Abstract: Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.

Abstract: Methods are provided for treatment and storage of blood and blood products using at least endogenous alloxazines and acetate. Methods include adding a blood component additive solution comprising at least an endogenous alloxazine and acetate to a fluid comprising at least one collected blood component.

Abstract: This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.

Abstract: This invention provides methods, devices and device components for treating biological samples with electromagnetic radiation. The methods, devices and device components of the present invention are capable of providing well characterized, uniform and reproducible net radiant energies and/or radiant powers to biological samples undergoing processing. In addition, the present methods, devices and device components are capable of delivering electromagnetic radiation to biological samples having a distribution of wavelengths selected to provide enhanced pathogen reduction, while minimizing photoinduced damage to components comprising therapeutic and/or reinfusion agents.