Abstract: The invention relates to a curable coating composition comprising at least one surface modifying amphiphilic additive and at least one amphiphilic siloxane-polyurethane coating composition. The invention also relates to methods of making and using the curable coating composition of the invention. The invention also relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the use of the curable coating composition of the invention.

Abstract: An aerogel hybrid and a method for preparing the aerogel hybrid. The aerogel hybrid includes a resin composition and a plurality of aerogel particles. The resin composition may fill the interstitial space between the plurality of aerogel particles. The aerogel hybrid may be produced by preparing the aerogel and preparing the resin composition, blending the aerogel and the resin composition together to form an aerogel hybrid and curing the aerogel hybrid for providing an aerogel hybrid containing resin mixture with the ability to fit large amounts of aerogel into the resin to enhance the aerogel's physical properties.

Abstract: The invention relates to a curable amphiphilic siloxane polyurethane coating composition. The invention also relates to methods of making and using the curable amphiphilic siloxane polyurethane coating composition of the invention. The invention also relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the use of the curable amphiphilic siloxane polyurethane coating composition of the invention.

Abstract: The present invention relates to a device for a scalable biomanufacturing platform for the production of modified cells such as CAR-modified T-cells while eliminating on-target/off-tumor toxicity and decreasing the current production cost by 500 times (per treatment), and to attendant methods. The includes a first chamber for proliferating a population of cells and a second chamber for modifying the cells to express a desired T-cell receptor antigen.

Abstract: Provided are methods for identifying tumor-derived extracellular vesicles. The methods can include combining an antibody and a sample under conditions suitable for formation of antigen-antibody complexes with tumor-derived extracellular vesicles. The methods also include exposing the tumor-derived extracellular vesicles to a compound that binds beta-sheet structures, and determining if there is a change in binding of the compound to the extracellular vesicles compared to one or more controls.

Abstract: The invention relates to a curable amphiphilic siloxane polyurethane coating composition. The invention also relates to methods of making and using the curable amphiphilic siloxane polyurethane coating composition of the invention. The invention also relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the use of the curable amphiphilic siloxane polyurethane coating composition of the invention.

Abstract: Defensible AI systems and methods may provide technical solutions for technical problems facing typical AI systems. An expert system may be used to address problems facing AI that systems operate without providing visibility into their internal decision-making processes. The expert system may be developed with meaning-assigned fact nodes. A gradient descent style training process may be used to improve the performance of expert system networks. In an example, a gradient descent training process identifies the contributions of rules and fact values to the outcome fact values, then distributes a portion (e.g., velocity value determined portion) of the error to each rule input weighting based on its proportion of overall contribution. These expert systems may use various approaches to training, such as various selected inputs used to calculate the difference value (e.g., error value), various network designs, various error and augmentation levels, and various different training levels.

Abstract: Provided herein is a method for producing an inactivated virus including a) heating the virus to a temperature sufficient to disrupt the virus membrane; b) exposing the virus of step (a) to a nucleic acid degrading enzyme; and c) cooling the virus to a temperature sufficient to reestablish the integrity of the virus membrane. Also provided herein is a vaccine produced using the instant method.

Abstract: A particle that includes a core and one or more layers. The core includes a fertilizer element. The one or more layers may include a polycation polymer and/or a polyanion polymer. Compositions include a plurality of particles and methods of using the particles and compositions containing the same.

Abstract: The invention relates to acetoacetylated lignin resin compositions comprising the reaction product of lignin and an acetoacetate ester. The invention also relates to (meth)acrylated lignin resin compositions comprising the reaction product of lignin and a (meth)acrylic compound. The invention also relates to methods of making the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to curable coating compositions comprising the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to methods of making the curable coating compositions of the invention. The invention also relates to methods of applying curable coating compositions of the invention to substrates. The invention also relates to articles of manufacture comprising a curable coating composition of the invention and a method of making such article.

Abstract: The invention relates to novel hydrazide-based templates, methods of making the same, and methods of using the hydrazide-based templates as molecular scaffolds for asymmetric light driven transformations, light driven material synthesis, and biological applications. Furthermore, the present invention relates to photoinitiators, monomers, and polymers derived from biomass, together with methods and methods of using the same.

