Patents Assigned to Navigen, Inc.
  • ARF6 inhibitors and related methods
    Patent number: 11414442
    Abstract: Methods of treating vascular leak, vascular inflammation, angiogenesis, ocular disorders, and/or inflammatory disorders in a patient are provided. The methods can include administering an ADP-ribosylation factor 6 (ARF6) inhibitor to the patient. The present disclosure also relates to new chemical entities and pharmaceutical compositions including ARF6 inhibitors. The ARF6 inhibitor may be a prodrug of an ARF6 inhibitor.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: August 16, 2022
    Assignee: Navigen, Inc.
    Inventors: Ashok Bajji, Kirill Ostanin, Alan Mueller, Damon Papac
  • Arf6 inhibitors and methods of synthesis and use thereof
    Patent number: 10849901
    Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: December 1, 2020
    Assignees: Navigen, Inc., The University of Utah Research Foundation
    Inventors: Kirill Ostanin, Mark Shenderovich, Ashok Bajji, Christopher L. Cioffi, Neil Moss, Hariprasad Vankayalapati, Dean Li
  • Compositions and methods related to inhibition of respiratory syncytial virus entry
    Patent number: 10765754
    Abstract: Disclosed herein are compositions and methods for inhibiting respiratory syncytial virus (RSV) entry into a host cell. Also provided herein are methods of identifying a peptide that interacts with the N-trimer of RSV F protein.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: September 8, 2020
    Assignees: Navigen, Inc., University of Utah Research Foundation
    Inventors: Brett D. Welch, Michael S. Kay, Debra Muir Eckert, Rena McKinnon, Michael Thomas Jacobsen
  • D-peptide inhibitors of HIV entry and methods of use
    Patent number: 10487121
    Abstract: Disclosed are D-peptide compositions and methods for inhibiting HIV entry into host cells.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: November 26, 2019
    Assignees: Navigen, Inc., University of Utah Research Foundation
    Inventors: Brett D. Welch, James Nicholas Francis, Michael S. Kay
  • Ebolavirus pre-hairpin intermediate mimics and methods of use
    Patent number: 10189878
    Abstract: Ebolavirus is a highly lethal filovirus that causes hemorrhagic fever in humans and non-human primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent unmet global health need. The design, biophysical characterization, and validation of peptide mimics of the ebolavirus N-trimer (“N-trimer mimics”) are described herein.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: January 29, 2019
    Assignees: University of Utah Research Foundation, Navigen, Inc., The United States of America—Air Force
    Inventors: Tracy R. Clinton, Michael Thomas Jacobsen, Matthew T. Weinstock, Brett D. Welch, Debra Muir Eckert, Michael S. Kay
  • ARF6 INHIBITORS AND METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20170189405
    Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.
    Type: Application
    Filed: May 27, 2015
    Publication date: July 6, 2017
    Applicants: Navigen, Inc., The University of Utah Research Foundation
    Inventors: Kirill Ostanin, Mark Shenderovich, Ashok Bajji, Christopher L. Cioffi, Neil Moss, Hariprasad Vankayalapati, Dean Li