target pose of an end of an operating arm; acquiring a positioning image; recognizing, in the positioning image, a plurality of pose identifications located on the end of the operating arm; recognizing, based on the plurality of pose identifications, an angle identification located on the end of the operating arm, the angle identification having a position association relationship with a first pose identification of the plurality of pose identifications; determining, based on the angle identification and the plurality of pose identifications, an actual pose of the end of the operating arm; and generating, in response to the target pose and the actual pose meeting an error detection condition, a control signal related to a fault.Type: ApplicationFiled: December 30, 2022Publication date: July 13, 2023Applicants: The First Affiliated Hospital of Naval Medical University, Beijing Surgerii Technology Co., Ltd.Inventors: Linhui Wang, Bo Yang, Chao Zhang, Zongqin Zhang, Tie Zhou, Hong Xu, Chengwu Xiao, Xiaofeng Wu, Kai Xu
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Publication number: 20230219221Abstract: The present application relates to the field of error detection technology. An error detection method is provided. The error detection method includes: obtaining a target pose of an end of an operating arm; acquiring a positioning image; recognizing, in the positioning image, a plurality of pose identifications located on the end of the operating arm, the plurality of pose identifications including different pose identification patterns; determining an actual pose of the end of the operating arm based on the plurality of pose identifications; and generating a control signal related to a fault in response to the target pose and the actual pose meeting an error detection condition.Type: ApplicationFiled: December 30, 2022Publication date: July 13, 2023Applicants: The First Affiliated Hospital of Naval Medical University, Beijing Surgerii Technology Co., Ltd.Inventors: Linhui Wang, Bo Yang, Chao Zhang, Zongqin Zhang, Tie Zhou, Hong Xu, Chengwu Xiao, Xiaofeng Wu, Kai Xu
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Publication number: 20220204648Abstract: The present disclosure relates to the technical field of biomedicine, and provides an anti-physaliatoxin nanobody, and a preparation method and use thereof. The nanobody is a VHH antibody with an amino acid sequence shown in SEQ ID NO. 1. Affinity analysis shows that the nanobody of the present disclosure has prominent affinity. It is proved by small animal experiments that, after mice in an antibody protection group pre-injected with the nanobody of the present disclosure are injected with physaliatoxin, no mice shows toxic symptoms, and during continuous observation for one month, no toxic lethality occurs, indicating that the nanobody of the present disclosure shows excellent anti-physaliatoxin effects, excellent preventive or therapeutic effects on jellyfish stings, and promising clinical application prospects.Type: ApplicationFiled: January 19, 2022Publication date: June 30, 2022Applicant: Naval Medical UniversityInventors: Changhai LEI, Shi HU, Wenyan FU