Abstract: The invention relates to a curable coating composition comprising a nanoparticle-polymer composition and, optionally, superamphiphobic nanoparticles. The nanoparticle-polymer composition comprises the reaction product of an epoxy resin, a hydroxy-terminated poly(dimethylsiloxane), and a silane coupling agent, and a hybrid nanofiller. The superamphiphobic nanoparticles comprises the reaction product of silicon dioxide nanoparticles and 1H,1H,2H,2H-perfluorodecyltrichlorosilane and/or 1H,1H,2H,2H-perfluorododecyltrichlorosilane (FDDTS). The invention further relates to a cured coating composition of the invention, objects coated with the curable coating composition of the invention, methods for making the curable coating composition of the invention, and the use of the curable coating composition of the invention to coat substrates.

Abstract: Suspending fibers within a substantially similar direction within flow field allows for an even dispersion of fibers in a manufactured composite. The flow field can be established within a resin tank so as to control orientation of the fibers. An advantage of this approach is that fiber orientation can be changed layer by layer during printing. No matter where the reinforcements need to be, the fibers can be aligned on the fly to accommodate. 3D prints can made stronger for a very wide range of objects and opportunities.

Abstract: The presently disclosed invention relates to products and methods of treating cancer in a patient comprising administering to the patient a pharmaceutically therapeutic dose of a chemotherapeutic, or any pharmaceutically acceptable salt, solvate, or prodrug thereof, conjugated to a nanocarrier. According to a further embodiment, the chemotherapeutic has a primary (1°) amine (—NH2) group in within a pharmaceutical structure of the chemotherapeutic structure. According to a further embodiment, the chemotherapeutic is one of a platinum-based pharmaceutical and an Anthracycline family pharmaceutical. According to a further embodiment, the chemotherapeutic is one of gemcitabine, methotrexate, cisplatin, oxaliplatin, doxorubicin, daunorubicine, idarubicine, and epirubicine. According to a further embodiment, the chemotherapeutic is either attached to the nanocarrier by means that includes covalent bonds or is attached by means that does not included covalent bonds.

Abstract: The invention relates to a curable coating composition comprising at least one surface-modifying amphiphilic additive and at least one siloxane-polyurethane coating composition. The invention also relates to methods of making and using the curable coating composition of the invention. The invention also relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the use of the curable coating composition of the invention.

Abstract: A power conversion circuit is used in a solar array suitable for, e.g., roadside adjacent installation. The power conversion circuit includes an inverter with a first stage electrically coupled to one or more solar panels. A third stage of the circuit has a DC to AC converter that provides less than a 50 VAC load voltage to a load, and a second stage that is coupled between the first and third stages and provides an isolated electrical power coupling therebetween. A sync interface communicatively couples a controller to other controllers dedicated to one or more other respective inverters of the solar array via a sync signal. The controllers synchronize the third stages of the inverters via the sync signal. The third stages of the inverters are coupled in series to provide a load output voltage.

Abstract: The invention is directed to curable polyurethane coating compositions which may be used to form fouling release coatings, e.g., for use in protecting boat hulls. A curable coating composition of the invention comprises a) at least one amphiphilic additive; b) at least one polyisocyanate; c) at least one polyol; and d) optionally, at least one amphiphilic PEG-PDMS isocyanate prepolymer. Another curable coating composition of the invention comprises the at least one polyisocyanate, b), the at least one polyol, c), and the at least one amphiphilic PEG-PDMS isocyanate prepolymer, d). The invention further relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the steps of coating the surface with the curable coating compositions of the invention to form a coated surface, and curing the coating composition on the coated surface.

Abstract: The invention relates to a curable coating composition comprising at least one glycidyl carbamate (GC) resin, at least one amphiphilic GC-functional prepolymer, and at least one curing agent. The invention also relates to a method of making the curable coating compositions. The invention also relates to an article of manufacture comprising the curable coating composition of the invention and a method of making such article. The invention also relates to a fouling-release (FR) coating system and an anti-coating system, each of which comprises the curable coating compositions of the invention, methods of applying the FR coating systems and anti-coating systems to substrates, and methods for reducing or preventing biofouling or icing of a surface exposed to an aqueous environment using the FR coating systems.

Abstract: The grape plant cultivar ‘ND054.27’ is a white wine grape which exhibits excellent yield and superior cold hardiness and disease resistance.

Abstract: The grape plant cultivar ‘ND213’ is a red wine grape for white wine production which exhibits superior cold hardiness and disease resistance.