Patents Assigned to Navigenics, Inc.
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Patent number: 11414442Abstract: Methods of treating vascular leak, vascular inflammation, angiogenesis, ocular disorders, and/or inflammatory disorders in a patient are provided. The methods can include administering an ADP-ribosylation factor 6 (ARF6) inhibitor to the patient. The present disclosure also relates to new chemical entities and pharmaceutical compositions including ARF6 inhibitors. The ARF6 inhibitor may be a prodrug of an ARF6 inhibitor.Type: GrantFiled: February 21, 2020Date of Patent: August 16, 2022Assignee: Navigen, Inc.Inventors: Ashok Bajji, Kirill Ostanin, Alan Mueller, Damon Papac
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Patent number: 10849901Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.Type: GrantFiled: May 27, 2015Date of Patent: December 1, 2020Assignees: Navigen, Inc., The University of Utah Research FoundationInventors: Kirill Ostanin, Mark Shenderovich, Ashok Bajji, Christopher L. Cioffi, Neil Moss, Hariprasad Vankayalapati, Dean Li
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Patent number: 10765754Abstract: Disclosed herein are compositions and methods for inhibiting respiratory syncytial virus (RSV) entry into a host cell. Also provided herein are methods of identifying a peptide that interacts with the N-trimer of RSV F protein.Type: GrantFiled: August 26, 2016Date of Patent: September 8, 2020Assignees: Navigen, Inc., University of Utah Research FoundationInventors: Brett D. Welch, Michael S. Kay, Debra Muir Eckert, Rena McKinnon, Michael Thomas Jacobsen
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Patent number: 10487121Abstract: Disclosed are D-peptide compositions and methods for inhibiting HIV entry into host cells.Type: GrantFiled: January 6, 2017Date of Patent: November 26, 2019Assignees: Navigen, Inc., University of Utah Research FoundationInventors: Brett D. Welch, James Nicholas Francis, Michael S. Kay
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Patent number: 10189878Abstract: Ebolavirus is a highly lethal filovirus that causes hemorrhagic fever in humans and non-human primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent unmet global health need. The design, biophysical characterization, and validation of peptide mimics of the ebolavirus N-trimer (“N-trimer mimics”) are described herein.Type: GrantFiled: September 24, 2015Date of Patent: January 29, 2019Assignees: University of Utah Research Foundation, Navigen, Inc., The United States of America—Air ForceInventors: Tracy R. Clinton, Michael Thomas Jacobsen, Matthew T. Weinstock, Brett D. Welch, Debra Muir Eckert, Michael S. Kay
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Publication number: 20170189405Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.Type: ApplicationFiled: May 27, 2015Publication date: July 6, 2017Applicants: Navigen, Inc., The University of Utah Research FoundationInventors: Kirill Ostanin, Mark Shenderovich, Ashok Bajji, Christopher L. Cioffi, Neil Moss, Hariprasad Vankayalapati, Dean Li
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Patent number: 9092391Abstract: The present invention provides methods of determining a Genetic Composite Index score by assessing the association between an individual's genotype and at least one disease or condition. The assessment comprises comparing an individual's genomic profile with a database of medically relevant genetic variations that have been established to associate with at least one disease or condition.Type: GrantFiled: November 30, 2007Date of Patent: July 28, 2015Assignee: Navigenics, Inc.Inventors: Dietrich A. Stephan, Melissa Floren Filippone, Jennifer Wessel, Michele Cargill, Eran Halperin
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Publication number: 20140172444Abstract: The present disclosure provides methods and systems for personal action plans based on an individual's genomic profile. Methods include assessing the association between an individual's genotype and at least one disease or condition and providing rating systems for an individual's action plan. Incentives to motivate and encourage people to improve their health and well-being are also disclosed herein.Type: ApplicationFiled: December 13, 2013Publication date: June 19, 2014Applicant: Navigenics, Inc.Inventors: Stephen M. MOORE, Michael A. NIERENBERG, Sean E. GEORGE, Laurie A. GOMER
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Publication number: 20100070455Abstract: The present disclosure provides methods and systems for incorporating multiple environmental and genetic risk factors into an individual's genomic profile. Methods include assessing the association between an individual's genotype and at least one disease or condition by incorporating multiple genetic risk factors, environmental risk factors, or a combination of both.Type: ApplicationFiled: September 11, 2009Publication date: March 18, 2010Applicant: Navigenics, Inc.Inventors: Eran Halperin, Jennifer Wessel, Michele Cargill, Dietrich A. Stephan
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Publication number: 20100042438Abstract: The present disclosure provides methods and systems for personal action plans based on an individual's genomic profile. Methods include assessing the association between an individual's genotype and at least one disease or condition and providing rating systems for an individual's action plan. Incentives to motivate and encourage people to improve their health and well-being are also disclosed herein.Type: ApplicationFiled: August 7, 2009Publication date: February 18, 2010Applicant: Navigenics, Inc.Inventors: Stephen M. Moore, Michael A. Nierenberg, Sean E. George, Laurie A. Gomer
