Abstract: The invention relates to the identification of new therapeutic methods for the FGF21 polypeptide or protein, or mutants, variants, and fusions thereof, for instance, in treating metabolic diseases associated defects in insulin signaling (e.g. insulin receptor mutation disorders (INSR disorders) and/or autoimmune insulin receptor disorders (Type B insulin Resistance)), defects in insulin production such as type 1 diabetes mellitus, mixed dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and other metabolic disorders, and various lipodystrophies such as HIV-HAART induced partial-lipodystrophy, and in reducing the mortality and morbidity of critically ill patients.
Type:
Application
Filed:
March 19, 2024
Publication date:
September 5, 2024
Applicant:
Navartis AG
Inventors:
John Louis DIENER, Jiaping GAO, Rick Jerome SCHIEBINGER
Abstract: The invention relates to crystalline forms of 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid and to its amorphous form, to processes for the preparation thereof, to compositions containing the same and their uses for the manufacture of a medicament for the treatment of the human body.
Abstract: The present invention is directed to a process for the production of a porous polymer comprising the steps of: i) forming a mixture comprising a polymerizable component and an organic solvent wherein the polymerizable component comprises at least one macromonomer having at least one perfluoropolyether unit; ii) polymerizing said mixture wherein immediately after the polymerization of said mixture at least a substantial proportion of said organic solvent is in the form of a discrete phase and wherein said discrete organic solvent phase forms an interpenetrating network throughout the mixture or is dispersed throughout the mixture; and iii) removing the discrete organic solvent phase.
Type:
Grant
Filed:
May 10, 1999
Date of Patent:
January 18, 2000
Assignees:
Navartis AG, Commonwealth Scientific & Industrial Research Organisation
Inventors:
Hassan Chaouk, Gordon Francis Meijs, Bronwyn Glenice Laycock